Birmingham, England
Joined June 2018
3 days of outstanding talks from ⁦@IcgsUob⁩ PhD students, well done everyone. Winners of best 3rd year talk and receiving conference travel funds are Tom Starkey and Paige White from ⁦@beggs_lab⁩ ⁦@ferencmueller⁩ labs. congratulations to you both 🎉
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Please check out our paper in Developmental Cell (bit.ly/2Pu7xdP) on the 2 phases of chromatin accessibility and genome activation in zebrafish PGCs. By @FabioDorazio with @PiotrBalwierz @Circe777 and contributions @splendidsunjane B Cairns @vaquerizas @BorisLenhard labs
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We started the this project with the ambitious goal of studying how the germ line links generations at the beginning of life. Now I like to think that goal is achieved and we better understand how the germ line forms. Great thanks to all co-authors
Please check out our paper in Developmental Cell (bit.ly/2Pu7xdP) on the 2 phases of chromatin accessibility and genome activation in zebrafish PGCs. By @FabioDorazio with @PiotrBalwierz @Circe777 and contributions @splendidsunjane B Cairns @vaquerizas @BorisLenhard labs
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Replying to @the_Node
here is the single figure abstract
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Mueller Lab retweeted
Learn more about the regulation of transcription in primordial cells in the lab's latest preprint #BSDBGenSoc2020 biorxiv.org/content/10.1101/…
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Our ms on regulation of transcription in primordial germ cells is out in BioRxiv bit.ly/2tTXmoi led by @FabioDorazio @PiotrBalwierz with @vaquerizasjm @BorisLenhard B. Cairns lab #ZencodeITN #pgc #generegulation. See related study bit.ly/2sogBFX by @KettingLab
Our new work on distinct transcription initiation regulation by cell cycle dynamics @zebrafish in bioRxiv: tinyurl.com/weaplrd by @j_wragg_bham with L Roos, @ncvetesic @BorisLenhard lab #generegulation
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Our paper with @ChiragNepal and @BorisLenhard, @Carninci, Peers and Andersen labs is out in Nat Comm Go.nature.com/2QR1gHf. Novel class of core promoters: dual initiation promoters facilitate distinct posttranscriptional processing of transcripts in fish, fly and humans.
Mueller Lab retweeted
Our fish have all left @sangerinstitute and are now at @CamBioCampus. We humans join them in 20 days. If you're interested in chromatin and want to come too then you've got about 24 hours to apply for jobs.cam.ac.uk/job/22839/
All this in 2 months.... 9/10 women PIs. #icgs ⁦@unibirm_MDS⁩ #genomebiology ⁦@Morris_Lab_DSBs⁩ ⁦@AgaGambus⁩ ⁦@ColemanLab⁩ ⁦@LabMueller⁩ ⁦@EvaPetermann⁩ ⁦@UoBWomensNet⁩ ⁦@LabMonteiro⁩ ⁦⁩ ⁦@HPVsupergroup⁩
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Great to see the C1 single cell CAGE finally out. CAGE allows profiling capped mRNA expression and simultaneous single-base resolution mapping of their promoters, as well as promoters of lncRNAs and enhancer RNAs. This work... nature.com/articles/s41467-0…
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1/ Excited to announce our latest work looking at the role of transposable elements in regulating 3D chromatin during early mammalian development, out now in @biorxivpreprint @vaquerizas_lab #3DGenome #transposons #early_mouse_development biorxiv.org/content/early/20…
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Just over 2 weeks to go until the application deadline of 20 January for the 2019 intake.
We are delighted to announce that applications are now open for the 2019 intake to the MRC IMPACT programme! Full details and the application form can be found on the IMPACT website more.bham.ac.uk/mrc-impact/p… @krobinson204 @uniofleicester @tennantlab
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News & Views: A study in Nature reports that in the nuclei of mouse olfactory sensory neurons, certain regions of multiple chromosomes assemble in a structure that controls the expression of the full repertoire of olfactory-receptor genes in the nose. go.nature.com/2SP9gHl
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Happy to share our latest pre-print! Great work @DobrzyckiTomasz, Monika K and collaborators! A zebrafish model for MonoMAC syndrome identifies an earlier role for gata2 in haemogenic endothelium programming and generation of haematopoietic stem cells biorxiv.org/content/early/20…
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Excited to share our preprint on human islet 3D genome maps Thx to many... @irene_miguelesc @sbguarch Ines Cebola @Geek_y J Ponsa D Rolando @Peter_Fraser1 @BiolaMJavierre @mamartirenom @iosonoirene T Hansen @Inga_genetics @josep_mercader L Pasquali et al biorxiv.org/content/early/20…
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Please RT We're hiring 2 postdocs (1 computational , 1 lab) to work in @ERC_Research project Contact me if you're interested in regulatory genomics, and want to use it to solve disease mechanisms and find therapeutic targets. Ads out soon @CRGenomica
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Here's my official welcome to @unibirm_MDS ! Looking forward to new discoveries in my new lab! Interested? Get in touch!
#HaveYouMet Dr Rui Monteiro? Rui has joined the Institute of Cancer and Genomic Sciences and hopes to contribute to new discovers that will revolutionised our understanding of the biological process of making blood stem cells #MDSBirminghamFellow birmingham.ac.uk/research/ac…
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Remarkable "3D histology" of zebrafish at cellular resolution using uCT from @kcheng76 and colleagues. Preprint: biorxiv.org/content/biorxiv/… Web interface: 3d.fish Check out your favorite structures!
A paper in Nature finds that CRISPR-guided DNA polymerases enable multiplexed and continuous diversification of user-defined genomic loci, which will be useful for a broad range of basic and biotechnological applications go.nature.com/2AE57l4
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