Florian Praetorius

While most of the work focuses on artificial systems, Adam also shows that the approach can be used to add an "off-switch" to a previously designed minibinder (Neo2) that binds to the IL-2 receptor. Adams design binds the receptor tightly, but can be removed by adding competitor

Adam combined computational protein design with some smart concepts to generate a system in which the competition occurs via a conformational change.

this one?

(...) (e.g. tetramer without peptide, trimer with peptide). Unfortunately @Reubensbrews and @RavennaBrewing no longer make #CrispyShifty , the beer that retroactively inspired the entire series of projects, so we can't show good pictures of the larger assemblies...

Only downer is that @Reubensbrews and @RavennaBrewing are no longer making #crispyshifty, the beer that retroactively inspired us to design proteins that have two fully structured states (=crispy) and readily switch between those states (=shifty).

Shoutout to @RavennaBrewing and @Reubensbrews who with their collaborative beer #CrispyShifty unknowingly and retroactively inspired us to design proteins that are both crispy (fully structured and well defined in both states) and shifty (readily switching between both states)