Nwiss 🇸🇪🇪🇸🇺🇸🇬🇧🇪🇺 retweeted
Long-Term Effects of Myocardial Injury on 1-Year Outcomes in Hospital Survivors With COVID-19: A Prospective Cohort Study
🚨Myocardial injury in hospitalised COVID survivors → higher 1-year death & MACE. Angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers (ACEI/ARB) cut that risk, with 71 % still symptomatic(LongC0VID).
You only have ONE HEART and it remembers!
➡️Prospective cohort from Tongji Hospital (Wuhan) of 2,185 hospitalized COVID-19 survivors (Omicron era), of whom 531 had acute myocardial injury (elevated cardiac troponin),
➡️At 1-year follow-up, myocardial injury was independently associated with higher all-cause mortality and major adverse cardiovascular events (MACE) after multivariable Cox regression and propensity-score matching,
➡️Kaplan–Meier curves show the highest event rates in the myocardial-injury group not receiving ACEI/ARB,
➡️Long-term ACEI/ARB use was linked to significantly lower mortality (aHR ~0.44) and MACE in this subgroup,
➡️At one year, 71.5 % of survivors still reported persistent symptoms (LongC0VID, mainly fatigue and sleep disturbance), those with prior myocardial injury had worse quality of life.
➡️Whether prior vaccination attenuated the risk of myocardial injury itself, or whether reinfection modified 1-year outcomes, is not addressed in this study
➡️This is the first large Omicron-era Chinese prospective dataset that combines hard clinical endpoints, patient-reported outcomes, and an analysis of ACEI/ARB benefit specifically in the myocardial-injury subgroup.
‼️So, myocardial injury during acute Omicron hospitalization is not a transient lab abnormality, it marks a high-risk group that continues to die and suffer cardiovascular events and poorer quality of life a full year later, yet a simple, already-available drug class (ACEI/ARB) appears to blunt that excess risk.
‼️For clinicians and patients, the practical message is straightforward: anyone who had elevated troponin while hospitalised with COVID (even in the Omicron period) should be flagged for closer cardiac follow-up. The finding that continued ACEI/ARB use is associated with lower mortality and MACE supplies an immediately actionable, low-cost intervention for this subgroup. Persistent fatigue and sleep problems(LongC0VID) in nearly three-quarters of survivors also underscore that post-hospital recovery remains incomplete for many, reinforcing the need for structured post-COVID follow-up and clinics rather than a simple discharge! YOU ONLY HAVE ONE HEART!
#AvoidSars2 #AvoidReinfections
onlinelibrary.wiley.com/doi/…
Nwiss 🇸🇪🇪🇸🇺🇸🇬🇧🇪🇺 retweeted
1/
The Swedish public health establishment is currently giving an "honorary award" for "scientific integrity" to Dr. Jonas F. Ludvigsson. Let's pull back the curtain and look at what Swedish scientific integrity actually looks like behind closed doors. 🧵👇
ALT Hej, Jag vill lovorda ert initiativ som lyfter fram vikten av vetenskaplig integritet och akademisk frihet, men samtidigt vill jag uttrycka en viss förvåning över att Jonas F. Ludvigsson tilldelats hedersutmärkelsen för just dessa egenskaper. Bakgrunden är hans uppmärksammade publikation om öppna skolor i Sverige under det inledande skedet av covid-19-pandemin. Genom offentliggjord korrespondens med Anders Tegnell framgår att han observerade att dödligheten bland skolbarn i åldern 7-16 år under pandemins första månader var cirka 68 % högre än under jämförelseperioden, I stället för att redovisa detta resultat separat valde han att slå samman skolbarn med förskolebarn (1-6 år), vilket medförde att ökningen i den äldre gruppen inte längre framträdde på samma sätt. Jag undrar därför hur Forska! Sverige har resonerat kring följande frågor: 1. Anser ni att det är förenligt med vetenskaplig integritet att slå samman åldersgrupper med olika utfall när resultatet av sammanslagningen blir a
ALT 19:48 * 100% Google Lens ++ svenska engelska Hello, I would like to commend your initiative that highlights the importance of scientific integrity and academic freedom, but at the same time I would like to express some surprise that Jonas F. Ludvigsson was awarded the honorary award for these very qualities. The background is his well-known publication on open schools in Sweden during the initial stage of the Covid-19 pandemic. Published correspondence with Anders Tegnell shows that he observed that the mortality rate among schoolchildren aged 7-16 years during the first months of the pandemic was approximately 68% higher than during the comparison period. Instead of reporting this result separately, he chose to combine schoolchildren with preschool children (1-6 years), which meant that the increase in the older group no longer appeared in the same way. I therefore wonder how Forska! Sweden has reasoned on the following questions: 1. Do you consider it compatible with scient
Nwiss 🇸🇪🇪🇸🇺🇸🇬🇧🇪🇺 retweeted
For decades, people with ME/CFS struggled for recognition while researchers struggled for funding.
