@HVoedts

Postdoctoral scientist in the Collet Lab @JFClab. @EMBO fellow. Bacterial cell envelope. Antibiotics. PhD from @ArthurM_Lab. 🧫🧬💊

 Bruxelles, Belgique
deduveinstitute.be/research-group/jean-francois-collet
Joined August 2020
  • Tweets58
  • Following203
  • Followers70
I am excited to present the latest work from my PhD @ArthurM_Lab @CRCordeliers published in @NatureMicrobiol thanks to the help of my brilliant co-author @canopele1. Here are the main findings: 1/7
Nature Microbiology@NatureMicrobiol4 Mar 2024
OUT NOW: New study by @HVoedts @canopele1 and Michel Arthur digging into the mechanisms of (p)ppGpp-dependent beta-lactam resistance in E. coli 🦠💊 nature.com/articles/s41564-0…
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And that’s a wrap on the Great Wall Symposium 2025! Roll on 2027, venue to be confirmed shortly …
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You thought all OMPs were trimeric? 🧐 Not in our predator B. bacteriovorus! 🦠 Excited to have contributed to this great collab with the Lovering lab on this intriguing protein. @lalouxlab.bsky.social nature.com/articles/s41467-0… #BacterialPredation #Bdellovibrio #StructuralBiology

A porin-like protein used by bacterial predators defines a wider lipid-trapping superfamily

Nature Communications - This study reveals that an outer membrane protein from the predator Bdellovibrio bacteriovorus forms a pentameric assembly that traps a lipid monolayer within. This allows...

nature.com
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Out Now! Cyclic-di-AMP modulates cellular turgor in response to defects in bacterial cell wall synthesis bit.ly/3FZ4jJY #CyclicDiAMP #BacterialCellWall #Microbiology
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Beta-lactams covalently bind to Penicillin Binding Proteins and have been the mainstay of antimicrobial chemotherapy for decades. In this new paper with colleagues @Bicycle_tx we show a new way to hit old targets: rdcu.be/eoaRI
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New preprint 🚨: with @Mariusz78897208 we found that the Bacteroidetes beta-barrel assembly machinery is quite different to E. coli. biorxiv.org/content/10.1101/… #cryoEM
Comparison of B. theta and E. coli BAM complexes. Only BamAD components are shared, and B. theta BAM has five novel components, BamF-J.

ALT Comparison of B. theta and E. coli BAM complexes. Only BamAD components are shared, and B. theta BAM has five novel components, BamF-J.

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Henri Voedts retweeted
GoemansLab@GoemansLab20 Jan 2025
Our lab is recruiting postdocs with strong expertise in molecular microbiology and/or phage biology to work on different antibiotics-related projects (more info epfl.ch/labs/upgoemans/). Please get in touch if interested (with CV and references)!

Goemans Lab of Drug-microbiota Interactions

UPGOEMANS

epfl.ch
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Henri Voedts retweeted
ASM
@ASMicrobiology8 Jan 2025
In #JBacteriology, researchers broadly discuss lipoprotein biosynthesis and trafficking, and ponder why the newest outer membrane (OM) assembly system (lipoprotein trafficking) has become so key to building the Proteobacterial OM. Read the review: asm.social/2f6
E. coli OM assembly pathways rely on OM lipoproteins. OM components assembled by each pathway are red. Lipoproteins of the Lpt, AsmA family, Mla, Bam, and Lol pathways are colored, all other proteins of biogenesis pathways are gray. In wild-type E. coli, LptE, BamD, and LolB are each individually essential. The Lpt system relies on LptE to assemble LptD and disaggregate LPS for insertion into the

ALT E. coli OM assembly pathways rely on OM lipoproteins. OM components assembled by each pathway are red. Lipoproteins of the Lpt, AsmA family, Mla, Bam, and Lol pathways are colored, all other proteins of biogenesis pathways are gray. In wild-type E. coli, LptE, BamD, and LolB are each individually essential. The Lpt system relies on LptE to assemble LptD and disaggregate LPS for insertion into the

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Happy to share our first preprint !! Identification of receptor-binding domains of Bacteroidales antibacterial pore-forming toxins biorxiv.org/content/10.1101/…

Identification of receptor-binding domains of Bacteroidales antibacterial pore-forming toxins

Bacteroidales are abundant Gram-negative bacteria present in the gut microbiota of most animals, including humans, where they carry out vital functions for host health. To thrive in this competitive...

