Looking for an easy way to stay up to date on all things #IntestinalCell News? 🧐 Check out the Science News website by @STEMCELLTech and subscribe to our regular newsletters covering the latest research, reviews, industry news, and more. 👇 bit.ly/4kkWMEu

📢 New research supports CLDN1 as a candidate colorectal cancer-associated marker linked to malignant epithelial-cell states, tumor-associated spatial heterogeneity, invasive phenotype, and Nutlin-3a (−) response. #OpenAccess👉 : bit.ly/3WpqmkO #ColorectalCancer #IntestinalResearch

Metabolic plasticity enables #ColorectalCancer (CRC) cells to adapt to energy stress, contributing to #tumor progression and therapeutic resistance. 💡Results from a study in Biochemical Pharmacology provide mechanistic insight into the #anticancer activity of aripiprazole and support targeting metabolic plasticity as a therapeutic strategy for #CRC! Find out more: bit.ly/486Wr3v

Findings in this study (@cellhostmicrobe) identify Gemella morbillorum as a candidate onco-pathogen in #ColorectalCancer that uses multiple mechanisms to disarm the #intestinal barrier and trigger genotoxicity. #OpenAccess🔗: bit.ly/4icn1gh

Findings from this study in @NatureMicrobiol reveal #bacterial interactions regulating #intestinal function and a potential clinical therapeutic approach to preventing outcomes of #enterotoxigenic Bacteroides fragilis colonization. Find out more: go.nature.com/4jieIBO

Data from this study in @sigtrans_sttt reveal a Paneth cell-intrinsic endoplasmic reticulum stress mechanism linking ATZ accumulation to gut epithelial dysfunction, highlighting a previously underexplored role of the gut–liver axis in AAT deficiency. Read the #OpenAccess paper: go.nature.com/4ihLu4W #PanethCell #EndoplasmicReticulum #IntestinalResearch

Findings from a new study in @cgtnature suggest that targeting the m6A modification pathway holds promise for gastric cancer therapy, as the newly identified METTL3-E2F2-MCU axis plays a key role in regulating mitochondrial calcium homeostasis! 🔗 go.nature.com/47EWDqu #GastricCancer #IntestinalResearch #Mitochondria

Researchers from @UChicago built a comprehensive atlas of cell-type-resolved #chromatin accessibility which provides a comprehensive resource to study gene-regulatory effects in #CrohnsDisease and health. This atlas in @NatureGenet highlights the cellular complexity underlying Crohn’s disease risk. 🔗 go.nature.com/4dhy8mu

Findings from a study in @jlipidres suggest that loss of ceramide synthases 5/6 exacerbate myristate-induced intestinal endoplasmic reticulum stress in colon epithelial cells. Find out how accumulation of dhsphingosine may provide protection in the #OpenAccess paper here: bit.ly/4hEXa0a #Colon #EpithelialCells #EndoplasmicReticulum

Study findings reveal an intestinal effector-triggered immunity guard system that couples pore-forming toxin-damage sensing to comprehensive epithelial recovery, with physiological relevance for mucosal homeostasis across metazoans! Read the #OpenAccess paper here: bit.ly/4xWHuM7 #IntestinalResearch #Immunity

Scientists summarized the key intercellular dialogs that regulate fibroblast-to-myofibroblast transition during the onset and progression of intestinal disorders, further analyzing their regulatory mechanisms. 🔍Read the review: bit.ly/47jaouN #IntestinalResearch #FMT

Scientists from @PennMedicine present a retrospective review 📝 of #intestinal tract biopsies from patients treated with various cellular #immunotherapies (BCMA and CD19-directed CAR T, teclistamab and rituximab therapies). 🔗 bit.ly/4xJmoAI #OpenAccess

Researchers synthesized recent evidence to propose an updated framework for early gastric carcinogenesis based on field evolution, lineage instability, ecosystem support, and pathway divergence. Check out this review 👀: bit.ly/3TKyOdy

Findings point to the potential of dietary compounds 🥗 to modulate #IntestinalStemCells as a strategy to alleviate colorectal lesions. Learn more: bit.ly/4Ap91rT

🔬 Scientists identified functional zebrafish intestinal #StemCells in the proliferative zone of intestinal furrows that can differentiate into nearly all characterized epithelial cell lineages. Read the #OpenAccess article in @CellReports here: bit.ly/4haXxQ2.

Scientists from The Chinese University of Hong Kong show that the bacteria Agathobacter rectalis has anti #CRC effects in vitro and in vivo! 🦠 Read more in their #OpenAccess article: bit.ly/4xkCtMP.

Read this review which systematically analyses how cAMP response element modulator facilitates #UlcerativeColitis. 🧐 🔗 bit.ly/4h1WrGf

Extracellular vesicles (EVs) from multiple sources regulate intestinal homeostasis and #inflammation. In this review, read how EVs show promise as biomarkers and targeted therapeutics for precision #IBD care! 🔗 bit.ly/3VjRNfg

🤩 The first patient has been dosed in the phase 1 trial evaluating BHB810, a novel drug for the treatment of #GastricCancer! 🖥️ BHB810 was engineered using @BigHatBio's AI-powered antibody design platform, read more: bit.ly/4zSTjoz

🩺The @FDA has approved @BeOneMedicines's TEVIMBRA®-based regimen for the first-line treatment of adult patients with HER2-positive (HER2+) gastric, gastroesophageal junction, or esophageal adenocarcinoma (#GEA)! More info 👉 bit.ly/4xfEgD6

It's a major challenge to select effective chemotherapy after immunotherapy in #GastricCancer🤔. That's why scientists at Sun Yat-Sen University created an immune-activated co-culture model of gastric cancer organoids to develop personalized screening strategies! 📖 Read more about this study: bit.ly/464xu7T