Our October issue is now live! Get ‘wrapped’ up in this month’s exciting microbiology. cell.com/cell-host-microbe/c…

Phage small RNA mimics chimeric guide to inhibit CRISPR-Cas9 rAcrIIA1 is phage-encoded chimeric crRNA-tracrRNA mimic that blocks Cas9 guide loading & DNA interference. This reprogrammable RNA guide enables genome editing, gene silencing & diagnostics cell.com/cell-host-microbe/a…

Discovering phage defense systems through modularity networks Modular organization of bacterial immune systems is used to ID phage defense systems. 3 systems in P. aeruginosa reveal strategies against jumbo phages & RM-like system w/additional components cell.com/cell-host-microbe/f…

Akkermansia enhances anti-PD-1 efficacy A. muciniphila attenuates macrophage efferocytosis to overcome PD-1 resistance in microsatellite-stable colorectal cancer (MSS CRC). Phase 1 trial supports microbiome modulation to improve immunotherapy in MSS CRC cell.com/cell-host-microbe/f…

Akkermansia protects against endometritis A.muciniphila protects against endometritis by driving tyrosol production, which reaches uterus & suppresses inflammation. Work reveals metabolite-mediated gut-uterus axis linking microbiota to reproductive health cell.com/cell-host-microbe/f…

Gemella morbillorum promotes CRC Colonization of the colon by G. morbillorum increases intestinal permeability, enables epithelial cell invasion, reshapes host lipid metabolism & triggers DNA damage, collectively accelerating colorectal tumorigenesis cell.com/cell-host-microbe/f…

C. auris turns skin immunity to its advantage Preview of @ScienceMagazine paper showing C. aurisoccupies hair follicles & exposes chitin, triggering IFN responses that remodel follicular keratinocytes to promote fungal persistence cell.com/cell-host-microbe/a…

Microbial chromatin remodeler drives cancer progression S.anginosus promotes gastric immune evasion via EVs delivering bacterial chromatin remodeler to host cells, co-opting TEAD1 to⬆️ZDHHC11 & stabilize PD-L1. Targeting axis potentiates anti-PD-1 therapy cell.com/cell-host-microbe/f…

Preview: When microbial biofilms build kidney stones C. glucuronolyticum-like bacteria are urinary pathobionts that promote CaOx crystallization via (1) degradcrystallization inhibitor hippuric acid & (2) biofilm-mediated crystal aggregation cell.com/cell-host-microbe/a…

Bacteria promote kidney stones C. glucuronolyticum-like bacteria enriched in urine of calcium oxalate stone patients & promote CaOx crystallization via hippuric acid degradation & biofilm formation. Hippuric acid prevents bacteria-driven crystallization cell.com/cell-host-microbe/a…

Protein landscape of chromatin domains in Plasmodium Resource provides comprehensive characterization of chromatin-associated proteins in P. falciparum, revealing insights into parasite gene regulation, transmission & cell cycle control cell.com/cell-host-microbe/f…

Dual sensing activates antiviral reverse transcriptase for membrane targeting Phage DNA binding proteins or dGTP activate DRT2 to synthesize repetitive neo gene by rolling-circle reverse transcription. Neo depolarizes bacterial membranes & induces death cell.com/cell-host-microbe/a…

Microbial signal rewires the adipose-ovary dialogue Preview of work showing gut microbial metabolite reprograms adipose ceramide metabolism to influence ovarian function. Reveals how inter-organ communication couples metabolic & ovarian dimensions of PCOS cell.com/cell-host-microbe/a…

Microbial IAM alleviates PCOS C. aerofaciens & metabolite indole-3-acetamide (IAM) mitigate polycystic ovary syndrome pathology via activating adipose HIF-2α-ceramide signaling. Probiotic strain producing IAM shows therapeutic efficacy in mouse PCOS model cell.com/cell-host-microbe/a…

Rewiring tryptophan metabolism for cancer immunotherapy Oral nanoplatform releases tryptophan & metabolism inhibitor. Redirects tryptophan toward immunostimulatory microbial indole pathway, blocks immunosuppressive kynurenine & elicits antitumor immunity cell.com/cell-host-microbe/f…

Mutant KRAS favors a microbe that signals back Preview of work examining interplay between tumor genetics & microbiome in CRC--showing mutant KRAS favors B. acidifaciens, which signals back through a SusF-ARHGEF2 axis to reinforce RAS-MAPK signaling cell.com/cell-host-microbe/a…

Featured Article: KRAS rewires tumor microbiome Mutant KRAS reshapes intratumoral microbiome, enriching B. acidifaciens, whose SusF protein stabilizes ARHGEF2 to amplify KRAS–RAF–MEK–ERK signaling & tumorigenesis. Targeting SusF or ARHGEF2 blocked effects cell.com/cell-host-microbe/f…

Encrypting the message: Bacterium turns host RNA into a target Preview of new work identifying bacterial effector from Legionella pneumophila that modifies not host proteins but messenger ribonucleic acid (mRNA) to dampen the host inflammatory response cell.com/cell-host-microbe/a…

Featured Article: Bacterial effector modifies host mRNA FadA from Legionella pneumophila binds host mRNAs & mediates 8-oxo-guanine (oxo8G) modifications that cause oxidative damage & inhibit translation, favoring bacterial replication/persistence cell.com/cell-host-microbe/f…

Pleiotropic roles of microbial bile acid metabolism in intestinal health & diseases Review on microbe-mediated modifications of BAs & AI-assisted pipelines for discovering metabolic reactions. Examination of BA functions &roadmap for BA-based therapeutics cell.com/cell-host-microbe/f…