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Harms Lab

@HarmsLabUAB

All things PD, MSA and neuroimmune🔬 This account is run by Ashley Harms and grad students.

 Birmingham, AL
neuroimmunology.wixsite.com/harmslab
Joined April 2023
  • Tweets39
  • Following139
  • Followers218
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Photo by Harms Lab (@HarmsLabUAB)
We’ve updated our BioRxiv preprint!🥳🧠Our study on co-pathologies and neuroinflammation now includes significant new findings that strengthen our conclusions! biorxiv.org/content/10.1101/…
Tau, amyloid-beta and alpha-synuclein co-pathologies synergistically enhance neuroinflammation and...

Tau, amyloid-beta and alpha-synuclein co-pathologies synergistically enhance neuroinflammation and...

Alzheimer’s and Parkinson disease pathology often co-occur, with amyloid-β and phosphorylated tau, found in 30-50% of idiopathic Parkinson disease cases. α-synuclein inclusions, a hallmark of...

biorxiv.org
Jhodi Webster, PhD (@neurojho) profile pictureJhodi Webster, PhD@neurojho14 Oct 2024
My first, first-author paper is finally out for preprint!! Here we show that co-pathologies are likely behind the neuroinflammation and neuropathology related to neurodegeneration. More to come!🤞🏾🫶🏾 biorxiv.org/content/10.1101/…
Amyloid-beta, alpha-synuclein and tau aggregated co-pathologies enhance neuropathology and neuroi...

Amyloid-beta, alpha-synuclein and tau aggregated co-pathologies enhance neuropathology and neuroi...

Lewy pathology due to alpha-synuclein (α-syn) inclusions is one of the major hallmarks of Parkinson’s Disease (PD). β-Amyloid (Aβ) and phosphorylated-tau, pathologies usually found in Alzheimer’s...

biorxiv.org
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COMING UP: Ashley S. Harms, Ph.D., will talk about "T Cells in Parkinson disease" as part of the @WorldPDCongress Research Spotlight 2025 series on June 3 at 10 a.m. CT! Learn more: buff.ly/FrtAmhL @UABHeersink
Image from UAB Department of Neurology (@uab_neurology)
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New WPC Blog Post T cells and Parkinson’s: What we know and where we are going by Ashley S. Harms, PhD @HarmsLabUAB Read here: worldpdcongress.org/home/202… WPC blog made possible with support from Supernus_Pharma @BlueRockTx & CND Life Sciences. #Parkinsons #Scicomm
T cells and Parkinson’s: What we know and where we are going — WPC Blog

T cells and Parkinson’s: What we know and where we are going — WPC Blog

by Ashley S. Harms, PhD

worldpdcongress.org
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New research from @HarmsLabUAB & colleagues finds that overexpression of #Parkinsons-associated lpha synuclein can drive microbiome dysbiosis in mice, limiting diversity with age nature.com/articles/s41598-0…
Image from The Science of Parkinson's (@ScienceofPD)
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A new review from @HarmsLabUAB & colleagues explores the emerging role of disease-associated microglia in #Parkinsons; "Investigating the spatiotemporal properties of DAM in PD could provide a strong baseline for comparison" across neurodegen. diseases frontiersin.org/journals/cel…
Image from The Science of Parkinson's (@ScienceofPD)
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Reminder: early bird registration is open for #MSA2025! 🔎 Don’t miss your chance to join the #global #MSA #community at this exciting hybrid event, happening 5/9-5/11, in #Boston or #virtually from anywhere in the world. #Register: missionmsa.org/international…
Image from Mission MSA (@MissionMSA)
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Abstract submissions are NOW OPEN for the T Cells in the Brain symposium TCB2025 tcellsbrain.org ! We are offering 10 travel awards to support national and international trainees ✈️ #neuroimmunology #tcells #Alzheimers #Parkinson’s # ALS #Epilepsy #MS

T Cells Brain 2027 - Phoenix

tcellsbrain.org

tcellsbrain.org
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Yesterday I successful defended my thesis! Thank you to everyone to helped me get to this point. @HarmsLabUAB thanks for being the best co-workers a girl could ask for. Looking forward to continuing my scientific journey with @lesleylezhang at Yale this Fall 😊
Image from Nicole J. Corbin-Stein (@njgallups)
Image from Nicole J. Corbin-Stein (@njgallups)
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Always happy to connect other Roadmap Scholars at the annual NEURAL conference. Thrilled to have the opportunity to share my research so far and so so honoured to have been chosen for the first place prize for oral talks! 🤞🏾🧠🥲 @UAB_NeuroRMS
Image from Jhodi Webster, PhD (@neurojho)
Image from Jhodi Webster, PhD (@neurojho)
Image from Jhodi Webster, PhD (@neurojho)
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Check out my newest PrePrint from @HarmsLabUAB ! Tissue resident memory CD8+ T cells are present but not critical for demyelination and neurodegeneration in a mouse model of multiple system atrophy biorxiv.org/content/10.1101/…

Tissue resident memory CD8+ T cells are present but not critical for demyelination and neurodegen...

