St. Jude scientists identified a direct role for PARP1 in chromatin remodeling, revealing for the first time how the protein partially disassembles nucleosomes to make damaged DNA accessible for repair. The findings could lead to more targeted PARP1 inhibitors and potentially reduce treatment toxicity. bit.ly/4zRmFDb

Researchers have mapped 117 kinases capable of phosphorylating the RNA polymerase II tail, revealing modifications at previously disregarded positions beyond amino acids two and five. This discovery expands our understanding of gene transcription control. ow.ly/crFR50Xo1en

Scientists used cryo-EM to capture 13 distinct structures of the chromatin remodeler SNF2H in action. This research provides a complete view of nucleosome sliding, a key process in gene regulation. ow.ly/mhv150VtUoH