Androgens lower hepcidin. Hepcidin is the body's master iron regulator, it binds it and prevents it from entering the bloodstream
If you have LOW iron markers on TRT, you have something very odd going on as that's the opposite signal from what should be happening
Both claims can be true.
Ben is claiming that an early response to fasting is elevated GH, to shift substrate utilization towards liberated free fatty acids
You are claiming that extended fasting catabolizes muscle tissue
Neither of you are wrong
How's your pregnenolone experience been?
I added it about a week ago but can't say I've noticed anything yet.
There was a study showing oral absorption was poor and that doses of 300-500mg were required to elevate levels, been taking 400mg (200mg x 2) myself
pmc.ncbi.nlm.nih.gov/articleā¦
Gavin Ray retweeted
I built bbtree, the foundation of databases and filesystems, and the fastest concurrent btree.
Code: github.com/XiangpengHao/bbtrā¦
Blog post & demo: bbtree.xiangpeng.systems/
Thorough evidence of the contrary compiled in:
"Pleiotropic effects of GLP-1 receptor agonists ā a narrative review of extra-metabolic outcomes in adults"
journals.viamedica.pl/medicaā¦
Reminds me of the guy who went to the Olympia and asked to check random bodybuilders' blood pressures:
youtube.com/watch?v=dFEid2ZRā¦
One of them almost had her beat: 187/118
> a blood pressure of 200/100 and a blood sugar of 500
Wow, she was really gunning for a high score, huh?
Besides: are you truly living if you're not walking around in a hypertensive crisis? š¤”
I just experienced something novel with LLM's I've never seen before:
For a single word, Gemini Argon 4 invented a term by combining a different language root with an English suffix:
> "Š±Š°Š½Š°l", from common Slavic "Š±Š°Š½Š°"-root with a Latin "l" suffix, for "banal"
> What worked? I don't have a freaking clue. If it comes back I'll be more scientific for sure.
Hey, props for being honest at least.
Awesome that you feel better.
So then how are you intending to discriminate whether any increase in muscle size is due to this drug or would have occurred regardless?
This has some interesting literature behind it
Seems to be one of the few compounds that causes local effects:
"MID-35 acts locally within the injected muscle compartment rather than clearing through systemic circulation"
For science, will you do only one side of body?
> "... blood work panels at every 12 weeks, continuous blood donation, blood glucose readings every day, blood pressure readings EOD, health supplement protocols we donāt skimp on"
If you don't have these RX'es are you truly BB'ing?
I usually skip the gym when sleep-deprived too
But there is good news: @BradSchoenfeld recently looked at the impact of sleep deprivation on muscle
It turns out you can still make solid gains if you feel like lifting that day
xitter.cf/BradSchoenfeld/status/ā¦
Does sleep really matter for muscle growth?
Our new critical review, just pubbed-ahead-of-print in SCJ, takes a deep dive into the evidence linking sleep and muscle hypertrophy.
Hereās what we found:
Severe sleep deprivation can reduce muscle protein synthesis and negatively affect hormones, strength, and training performance. Moreover, observational research links both short and excessively long sleep with poorer muscle health and greater sarcopenia risk.
But hereās the catch: there is surprisingly little direct evidence that habitual sleep duration actually affects resistance training-induced muscle growth. In fact, one of the few longitudinal studies found that sleeping ~1ā2 hours less per night did not impair hypertrophy or strength gains over 5 weeks of resistance training in untrained men.
So, while adequate sleep almost certainly plays an important role in supporting recovery and training quality, we currently cannot prescribe a specific amount as āoptimalā for maximizing hypertrophy. A reasonable starting point appears to be ~7ā9 hours per night. However, individual sleep needs likely vary considerably based on the interplay between genetic predispositions and lifestyle factors.
Bottom line: The mechanisms suggest sleep matters, but we still need long-term controlled studiesāespecially in trained liftersāto determine how much it actually affects muscle growth.
ovid.com/jnls/nsca-scj/fulltā¦