Then came Covid.
My latest for @business on how Long Covid is transforming the science of infection-associated chronic illness.
🎁🔗👇
bloomberg.com/news/articles/…
Nwiss 🇸🇪🇪🇸🇺🇸🇬🇧🇪🇺 retweeted
‼️ The same rules apply in outpatient setting and chronic illness management. 🩺
✔️ Believe the patient! (Yes, they really DO have 30 symptoms. Yes, they really DO have fatigue that severe. Yes, they really DO have brain fog that impairs work/school.)
✔️ You may not understand what's going on with your patient as a physician and a fellow human, but you should avoid judging your patient as "crazy," "anxious," "not right in the head."
✔️ Practice compassion and hopeful-realistic attitude. You should avoid making promises for a cure, but also avoid hopeless statements like, "There is nothing we can do for you," OR "Only a good psychiatrist/psychologist can cure you."
"Acts of compassion during a period of trauma may last a lifetime in a person’s memory."
Brian Kulp describes the lasting effects of compassion and humour from healthcare professionals during a medical emergency
bmj.com/content/395/bmj-2026…
Nwiss 🇸🇪🇪🇸🇺🇸🇬🇧🇪🇺 retweeted
Herpesviruses. The ones that lie dormant in us for life - wake up during COVID. Documented over and over. A new review maps it across the whole family and leaves the big question open - is the reawakening driving the illness, or just a sign of how battered the immune system is?🧵
Nwiss 🇸🇪🇪🇸🇺🇸🇬🇧🇪🇺 retweeted
COVID does that.
2 of my doctors in their 40s have had strokes shortly after COVID infections. They're both practicing, but have different ways of dealing with the reality of a dangerous virus: One became a denier, and the other treats Long Covid.
News that U.S. Sen. Chris Murphy suffered a stroke was jolting in part because of his age: 53.
Stroke rates are generally higher among older adults, but the data shows they’ve been rising among people younger than 55. (via @PolitiFact) to.pbs.org/3UDyq0M
Nwiss 🇸🇪🇪🇸🇺🇸🇬🇧🇪🇺 retweeted
2/ PolyBio is actively supporting this project using 7-Tesla fMRI in patients with infection-associated chronic disease (e.g. LongCovid and ME/CFS) to determine evidence of structural abnormalities in the dorsal brainstem and craniocervical junction; as well as cerebrospinal fluid flow problems, brain blood flow issues, intracranial pressure changes, and dysregulation of vagus nerve signaling.
polybio.org/projects/case-st…
Nwiss 🇸🇪🇪🇸🇺🇸🇬🇧🇪🇺 retweeted
Hi everyone, we’ve been working on something 🙏🏼 I’ve written a second letter to Andy Burnham, alongside 360 sports people, to urge him to meet with me and fund research into my much neglected health issue which impacts millions of others.
I can’t believe 360 people signed in just 1 week, so many amazing names and messages still coming in of people wanting to add theirs (so feel free to message to add yours, we’re keeping on the pressure!!!)
The list includes 114 Olympians, with 77 medals between them (and that’s not even including Worlds and Europeans 🤯). Also some huge names from football and many other sports!!
Thank you SO much to everyone that signed, I can’t tell you how much it means to me when I’m truly at rock bottom ❤️❤️❤️
I know everyone wants their issues taken seriously, but this has been neglected like nothing else. WE HAVE 0 APPROVED TREATMENTS!!! Please listen 🙏🏼 @andyburnham @number10gov @UKLabour @DHSCgovuk
Nwiss 🇸🇪🇪🇸🇺🇸🇬🇧🇪🇺 retweeted
Stanford researchers studied 27 autoimmune patients and found CD19 CAR T-cell therapy cleared EBV-infected, autoreactive B cells that resisted rituximab.
