@HirschiLab

Vascular Development Research || University of Virginia Tweets by lab members

hirschilabuva.com
Joined October 2022
  • Tweets32
  • Following201
  • Followers372
9Media
Hirschi Lab retweeted
PotenteLab@PotenteLab25 Apr 2024
I can’t wait to see @MTorrescnic, @makinenlab, @MarionaGraupera and @HirschiLab at this year’s Seeon meeting, where they will discuss concepts of cellular fitness, competition, and clonality in the cardiovascular system. For applications, visit: vwfb.de.
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Congratulations to Dr. Yen-Lin Chen from @sonkusarelab on his K99/R00 award for studying lymphatic endothelial Piezo1 and TRP channels in obesity! Many thanks to co-mentors and collaborators @ScallanLab, @HirschiLab, @conn_pann_fun @NIDDK @UVACVRC
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Excited to share our now-published work showing that obesity accelerates EndoMT in adipose tissue! @FrontCVMedicine. Using lineage-tracing mouse models, human cell culture assays, and human scRNAseq datasets, we show that obesogenic diet promote EndoMT. tinyurl.com/3bkffkdj
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Really amazing study here - outstanding work from @WesleyAbplanalp @StefanieDimmel1. I was able to help write a News & Views on this article as well: nature.com/articles/s44161-0… New technique that helped identify how small clone sizes in CHIP have large effects.
Stefanie Dimmeler@StefanieDimmel15 Sep 2023
Clonal hematopoiesis affects only a small number of cells in the blood. @WesleyAbplanalp now developed a method that demonstrates the specific effect in the mutated cells. Not only monocytes but also T-cells are affected! Learn more here: nature.com/articles/s44161-0… @NatureCVR
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Cool comparisons between different vascular beds and the endothelium within them. Thanks to @Luke_Dunaway and @melissa_luse for co-leading the way on this. – at Virginia, USA
Luke Dunaway@Luke_Dunaway24 Jun 2023
Our latest preprint is up! Check out mine and @melissa_luse work investigating endothelial heterogeneity in obesity using bulk seq, scRNA seq, and some beautiful en face imaging of arterial endothelial mitochondria! @conn_pann_fun biorxiv.org/content/10.1101/…

Loss of endothelial cell heterogeneity in arteries after obesogenic diet

Background It is well recognized that obesity leads to arterial endothelial dysfunction and cardiovascular disease. However, the progression to endothelial dysfunction is not clear. Endothelial cells...

biorxiv.org
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In our latest episode, we discuss a study from the lab of Dr. Karen Hirschi (@HirschiLab) at @Yale. Her lab identified miR-223 as a negative regulator of murine hemogenic endothelial cell specification and #myelopoiesis. 📒: bit.ly/3Jb450Q 🎧: bit.ly/3J6pckY
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A recent study by @HirschiLab identified microRNA-223 as a negative regulator of murine hemogenic #endothelial cell specification and endothelial-to-#hematopoietic transition. @UVACVRC @YaleGenetics 🖨️ Published in @Dev_Cell! bit.ly/3Jb450Q
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I was honored to chair the #regenerative_medicine session at @CURAMdevices summit 2023 with prof. Murphy. Including outstanding talks from prof. Hirschi @HirschiLab, prof. @johnglaffey, Dr. @MeadhbhBrennan, and Dr. @JohnJMulvihill 🍀
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Hirschi Lab retweeted
AHA Science
@AHAScience13 May 2023
Dr. karen Hirschi on “role of endothelial cell hyperproliferation and AVMs” 📌 Data showing control of endothelial cell proliferation prevents AVM formation. ⁉️ Can endothelial cell cycle inhibitors be used to treat AVMs? #VascularDiscovery23 @AHA_Research @CouncilPvd
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So incredibly proud of @CwiekAleksandra and her work. Presented today at #pas2023 Congratulations!!!
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A recent study by the @HirschiLab at @MedicineUVA shows that vascular #endothelial cell-expressed Cx43 regulates adult #NSC proliferation and differentiation. #neurogenesis More in @CellReports. 📚 bit.ly/41pby31
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Congratulations to the members of the BIMS 2020 cohort who have completed their quals/proposal defense and have advanced to CANDIDACY! 💙🧡 We were honored to have @DeanMKibbe join us and share her experiences at the bench and encouraging words for the time ahead. @MedicineUVA
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Throwback to #IVBM2022! Presenting my poster from the @HirschiLab @UVa_CellBio on the role of #Cx43 in the adult brain 🧠 #SVZ to @RuizdeAlmodovar!
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This study by @nickchavkin, @HirschiLab, and team shows that #venous #endothelial cells are enriched for the early G1 phase and BMP signaling, while #arterial endothelial cells are enriched for the late G1 phase and TGF-β signaling. 📌 @NatureComms 🖱️ go.nature.com/3g1yF18
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Hirschi Lab retweeted
IVBM2022@ivbm202214 Oct 2022
Starting in 20min #IVBM2022 Learn more about the translational Approaches in Vascular Biology and regeneration - join us in Junior Ballroom 3/4! Sponsored by @AppliedCVB
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