Dedicated physicians & scientists determined to improve outcomes in patients with gastrointestinal cancers through basic and translational research @DanaFarber
Boston, MA
Joined November 2020
- Tweets286
- Following1.3K
- Followers496
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Sethi_Lab retweeted
Congratulations to @MuzumdarLab and @SStevenWang, recipients of an @theNCI #R33 award, which they will use to develop #RAEFISH, an innovative spatial transcriptomics technology.
medicine.yale.edu/cancer/new…
@SmilowCancer @YaleGenetics
Sethi_Lab retweeted
It is so exciting to build the understanding of the function differences between EP300 and CBP, which can be applied to target specific therapy development.
This was a major effort between the @Adurbinlab @TheAbraLab @JunQiLab and the Ory labs. We pick up on a long-term interest of our labs: the attractive target, EP300. EP300 is a great cancer target because while many tumor cells require it, they often may not need its paralog CBP
Sethi_Lab retweeted
Interested in studying the origins of lung cancer and regulation of development, cell fate, metabolism in human lung progenitors? All in a rigorous, science-loving, supportive environment?
I'm looking for postdoctoral fellows, students, technicians! DM me.
Please retweet!
Sethi_Lab retweeted
A New Era for Colorectal Cancer Care at MD Anderson - Scott Kopetz
@skopetz
oncodaily.com/industry/scott…
Beautiful study by the @Oser_Lab! Crispr screen applied to custom reporter revealed HUWE1 is a stability regulator or ASCL1, lineage TF driving a major subtype of SCLC. Then base editor screens identify functional domains, including an uncharacterized IDR. Elegant and rigorous!
Excited to share another new study from our lab, co-led by Keita Masuzawa and Kevin Dong: “A HUWE1 Regulatory Helix Gates ASCL1 Degradation Through Its C-Terminal Phospho-Degron in Small Cell Lung Cancer.”
genesdev.cshlp.org/content/e…
We appreciate the support from @DanaFarber and are grateful to the patients who participated.
A new study in @jclinicalinvest led by @danafarber’s @labsethi sheds light on therapy-associated polyposis, a rare condition that can develop decades after cancer treatment in childhood or young adulthood. For the first time, researchers identified lasting molecular evidence of genetic damage linked to chemotherapy in precancerous colorectal growths.
Read more here: bit.ly/4hIrB70
Increased dietary fats leads to more aggressive colorectal cancer via ceramide synthesis and YAP regenerative signaling. A metabolic memory of the exposure persists. science.org/eprint/UAMCP9BAE…
Our work on therapy-associated polyposis highlighted below by @jclinicalinvest . In childhood cancer survivors, we find that prior alkylating chemotherapy can leave durable mutational scars in the colon that remain detectable decades later in precancerous polyps.
Therapy-associated polyposis (TAP) is a rare condition that arises decades after treatment for childhood and young adult cancers. doi.org/10.1172/JCI201216
In this Research Letter, Nilay S. Sethi @Nilay_Sethi & team reveal a mutational signature strongly linked to alkylating chemotherapy exposure in childhood cancer survivors, reporting chemotherapy leaves lasting DNA scars in precancerous colon polyps. Paired patient organoids establish an experimental model for further studies.
@labsethi @DanaFarber
#ChildhoodCancer
Grateful to the patients, collaborators, and team who made this study possible. @MattYurgelun
#ChildhoodCancer #CancerSurvivorship #ColorectalCancer #polyposis
Sethi_Lab retweeted
Congratulations to @DanaFarber’s @nickpolizzi_ and @XinGu0317 who have received New Innovator Awards from the @NIH High-Risk, High-Reward Research program which supports early career investigators pursuing highly innovative research with potential for broad impact on biomedical and behavioral science. @DFCI_CancerBio
Read more: bit.ly/4hKLs46
Sethi_Lab retweeted
Exposure to high dietary fat increases ceramides and promotes cancer metastasis @ScienceMagazine @SwagataGoswam16 @EinsteinMed @ohyilmaz @Nilay_Sethi @DanaFarber
science.org/doi/10.1126/scie…
Sethi_Lab retweeted
How Dietary Lipids Can Shape Colorectal Cancer Cell Behavior? - Swagata Goswami (@SwagataGoswam16)
oncodaily.com/science/swagat…
A wonderful study to be part of. Thanks for including us @ohyilmaz!
What gives some colorectal cancer cells the ability to metastasize? In our new paper, we find that tumor-intrinsic ceramide synthesis is a metabolic switch for metastatic initiation. 🧵 Free access: science.org/eprint/UAMCP9BAE…
Sethi_Lab retweeted
Now out in @ScienceMagazine! What gives some colorectal cancer cells the ability to spread? We found that ceramides made by cancer cells help activate a reparative program to metastasize.
@qiming_kelly @ohyilmaz @Aslan_Tasdogan @UpasanaDA @aburakyildiz
science.org/doi/10.1126/scie…
Sethi_Lab retweeted
Very relevant finding for folks using CRISPRi in iPSC-derived neurons from @ophirshalem & team.
Happy to share the revised and now published in Cell Systems version of our paper, where we explore why dCas9-KRAB(KOX1) protein levels drop so drastically after neuronal differentiation in WTC11 and KOL2.1J iPSC lines.
Paper: doi.org/10.1016/j.cels.2026.…
Sethi_Lab retweeted
Finishing your PhD or looking for a post-bac research position? We’re recruiting multiple postdocs and research technicians to study somatic evolution!
Come do interdisciplinary science in a friendly, collaborative environment at @harvardmed Genetics.
naxerova.hms.harvard.edu/con…
Sethi_Lab retweeted
Zenocutuzumab offers a new targeted treatment option for patients with previously treated, advanced NRG1 fusion-positive cholangiocarcinoma. @DanaFarber's James Cleary, MD, PhD, discusses in @OncLearnNetwork the approval and the role of comprehensive molecular testing. bit.ly/4h0u3Wy
Sethi_Lab retweeted
Advanced fellowship in leukemia @DanaFarber
for 2027-2028, application is open. jobcenter.hematology.org/job…