MD/PhD Candidate in @RobersonLabUAB • @UofAlabama '16 • Molecular simulations are just grant-funded computer games #compchem #doubledocs
Joined February 2020
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I promised my labmates I'd make a Twitter profile when my first research paper hit Pubmed, but apparently I was here already
Nice computational work on TREM2 showing non-local structural perturbations may be caused by AD-linked TREM2 variants!
Neurodegenerative Disease–Associated Variants in TREM2 Destabilize the Apical Ligand-Binding Region of the Immunoglobulin Domain frontiersin.org/article/10.3…
Hunter B Dean retweeted
Researchers, join your colleagues at the largest and most influential international global meeting dedicated to advancing dementia science. #AAIC20 is now a virtual event, free of charge. Register today: bit.ly/30vOVh4.
Hunter B Dean retweeted
Excited to share @RobersonLabUAB's preprint on AD risk gene BIN1 driving Tau-dependent network hyperexcitability. Thank you to @DayLabUAB and @LLMcMahonNeuro labs for an excellent collaboration!
Alzheimer's disease risk gene BIN1 induces Tau-dependent network hyperexcitability biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Me seeing similar studies getting published while I sit in isolation listening to Lofi Hip Hop Radio #doubledocs #phdchat
Hunter B Dean retweeted
Full length SARS-CoV-2 spike protein with glycans running in MD shows vastly altered accessibility for small molecules and antibodies (aka #glycotime for the #COVID19 #demogorgon) @LCasalino88 (movie) @zied_gaieb @abbydommer @AmaroLab
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Not knowing a rare disease incidence is a huge problem for patient groups and drug developers.
@LalDennis + colleagues just produced an exceptionally valuable resource: prediction of the incidence of 101 monogenic neurodevelopmental disorders
Pls 🔃
pubmed.ncbi.nlm.nih.gov/3216…
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"Everything we do before a pandemic will seem alarmist. Everything we do after a pandemic will seem inadequate."
Michael O. Leavitt, U.S. Secretary of Health and Human Services, 2007.
Hunter B Dean retweeted
Update. The Cleveland Clinic has developed a COVID 19 test that gives results in 8 hours as opposed to the 2-3 days it takes for the other tests.
They developed the test in NINE days, I repeat nine. Scientists worked 24/7 once the CDC gave them the okay on 3/2.
Scientists: Avoid touching your face to slow the spread of Coronavirus
Trump: Claims to have a “natural ability” for science
Scientists:
Hunter B Dean retweeted
Hilarious description how the USMLE's updated grading policies affect "the medical student stress curve." The 2020 UASOM Best Medicine Show youtube.com/watch?v=GVwdowi0…
Hunter B Dean retweeted
1/25 Part 1 - Why does soap work so well on the SARS-CoV-2, the coronavirus and indeed most viruses? Because it is a self-assembled nanoparticle in which the weakest link is the lipid (fatty) bilayer. A two part thread about soap, viruses and supramolecular chemistry #COVID19
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As a data scientist, am I the best statistician in my group?
Of course not.
But do I make damn sure the code I write is high quality?
No.
But do I work hard to understand the details of the application more deeply than anybody else on the team?
Also no.
Hunter B Dean retweeted
The Sewell-Loftin Lab website is up and running! And we are looking to hire graduate students. Please help spread the word to help find recruits who are interested in how biomechanics affect tumor growth.
sites.uab.edu/mk101969/
Another piece of the #Alzheimers puzzle is up on @biorxiv_neursci just in time to talk about at the @UABSOM Neurodegeneration Retreat tomorrow! Thanks to @tombrettlab for leading the way and for wanting to tag on a bit of #compchem!
Happy to share our latest pre-print, mapping the interaction between TREM2 and ApoE, and demonstrating sTREM2 can inhibit amyloid beta polymerization! Great work @dlkober . Enormous help from @RobersonLabUAB @HBDeanMSTP @JABLab3 !
biorxiv.org/content/10.1101/…
Hunter B Dean retweeted
Research in Nature reports structures of an orphan G protein-coupled receptor, one with no known endogenous ligand, that can activate itself. go.nature.com/39Uib2m
Hunter B Dean retweeted
Listening to parents of #raredisease; Yes you can help other patients! We just need to do a better job of helping you. #phenopackets #datasharing #RareDiseaseDay @ChildrensAL @UABSOM @cctsnetwork
@GA4GH Niemann-Pick needs more data: monarchinitiative.org/diseas…
Keynote speaker at UAB 'Informatics Application’ @ontowanka making a clear case for how patients with rare diseases benefit when genetic databases work to communicate with each other #rareDisease #openscience @cctsnetwork @ChildrensAL @UABSOM
Whoops, my inability to type shouldn’t prevent @ontowonka from getting full credit for an awesome talk