The Hughes Lab at UCI. Developing blood vessels-on-a-chip and vascularized micro-organ (VMO) technologies to study vascular biology, cancer, and rare diseases.
Joined July 2020
- Tweets101
- Following209
- Followers351
- Likes145
Hughes Lab - UCI retweeted
Any cardiovascular postdocs looking for a job? A tenure-track faculty position for cardiovascular research is open at LSU Health Shreveport. Excellent research infrastructure in a collaborative and supportive environment. Great place to start a lab.
lsuhsc.edu/shv/CareerOpportu…
Hughes Lab - UCI retweeted
Excited to share our organoid model of vascularized stem cell islets.
Great teamwork led by @KVyNguyenNgoc and Yesl Jun. Thanks to @someshtweet, @HughesLabUCI, @steven_c_george, @ChristmanLab, @Hugh_Bender, @KravetsVira, @HIRN_CC . 1/4
biorxiv.org/content/10.1101/…
Hughes Lab - UCI retweeted
Thrilled to have the opportunity to partner with @AracariBio @HughesLabUCI this week at #2022MPSWorldSummit to present a workshop to trainees discussing ways to allow physiology to inform development of micro physiological systems, and to demo the VMO platform!
Hughes Lab - UCI retweeted
We agree @BlumLabWisc ! It’s been fun to develop this together with @HughesLabUCI led by @Hugh_Bender .
Hughes Lab - UCI retweeted
Now LIVE in #NAVBO2021:
"Systems Biology & Modeling II" chaired by Drs. Sarah Parker & @bingmei_fu
Great schedule featuring talks from Drs. Shayn Peirce-Cottler, Yu Zhu, and Satomi Matsumoto @HughesLabUCI
Tune in now!
Hughes Lab - UCI retweeted
Amazing video from our collaborators @HughesLabUCI showing co-development of blood vessels and human micro-tumors!
This time-lapse video shows a human micro-tumour growing over 10 days in a lab. 🤯
The tumour, in blue, grows with the support of vessels, shown in red.
Dr Stephanie Hachey and Dr Christopher Hughes were awarded second place for their video. @NikonSmallWorld @HughesLabUCI
Hughes Lab - UCI retweeted
Chris and team - congrats! This is really awesome - how many years of toil for these precious seconds of exciting science!? Worth every long second!
Check out our 2nd place @NikonSmallWorld video. Images in our vascularized micro-tumor device, it shows microvessels (red) forming over time and growing micro tumors (cyan) as they respond to contact with those vessels.
Hughes Lab - UCI retweeted
This time-lapse video shows a human micro-tumour growing over 10 days in a lab. 🤯
The tumour, in blue, grows with the support of vessels, shown in red.
Dr Stephanie Hachey and Dr Christopher Hughes were awarded second place for their video. @NikonSmallWorld @HughesLabUCI
Hughes Lab - UCI retweeted
Vascularized Tumor-on-a-chip
A 12-unit microfluidic chip for colorectal tumor-fibroblast-EC coculture, mimicking in vivo heterogeneity & allowing precise drug test + stroma/vessel targeting, vs 2D/spheroid monoculture😎
@HughesLabUCI @LabonaChip 2021
pubs.rsc.org/en/content/arti…
Hughes Lab - UCI retweeted
Tumors in the body respond to drugs differently than those grown in a petri dish, but better #oncology models are hard to find. Co-founder Chris Hughes’ lab demonstrates why Aracari’s VMT™ better mimics human tumors to improve #drugdiscovery. tinyurl.com/4bpujcu2
Hughes Lab - UCI retweeted
Check out this work from CMCF affiliates and @HughesLabUCI on an in vitro tumor on a chip! Includes single cell transcriptomic analysis of the system. pubs.rsc.org/en/content/arti…
Hughes Lab - UCI retweeted
Tumors-on-a-chip are always fascinating! Congratulations to the team on getting to share your hard work with the world! 🌏
We are so excited to announce the publication of our latest paper in @LabonaChip: An in vitro vascularized micro-tumor model of human colorectal cancer recapitulates in vivo responses to standard-of-care therapy
pubs.rsc.org/en/content/arti…
Hughes Lab - UCI retweeted
At last! Our @NatRevDrugDisc article is published! This originally was a follow-up from our #TissueChip @KeystoneSymp meeting from over 2 years ago - although thankfully we could update it with all the cool new #OrganOnAChip work that's come out since then👍 We hope you enjoy it!
Organs-on-chips: into the next decade rdcu.be/b61sC - a new review by @drlucieinthesky and colleagues at @ncats_nih_gov discusses current applications and caveats for the use of organs-on-chips in drug discovery and offers suggestions for future research directions
Hughes Lab - UCI retweeted
Are ready for #NAVBO2020 ONLINE? Oct 26-29, 2020!
Tons of great talks, posters, networking and awards opportunities! Don't miss out! 😀
Register here: navbo.org/events/vb2020/vb20…
Check out the program here: navbo.org/events/vb2020/vb20…
Hughes Lab - UCI retweeted
I am thrilled that #NaomiChesler has joined @uci_bme and will be leading @UCIrvine's Edwards Lifesciences Center for Advanced Cardiovascular Technology. Welcome!
Naomi Chesler to Lead UCI Edwards Lifesciences Center for Advanced Cardiovascular Technology engineering.uci.edu/news/202…
Hughes Lab - UCI retweeted
How does the immune system work? Will there be #COVID19 vaccines? @BioRender & I put together ‘immunology 101 tweetorial for non-immunologists’. @jerryguartist, @shizaoki, @JungHeeSciViz also made this accompanying video. Please share widely! (1/n)
youtu.be/jeN8v5I5VNA
Hughes Lab - UCI retweeted
....looking beyond endothelial cells, Christer Betsholtz proposes the "COVID-19 pericyte hypothesis" based on prominent expression of ACE2 by pericytes (biorxiv.org/content/10.1101/…). Both fascinating & worth reading articles. Much more to be learnt about blood vessels and Sars-Cov-2.
Hughes Lab - UCI retweeted
Interesting literature: Peter Carmeliet & colleagues discuss the involvement of endothelial cells in the pathogenesis of COVID-19 (nature.com/articles/s41577-0…) and potential vascular normalization therapeutic modalities, including ongoing anti-Angiopoietin-2 clinical trials....
