Studying protein degradation at The University of Queensland 🧫🔬
Brisbane, Australia
Joined January 2020
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Check out our preprint showing that the turnover of NIX and BNIP3 mitophagy receptors via SCF-FBXL4 ligase keeps mitophagy low.
biorxiv.org/content/10.1101/…
Julia Pagan Lab retweeted
Very (very!!) happy to share our latest publication, "PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy", out today in @NatureComms. 1/n nature.com/articles/s41467-0…
First PhD completed in our lab!! We are so proud of you Dr @DienGiang , your hard work has paid off! 👩🏻🎓🥳 – at Brisbane, Queensland
Julia Pagan Lab retweeted
Late to the Twitter party, but wanted to highlight this excellent study from @LabPagan that provides fundamental insights into how mitophagy is regulated. An elegant mechanism that puts ubiquitin at the centre stage -this from a pathway that is meant to be ubiquitin independent!
Check out our preprint showing that the turnover of NIX and BNIP3 mitophagy receptors via SCF-FBXL4 ligase keeps mitophagy low.
biorxiv.org/content/10.1101/…
Julia Pagan Lab retweeted
Really, really humbled to have had the opportunity to work closely with @DienGiang on this project! 🧫
Go check out some of the cool things we saw! – at Brisbane, Queensland
Check out our preprint showing that the turnover of NIX and BNIP3 mitophagy receptors via SCF-FBXL4 ligase keeps mitophagy low.
biorxiv.org/content/10.1101/…
Julia Pagan Lab retweeted
Really nice study from the lab of Julia Pagan showing a central role for the F-box protein FBXL4 in ubiquitation and degradation of mitophagy regulators BNIP3 and NIX. @LabPagan. @UQ_News biorxiv.org/content/10.1101/…
Many thanks to the amazing first authors @DienGiang + @KeriKozul and our wonderful collaborators including @brettcollins100 @LabParton @paganolab @ZurynLab @LazarouLab @Jones_MJK @_AntonioMarzio Robert Taylor @MitoResearch
Sylvie Urbe and Michael Clague's group independently discovered the same mechanism and you can read their preprint too! biorxiv.org/content/10.1101/…
Julia Pagan Lab retweeted
A cell videoed through a microscope. DNA in the nucleus (blue), mitochondria (yellow), and the cytoskeletal protein VASP (purple) are shown.
#CellBiology #microscopy #SciArt
Join us for this awesome event!
11th Brisbane Cell and Developmental Meeting 22nd April 12-4 pm. Presentations by Dr Sarah Boyle, A/Prof Matt Francois, A/Prof James Hudson and Dr Jana Vukovic. Hosted at TRI and on Zoom. Free post-meeting networking event for Brisbane members. Register at form.jotform.com/21065870149…
Julia Pagan Lab retweeted
Checkout our paper describing DDK’s role in human replication and fork repair. Online now @MolecularCell Many thanks to my coauthors @GelotCam @jallepap @jespervolsen authors.elsevier.com/c/1cX5a…
A fun lab celebration playing Christmas themed putt putt @VicParkGC!🎄🎅🏼 Scientists and swinging candy canes were an interesting mix...
Julia Pagan Lab retweeted
A peculiar bacterial enzyme has allowed researchers to achieve what even the popular CRISPR–Cas9 genome-editing system couldn’t manage: targeted changes to the genomes of mitochondria, cells’ crucial energy-producing structures. go.nature.com/2ZtWSTa
Julia Pagan Lab retweeted
Mitochondria, the powerhouses inside cells, have been gene-edited for the first time bit.ly/2ZMzbEs
Julia Pagan Lab retweeted
A handful of genetic and structural analyses have identified a key feature of #COVID19 — a protein on its surface — that might explain why it infects human cells so readily. go.nature.com/3aGqFdQ
Julia Pagan Lab retweeted
News & Views: A process termed ubiquitination mediates the regulated destruction of cellular proteins, thereby preventing disease or infection. Structural data now reveal how a crucial regulator of ubiquitination enzymes coordinates this process. go.nature.com/31UEVfT
Julia Pagan Lab retweeted
A useful review of mitochondrial E3 Ubiquitin Ligase PARKIN: Relationships with other causal proteins in familial #Parkinsons & its substrate-involved mouse models
mdpi.com/1422-0067/21/4/1202…
