Assistant Professor @ University of Hong Kong, School of Biomedical Sciences
Hong Kong
Joined January 2018
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Shih-Chieh (Jeff) Ti retweeted
Excited to share our latest work on high-resolution comparative RNA knockdown profiles of shRNA, CasRx, and PspCas13b systems! biorxiv.org/content/10.1101/…
Shih-Chieh (Jeff) Ti retweeted
Very pleased that after a rigorous (and lengthy) review process, our paper visualizing how myosin generated forces modulate actin filament structure for mechanosensitive recogntion by α-catenin has appeared in @Nature
nature.com/articles/s41586-0…
Shih-Chieh (Jeff) Ti retweeted
Very excited to share our latest preprint, where we visualize the impact of force on the catch bonding actin crosslinker α-actinin-4. Led by @alfredcchin, a great collaboration with Glen Hocky's lab.
biorxiv.org/content/10.64898…
Shih-Chieh (Jeff) Ti retweeted
Two weeks left to apply for a PhD with us at MRC-LMB in Cambridge. Join our team for an exciting project on transcription-coupled splicing to understand human gene regulation 🧬 Feel free to get in touch directly #PhD #cryoEM #biochemistry
www2.mrc-lmb.cam.ac.uk/stude…
Shih-Chieh (Jeff) Ti retweeted
🎉🎉We’re on the cover of @NaturePhysics!!
Here is the original paper nature.com/articles/s41567-0…
Shih-Chieh (Jeff) Ti retweeted
New online! The mechanochemical cycle of reactive full-length human dynein 1 bit.ly/3EIW4ku
Shih-Chieh (Jeff) Ti retweeted
Cytosolic CRISPR RNAs for efficient application of RNA-targeting CRISPR-Cas systems | EMBO reports embopress.org/doi/full/10.10… Our paper is out in @emboreports! 1/n
Shih-Chieh (Jeff) Ti retweeted
We are delighted to announce that the 3rd DivIDE Conference will take place from 22–25 September 2025 with a fantastic lineup of speakers.
Registration opens soon - stay tuned and help us spread the word!
We are looking forward to meet many of you in Barcelona! ☀️
Shih-Chieh (Jeff) Ti retweeted
Excited that the peer-reviewed version of our fascin structure paper is now out in @NatureSMB. Thanks very much to the referees for their constructive feedback. rdcu.be/d6Tct
Shih-Chieh (Jeff) Ti retweeted
Force-transducing molecular ensembles at growing microtubule tips control mitotic spindle size
nature.com/articles/s41467-0…
Shih-Chieh (Jeff) Ti retweeted
Our lab’s recent work uncovers why T2D patients are more susceptible to severe viral infections
Check it out here: authors.elsevier.com/a/1k1Jg…
Shih-Chieh (Jeff) Ti retweeted
Pleased to present our latest work, where we show that the cell-cell adhesion protein afadin coopts mechanically-regulated elements of the cadherin-catenin complex to drive cytoskeletal engagement. biorxiv.org/content/10.1101/…
Shih-Chieh (Jeff) Ti retweeted
We are pleased to share our latest preprint on bioRxiv! Led by graduate student @VostalLauren, we use chemical proteomics to profile VCP-DUB interactions in living cells. We identify DUBs that bind the entry, exit, or both sites of VCP's central pore.
biorxiv.org/content/10.1101/…
Shih-Chieh (Jeff) Ti retweeted
Excited to present a new story, where we use purified proteins to reconstitute repair of mechanical damage in contractile actin networks by the LIM domain protein zyxin.
Shih-Chieh (Jeff) Ti retweeted
"Here, we describe our efforts to illuminate RNA biology through the application of chemical tools, focusing on post-transcriptional regulatory mechanisms."
Enabling technologies from @KleinerLabRNA
pubs.acs.org/doi/10.1021/acs…
#tbt
#ACSChemicalBiology
#methods
@PrincetonChem
Shih-Chieh (Jeff) Ti retweeted
The program of the Plant and Microbial Cytoskeleton GRC is online: grc.org/plant-and-microbial-…
Lots of opportunities for short talks!
Re-tweet and submit your abstracts!
#cytoskeleton #actin #microtubules #septins
#yeast #plants #bacteria #archaea #protists
Shih-Chieh (Jeff) Ti retweeted
Harriet Saunders, Cyntha van de Berg, et al. show how ciliary tip proteins cooperate to make slow growing #microtubules in their new preprint! Together they form a structure that looks like a champagne cork in a #microtubule 😍 biorxiv.org/content/10.1101/…
Shih-Chieh (Jeff) Ti retweeted
Talk/Poster/Earlybird registration deadline for the UK Microtubule meeting is the end of this week. 31st March 2024.
ed.ac.uk/biology/microtubule
Shih-Chieh (Jeff) Ti retweeted
The annual @ASCBiology #cellbio2023 meeting calls for a lab reunion! It was great to see many former lab members at the meeting, where we caught up for a fun dinner! @stforth @kuohsia @rudypisa @JeffTiLab @ZhenChentccz