8 of 12 CAR T-cell patients achieved sustained drug-free remission.
biorxiv.org/content/10.64898…
Nwiss 🇸🇪🇪🇸🇺🇸🇬🇧🇪🇺 retweeted
Finally, a Molecular Signature That Tells ME/CFS Apart From “Just Being Tired”
danilobuonsenso.substack.com…
Nwiss 🇸🇪🇪🇸🇺🇸🇬🇧🇪🇺 retweeted
I'm feeling this Patrick Stewart quote today. I was born with genes that cause APS1, celiac, hemochromatosis, and CVID. The best made plans still fail when your body works against you.
My brother, who is an engineer, thinks if he plans properly, he will be fine. He blames my need for assistance on lack of planning and effort. Called me entitled. But I planned and saved, same as him, until my arm injury, autoimmunity, tick bites, and COVID infections one by one derailed my plans and exhausted my savings. Maybe his plans will work out and he will be fine, but perhaps they will not. There is no reason to expect a certain positive outcome- that's a truly entitled mindset. Life does not owe you anything due to your planning. It is vicious and random in who it rewards and ravages.
It was merely genetic chance that gave my brother and I dramatically different stories.
Nwiss 🇸🇪🇪🇸🇺🇸🇬🇧🇪🇺 retweeted
Professional cyclist Esmée Peperkamp, 29, says she can barely walk after developing severe Long COVID.
She also alleges years of inadequate medical care, hormonal dysfunction, and RED-S.
Her former team faces an investigation.
idlprocycling.com/cycling/es…
Nwiss 🇸🇪🇪🇸🇺🇸🇬🇧🇪🇺 retweeted
We're headed into a new phase with Soren - one that we have deferred until he was closer to full grown. The mix of neuro-inflammation, viral/immune insults to his connective tissue and his genetics have exacerbated his craniocervical instability (CCI). 🧵1/2 #longcovid #mecfs
Nwiss 🇸🇪🇪🇸🇺🇸🇬🇧🇪🇺 retweeted
The brain fog lived experience.
When someone with Long COVID says “I can read a page, but I can’t retain it,” I don't think “fatigue” captures it.
A 2026 study (24,095 people; 548 with ongoing Long COVID symptoms) found deficits in sustained attention.
Researchers found links between Long COVID symptoms and attention/memory difficulties beyond fatigue alone. Fatigue building during tasks mattered too.
In clinic, we need to ask about cognition—not just tiredness.
What does brain fog feel like for you?u?
PS. Observational modelling cannot prove a mechanism.
doi.org/10.1093/braincomms/f…
Nwiss 🇸🇪🇪🇸🇺🇸🇬🇧🇪🇺 retweeted
Short 🧵
Swedish research does not seem to have high standards for scientific integrity, given that Jonas F. Ludvigsson is receiving an award for precisely this. ->
forskasverige.se/jonas-f-lud…
Nwiss 🇸🇪🇪🇸🇺🇸🇬🇧🇪🇺 retweeted
Jools Oliver, 51, revealed she was diagnosed with ADHD and autism in her 40s after her children received similar diagnoses.
She describes decades of exhaustion and misunderstanding.
She also lived with Long COVID for two years.
standard.co.uk/showbiz/jamie…
Nwiss 🇸🇪🇪🇸🇺🇸🇬🇧🇪🇺 retweeted
If you don’t have hypermobile ehlers-danlos syndrome, is having your hair washed in the sink at the hair salon relaxing? Because for me it’s so painful and I feel like I’m trying to hold my neck up. They’re always like “relax” and I’m like I can’t… lol
Nwiss 🇸🇪🇪🇸🇺🇸🇬🇧🇪🇺 retweeted
Peer-reviewed now.
Human T cells did show up, did recognise the virus, and still didn't clear it. By week 8 the CD4 cells had dropped their naive identity and gone cytotoxic - TEMRA - with IFN/JAK-STAT only switching on late, nothing like it acutely. Mice without T cells mounted the stronger innate antiviral response. Neither group cleared the virus.
A failure to resolve.
Nwiss 🇸🇪🇪🇸🇺🇸🇬🇧🇪🇺 retweeted
People in the Long Covid and MECFS Community are now dying with regularity.
Pretty soon, Twitter will be full of the Ghost Accounts of those no longer with us.
It's an incredibly scary time to be in our community right now and we should all be taking care of each other.
Nwiss 🇸🇪🇪🇸🇺🇸🇬🇧🇪🇺 retweeted
University of Oviedo researchers studied 41 people and found that those with Long COVID recalled significantly less verbal information after 9 months, despite similar initial performance.
Memory retrieval was also slower.
sciencedirect.com/science/ar…