Pedro Galante's Lab: Gene expression regulation, mobile elements, cancer targets, and bioinformatics tools.
Sao Paulo, Brazil
Joined June 2020
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Super happy to share that our paper is finally published in Aging Cell! 🥳
Read the full manuscript here: onlinelibrary.wiley.com/doi/…
Our study investigated transcriptomic entropy using RNA-sequencing data from thousands of samples across human and mouse tissues.
Are pseudogenes just "genomic fossils"? Our latest preprint says no! By analyzing 244 high-quality vertebrate genomes from VGP, we show that processed pseudogenes (retrocopies) are actually dynamic substrates for evolutionary innovation. Full study here: biorxiv.org/content/10.64898…
In mammals, we found a flux of genes escaping the X chromosome to autosomes via retroduplication. These copies are enriched for protein-coding potential and are kept under purifying selection—strong evidence that meiotic sex chromosome inactivation drives this genomic reshuffling
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This work was made possible by the incredible efforts of the Vertebrate Genomes Project (VGP) consortium. Huge thanks to all collaborators, sequencing centers, and field teams for providing the high-quality, chromosome-scale assemblies that powered this study! #OpenScience #VGP
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Excited to share high-quality genomes for sloths and anteaters and some amazing mammalian biology findings! 🦥🧬 link.springer.com/article/10…
Very proud of this work, we’re now investigating the impact of active L1s in sloths and the functions of these domesticated retrocopies. Huge thanks to all collaborators who contributed to this project, and to the excellent opportunity for our lab to participate in this research.
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Finally, it's super cool that our paper was picked up by non-scientific media, both nationally and internationally!
oglobo.globo.com/saude/notic…
bbc.co.uk/newsround/articles…
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I'm pleased to share our recent review in Molecular Cancer Research, which examines the relationship between L1 activation and endocrine-related cancers. Many thanks to Rafael Loch's group for the excellent collaboration.
Now online: LINE-1 Activation in Endocrine-Related Cancers: Molecular Mechanisms and Translational Implications doi.org/10.1158/1541-7786.MC…
We are excited to share our latest paper, where we review the role of endogenous retroviruses in our genomes.
Read the full story of "Endogenous retroviruses in aging and cancer: from genomic defense to oncogenic activation" here: link.springer.com/article/10…
Therapeutic potential unlocked: HERV reactivation (via DNMT inhibitors) can induce “viral mimicry,” boosting antitumor immunity & enhancing immunotherapy. They’re not just genomic fossils—they’re emerging biomarkers and immunotherapeutic tools. #Immunotherapy #PrecisionOncology
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