biorxiv.org
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Henri Voedts retweeted
Foster Lab@foster_lab1 Nov 2024
We are very excited to announce our latest work on how MRSA conquers antibiotics. We show that high-level resistance to methicillin requires S. aureus to utilise an alternative mode of cell division to ensure its survival! @Sheffield_AFM @Olulana4 doi.org/10.1126/scienc…
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Watch how BAM and SurA fold proteins! Our cryoEM structures brought to life in this awesome animation by @phospho! Read about it in our paper published last month nature.com/articles/s41467-0… @RadfordLab @naranson
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Great conference in Marseille! ⛵ Many thanks to all the organizers and participants for this wonderful moment!
Cascales Lab@CascalesLab11 Oct 2024
Henri Voedts @HVoedts from @jf_collet’s lab on stage to present data on the role of the BepA metalloprotease in outer membrane biogenesis. #SecretionDays
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Thrilled to share that my PhD work is now on @biorxivpreprint! We show that bacterial growth in confined spaces generates large forces, to which bacteria adapt in a 3-step process. More info 👉biorxiv.org/content/10.1101/… Excited to present this work at #SFMCongress in 2 weeks!

Bacterial growth under confinement requires transcriptional adaptation to resist metabolite-induced...

Bacterial proliferation often occurs in confined spaces, during biofilm formation, within host cells, or in specific niches during infection, creating mechanical constraints. We investigated how...

biorxiv.org
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Calling all Bacterial Cell Wall enthusiasts look whats coming... September 2025 Sicily just sayin... thegreatwall-symposium.org/ (please RT)

The Greatwall-symposium

The Great Wall Symposium will take place from 18th to 20th September 2023 at the venue in The Vila Galé Sintra Hotel, in Portugal.

thegreatwall-symposium.org
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I am happy to share with you our last work on lipoprotein transport in Bacteroidetes! biorxiv.org/content/10.1101/…

LolA and LolB are conserved in Bacteroidetes and are crucial for gliding motility and Type IX...

In Gram-negative bacteria, lipoproteins are major components of the outer membrane (OM) where they play a variety of roles, from the involvement in membrane biogenesis to virulence. Bacteroidetes, a...

biorxiv.org
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Henri Voedts retweeted
CavaLab@CavaLab_MIMS12 Sep 2024
Our latest work is now out @NatureComms: Control of bacterial cell wall autolysins by peptidoglycan crosslinking mode nature.com/articles/s41467-0… Another great collaboration with the @DoerrLab @CavaLab_MIMS @mims_umea @umeauniversitet @KAWstiftelsen @scilifelab @Ucmr_sweden

Control of bacterial cell wall autolysins by peptidoglycan crosslinking mode

Nature Communications - The regulatory mechanisms governing peptidoglycan-degrading autolysins remain poorly understood. In this work, Alvarez et al. show that lytic transglycosylase activity is...

nature.com
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Henri Voedts retweeted
Lars Dietrich@laahrs11 Sep 2024
Point of View: Applied research won’t flourish without basic science doi.org/10.7554/eLife.102368

Point of View: Applied research won’t flourish without basic science

Three senior figures at the US National Institutes of Health explain why the agency remains committed to supporting basic science and research.

elifesciences.org
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[Job Alert] @LiselotDW Dewachter is hiring motivated candidate to develop her team. Position available: Lab technician cdn.sanity.io/files/b98ocrnx… More info on the research group: deduveinstitute.be/research-…
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Now out: An outer membrane porin-lipoprotein complex modulates elongasome movement to establish cell curvature in Rhodospirillum rubrum rdcu.be/dSHtx A great collaboration with @BramkampLab, Vollmer lab, Johann Heider, Timo Glatter, Eli Cohen and Volker Kleeberg. @SYNMIKRO, @Bio_UMR, @mpi_marburg
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Very excited to share our paper on outer membrane assembly which includes the first cryoEM structures of BAM-SurA complexes. A great team effort with @_JimHorne @J_A_Crossley @anton_calabrese @RadfordLab @naranson nature.com/articles/s41467-0…
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Henri Voedts retweeted
RadfordLab@RadfordLab2 Sep 2024
New paper from our team using smFRET MS and cryoEM to see SurA delivering OMPs to BAM. Well done all - proud to work with you all! rdcu.be/dSDfs.
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