Multiple system atrophy (MSA) is rare, fast progressing, and fatal synucleinopathy with alpha-synuclein (α-syn) inclusions located within oligodendroglia called glial cytoplasmic inclusions (GCI)....

biorxiv.org
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#YouBelong
Image from UAB Neuroscience Roadmap Scholars Program (@UAB_NeuroRMS)
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Harms Lab retweeted
Brain (@Brain1878) profile picture
Brain@Brain187814 Feb 2024
By comparing the brains of pts with mild motor deficits ± nigral synucleinopathy vs. sporadic PD, Chu et al. provide evidence that initiation of nigrostriatal DAergic degeneration occurs independently of a-syn aggregation and can be tau mediated. tinyurl.com/yn3aanun
Image from Brain (@Brain1878)
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Exciting news! My first first-author publication is out! 🤩 thank you to all the co-authors on the paper, especially @HarmsLabUAB for helping with this exciting discovery. actaneurocomms.biomedcentral…
IFNγ drives neuroinflammation, demyelination, and neurodegeneration in a mouse model of multiple...

IFNγ drives neuroinflammation, demyelination, and neurodegeneration in a mouse model of multiple...

Acta Neuropathologica Communications - Multiple system atrophy (MSA) is a rare and fatal synucleinopathy characterized by insoluble alpha-synuclein (α-syn) cytoplasmic inclusions located...

link.springer.com
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Harms Lab retweeted
Brain (@Brain1878) profile picture
Brain@Brain187827 Nov 2023
By comparing the brains of patients with mild motor deficits ± nigral synucleinopathy, and patients with PD, Chu et al. find that initiation of nigrostriatal DAergic neurodegeneration occurs independently of alpha-syn aggregation and can be tau mediated. tinyurl.com/mvmk6ej6
Image from Brain (@Brain1878)
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Harms Lab retweeted
UAB CNC (@UAB_CNC) profile picture
UAB CNC@UAB_CNC15 Sep 2023
Additional congratulations to trainee poster award winners @nbaumgar, @cardosorodrigo2 (not pictured), and @jhodi!
Image from UAB CNC (@UAB_CNC)
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IFNγ drives neuroinflammation and demyelination in a mouse model of multiple system atrophy biorxiv.org/content/10.1101/…
Image from John Lukens (@LukensJohnR)
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🔬Exciting research: Ashley Harms, Ph.D. & UAB team reveal border-associated macrophages drive neuroinflammation, impacting Parkinson's neurodegradation. #ParkinsonsResearch #uabneurology 💡🧠 @UABHeersink Click to read more: go.uab.edu/3Oqd6oB
Image from UAB Department of Neurology (@uab_neurology)
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Important new work on "border associated macrophages" (BAMS's) in Parkinson disease -emerging key regulators of brain inflammation, especially "DaBAMs" @UABHeersink @uab_neurology @NatureComms @ASAP_Research @MichaelJFoxOrg @NINDS @HarmsLabUAB uab.edu/news/research/item/1…
Image from David Standaert MD, PhD (@DavidStandaert)
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Had the best time representing #TeamKordower at the ASAP CRN meeting and didn’t do too badly snagging the Community Poster Award🙂🤞🏾 @ASAP_Research @HarmsLabUAB #CRNSanDiego2023
Image from Jhodi Webster, PhD (@neurojho)
Image from Jhodi Webster, PhD (@neurojho)
Image from Jhodi Webster, PhD (@neurojho)
Image from Jhodi Webster, PhD (@neurojho)
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Great review on Science about neuroimmunology. The year is 2023 and people are still saying the brain is isolated, protected, and has immune privilege 🙄.
Science Magazine (@ScienceMagazine) profile pictureScience Magazine
@ScienceMagazine22 Jul 2023
Our understanding of how the brain and immune system interact has changed substantially over the past years and decades. On #WorldBrainDay, check out a #ScienceReview on recent discoveries that are transforming our understanding of brain immunity: scim.ag/3rO
Image from Science Magazine (@ScienceMagazine)
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