Acacia Dishman, MD PhD retweeted
Replying to @FloPraetorius @proleu
Once again, thanks to Maxx and @StollPatro, @adam_broerman, Cullen, @ArvindSPillai1, Abbas, @cacidish and @bvolkie, @DaveJuergens, @JustasDauparas, the IPD cores, and everyone at @UWproteindesign!
Go team #crispyshifty
Acacia Dishman, MD PhD retweeted
Replying to @proleu
@proleu and I are excited to see our work on multistate design of hinge proteins finally published as a peer-reviewed paper
science.org/doi/full/10.1126…
Acacia Dishman, MD PhD retweeted
In the August issue, read Reviews on:
#metamorphic protein folding (@cacidish)
activating and silencing #enhancers
#tudordomain interactions (@NeugebauerKarla)
#phosphoproteinphosphatases (@KettenbachLab)
and #adhesionGPRCs
cell.com/biochemical-science…
Acacia Dishman, MD PhD retweeted
📢 Online now - the Review "#Metamorphicprotein folding as evolutionary adaptation" from @cacidish and Brian Volkman
@MedicalCollege.
#foldswitching #ancestralsequencereconstruction #conformationaldynamics #proteinfitness
Read it here 👉 authors.elsevier.com/a/1hAp-…
Acacia Dishman, MD PhD retweeted
Replying to @HarvardRadOnc
@_AkshatPatel_ @abrarc @JzStack @palakp97 @cacidish
🎉 Congratulations! Can't wait to welcome you in person!
Acacia Dishman, MD PhD retweeted
We are SO excited to announce the results of the 2023 Match and to introduce you to our HROP class of 2028!! #Match2023 #MatchDay #radonc #MedTwitter
Acacia Dishman, MD PhD retweeted
Shoutout to @RavennaBrewing and @Reubensbrews who with their collaborative beer #CrispyShifty unknowingly and retroactively inspired us to design proteins that are both crispy (fully structured and well defined in both states) and shifty (readily switching between both states)
Acacia Dishman, MD PhD retweeted
Replying to @proleu
@proleu and I proudly present our preprint on designed hinge proteins that switch between two fully structured conformations:
biorxiv.org/content/10.1101/…
Acacia Dishman, MD PhD retweeted
It really was a team effort! Thanks to Maxx and @StollPatrol, @adam_broerman, Cullen, @ArvindSPillai1, Abbas, @cacidish and @bvolkie, @DaveJuergens,@JustasDauparas, the IPD cores, and everyone at @UWproteindesign!
Go team #CrispyShifty!
Acacia Dishman, MD PhD retweeted
We are mourning the loss of Dan Tawfik, a brilliant researcher and longtime friend of the institute. His scientific accomplishments will endure, as will his kindness, generosity, and humor. Dan made the world a better place.
Acacia Dishman, MD PhD retweeted
The primary @ScienceMagazine article is titled "Evolution of fold switching in a metamorphic protein" by @cacidish in the lab of Brian Volkman and their colleagues: science.sciencemag.org/conte…
Acacia Dishman, MD PhD retweeted
my latest for Quanta - a story about metamorphic proteins that switch rapidly and reversibly between two folds. A superpower for cells. But basically double trouble for protein designers 😅.
@cacidish @UWproteindesign @MedicalCollege
Proteins are molecular origami at its finest. A recent study shows that, while most proteins have a single stable shape and function, some have evolved to quickly refold themselves for different functions as needed. quantamagazine.org/metamorph…
So excited to share our work on the evolution of metamorphic proteins!
science.sciencemag.org/conte…
Acacia Dishman, MD PhD retweeted
A shapeshifting immune system protein called XCL1 evolved from a single-shape ancestor hundreds of millions of years ago. Now, researchers at MCW discovered the molecular basis for how this happened. Learn more: mcw.edu/newsroom/news-articl…














