@JulianTrouillon

Junior Group Leader at @ETH Zürich 🇨🇭 - Transcription factors, Bacterial regulatory networks -

 Zurich, Suisse
imsb.ethz.ch/research/trouillon.html
Joined March 2017
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  • Following242
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🥳 New preprint! 🥳 While planning molecular screening experiments, we went deep down a rabbit hole on group testing strategies to improve throughput. We present PoolPy, a tool to facilitate the design of pooled experiments. arxiv.org/abs/2509.03481
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This is still preliminary, we're happy to take feedback! Poolpy is also available as a web app: trouillon-lab.github.io/Pool…
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🥳 New paper out! In this work, we identified small molecule effectors modulating the activity of transcription factors in E. coli. Using metabolomics + transcriptomics, we could parse the entire regulatory network and predict signal molecules for 41 TFs! embopress.org/doi/full/10.10…
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Replying to @sammy_pontrelli @VIB_microbes
Here's our lab website: pontrellilab.sites.vib.be/en

Lab of Microbial Metabolic Interactions | Pontrelli lab

pontrellilab.sites.vib.be
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We are searching for a postdoc in Marine Phytoplankton Metabolism and Carbon Storage! You'll get the chance to combine high-throughput metabolomics and enzymes to study how microbes naturally sequester atmospheric carbon in dissolved organic molecules! jobso.id/m9nq
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Julian Trouillon retweeted
Zampieri Lab@ZampieriLab28 Jan 2025
We are very excited to share new recent research from our lab! This has been a long-time effort, involving several fantastic group members and collaborators (@pedrobeltrao and @Jürgen) with @LaurentzSchuhk1 on the driving sit.
Nature Biotechnology
@NatureBiotech28 Jan 2025
A human metabolic map of pharmacological perturbations reveals drug modes of action go.nature.com/3CreANg
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I have an open Postdoc position in Molecular Systems Biology at ETH Zürich! The project is about the conservation of transcription factors functions between strains of Pseudomonas aeruginosa 🧬🦠 More details and application at: jobs.ethz.ch/job/view/JOPG_e… Please share!
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Sager Gosai@SagerGosai25 Oct 2024
I’m thrilled to share that our paper “Machine-guided design of cell-type-targeting cis-regulatory elements” was published online in @Nature. nature.com/articles/s41586-0… #genomics #MachineLearning #SyntheticBiology #bioengineering 1/9

Machine-guided design of cell-type-targeting cis-regulatory elements

Nature - A generalizable framework to prospectively engineer cis-regulatory elements from massively parallel reporter assay models can be used to write fit-for-purpose regulatory code.

nature.com
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I'm hiring another postdoc for my starting lab at @VIB_microbes to study microbial carbon fixation! We'll be deriving how enzymes in marine microbes inadvertently form stable molecules that are sequestered long term in the ocean. jobs.vib.be/j/93444/postdoc-…
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I have an open position for a PhD student in molecular microbiology! The project is about the role of transcription factors during P. aeruginosa infections 🦠🧬. More details: imsb.ethz.ch/research/trouil… Please share!
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If you're interested in bacterial pathogens, transcriptional regulatory networks and/or sequencing-based approaches, reach out! The starting time is somewhat flexible, my group will start at ETH Zürich at the beginning of 2025.
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My lab is searching for a postdoc in microbiology/microbial metabolomics! Are you a biologist who is secretly realizing you might be a mass spec nerd? If so, I can relate and I'd love to work with you! Please check out more details here: jobso.id/j6x1
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Super excited to announce that I obtained an @snsf_ch Ambizione grant to start as a junior group leader at @IMSB_ETH at ETH Zürich! 🥳 We will study transcription regulatory networks in bacterial pathogens 🧬 Will soon advertise positions for a PhD student and Master projects!
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I’m excited to announce that I’ll join VIB-KU Leuven as a professor starting 2025. My lab will study how marine microbes capture CO2 and sequester it in ancient ocean molecules, taking an approach that combines microbiology, high throughput metabolomics and biochemistry.
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Julian Trouillon retweeted
nature
@Nature10 Jul 2024
Nature research paper: In situ targeted base editing of bacteria in the mouse gut go.nature.com/3VW8iuJ

In situ targeted base editing of bacteria in the mouse gut

Nature - Edited bacteria were stably maintained in mouse gut for at least 42 days following the delivery of a base editor using an engineered phage-derived particle to modify Escherichia coli...

nature.com
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Today in @ScienceMagazine, we report how a bacteria has evolved into a major human pathogen over the last 200 years. Read on, this is going to be an adventurous ride 1/n! science.org/doi/10.1126/scie…

Evolution and host-specific adaptation of Pseudomonas aeruginosa

The major human bacterial pathogen Pseudomonas aeruginosa causes multidrug-resistant infections in people with underlying immunodeficiencies or structural lung diseases such as cystic fibrosis (CF)....

science.org
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Julian Trouillon retweeted
Cameron Thrash@jcamthrash10 Jun 2024
The Pangenome of Escherichia coli biorxiv.org/content/10.1101/…

The Pangenome of Escherichia coli

Thousands of complete genome sequences for strains of a species that are now available enable the advancement of pangenome analytics to a new level of sophistication. We collected 2,377 publicly-av...

biorxiv.org
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Julian Trouillon retweeted
Snijder Lab@snijderlab7 Jun 2024
Our big story on the importance of "stripy" T cells in antigen response, which started as a MSc Thesis 6 years ago, has finally made its way out in @ScienceMagazine! 🤩 Massive congrats to @BenHale95 & thanks to all collaborators particularly @LabOxenius & @blutspendesrk 🥰
Sarah Ross@sarah_h_ross6 Jun 2024
Out now @ScienceMagazine: @BenHalePhD, @BerendSnijder & colleagues report that the internal architecture of T cells at the moment they are activated can influence their fate in response to antigen. 🔗science.org/doi/10.1126/scie…
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Cool work on E. coli transcription factors! biorxiv.org/content/10.1101/…

Predictive Biophysical Neural Network Modeling of a Compendium of in vivo Transcription Factor DNA...

The DNA binding of most Escherichia coli Transcription Factors (TFs) has not been comprehensively mapped, and few have models that can quantitatively predict binding affinity. We report the global...

biorxiv.org
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Julian Trouillon retweeted
Ricard Solé@ricard_sole19 Apr 2024
Is biology predictable? This is a hard problem, relevant across scales, from conservation to the human microbiome. Check this @NatureRevMicro paper by @AllisonLopatkin & James Collins. @BCNCollab @vdlorenzo_CNB @manlius84 @Daniel_R_Amor static1.squarespace.com/stat…
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