@FadenLab

Translational Head and Neck Cancer Genomics | Mass Eye and Ear | Harvard Medical School

 Boston, MA
faden-lab.mgh.harvard.edu
Joined September 2021
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New in @CCR_AACR : we can read the physical state of the HPV genome from a tube of blood — and it's prognostic of recurrence and survival across HPV+ cancers. 🧵
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Co-first authors @adamsfisch, Samuli Eldfors, Annie Abruzzo, with the team across @MGBResearchNews @broadinstitute. Funded by @NIDCR_NIH.
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Read more here: aacrjournals.org/clincancerr…

Whole-Genome HPV Liquid Biopsy for HPV-Associated Cancer Detection and Viral Physical State...

AbstractPurpose:. Human papillomavirus (HPV)–associated carcinomas (HPV+ cancers) account for 5% of all cancers. Circulating tumor HPV DNA (ctHPVDNA) assays for HPV+ cancer surveillance have limited...

aacrjournals.org
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Faden Lab retweeted
AHNS@AHNSinfoJul 18
World leaders discuss the future of cancer diagnostics and monitoring at the First Annual Liquid Biopsy Summit organized by Dr Daniel Faden #AHNS #AHNS2026
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Congrats Michael!
New College, Oxford@NewCollegeOxJul 8
DPhil student Michael Bryan has been awarded the prestigious British Neuro-Oncology Society (BNOS) Young investigator Award, for his work on using AI and computational biology to design better personalised cancer vaccines for people with glioblastoma Find out more on our website
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Great trip to Kyoto for the AACR-JCA meeting. Wonderful to see old friends and make new ones. Thank you to @AACR and outgoing AACR president @lillian_siu for the invitation to speak on our work advancing liquid biopsy - and the late night yakitori, chicken hearts, liver and all.
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Ultrasensitive HPV DNA Blood Test Could Help Personalize Head and Neck Cancer Treatment HPVDeepSeek, a whole genome test for HPV DNA, predicts recurrence and survival in people with #headandneckcancer @FadenLab @MassGenBrigham #IPMoncology #HPV #WGS hubs.li/Q04lgywh0

Ultrasensitive HPV DNA Blood Test Could Help Personalize Head and Neck Cancer Treatment

HPVDeepSeek, a whole genome test for HPV DNA, predicts recurrence and survival in people with head and neck cancer.

insideprecisionmedicine.com
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A whole genome sequencing assay named HPV-DeepSeek sniffs out signs of residual disease after surgery in patients with #HPV+ head and neck cancer, and detects recurrence earlier than digital PCR and standard clinical criteria. @FadenLab @BIDharvardOHNS scim.ag/3S52VLF
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Big day for our lab! New paper using our HPV-DeepSeek assay, an ultrasensitive HPV WGS-based liquid biopsy for MRD detection in HPV+ head & neck cancer, is out today in @ScienceTM 🧵 🔗 science.org/doi/10.1126/scit…

Clinical validation of an HPV whole-genome sequencing assay for MRD detection in patients with HPV+...

An ultrasensitive blood test accurately detects residual disease after surgery and predicts recurrence and survival in HPV+ head and neck cancer.

science.org
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Huge thanks to our co-first authors Shun Hirayama, Yana Al-Inaya, @Michael_E_Bryan, @dipondas30 and @alanyelg. And to our clinical and scientific teams @MassEyeAndEar, @MassGeneralNews, Broad Institute, Broad Clincal Labs. This is what collaborative science looks like
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Thank you to Andrea Anderson at @GenomeWeb and Laura Cowen at @InsidePrecisionMed amongst others for the thoughtful coverage: 📰 genomeweb.com/cancer/hpv-seq… 📰insideprecisionmedicine.com/…

HPV Sequencing Liquid Biopsy Test Detects MRD Early in Head and Neck Cancer Patients

Blood-based HPV whole-genome sequencing could help identify recurrence in HPV-positive patients and guide adjuvant therapy.

genomeweb.com
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