@LauraReale12

Postdoctoral research fellow in the Rothstein Lab | Johns Hopkins University School of Medicine | Researching neurobiology and neurodegeneration

 Baltimore, MD
Joined January 2021
  • Tweets56
  • Following248
  • Followers222
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Very happy to share my first paper that is in press at Progress in Neurobiology with @DrCathBlizzard @MarcusDyer14 @LabGlial and Twitterless Sharn Perry, Adele Woodhouse and Tracey Dickson. sciencedirect.com/science/ar…
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Delighted to share our paper on the influence of the #NodeOfRanvier on in vivo #axonaltransport of #mitochondria and #signallingendosomes @iScience_CP @SchiavoMNPlab @J_N_Slayer @samuscientist. A project that started in 2018 but has finally seen the light of day!
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Great to see Tram's paper online showing that rTMS increased interneuron activity following demyelination and increased remyelination by new and surviving oligodendrocytes. Thanks to coauthors including @DrCarlieCullen , @AlastairFortune , @LauraReale12 , @Tomlewis2310 .
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So excited to start my post-doc in the @Rothstein_Lab!!
Rothstein Lab@Rothstein_Lab26 Jun 2024
Today, we had a lab dinner to welcome @LauraReale12 to our group as a postdoctoral fellow!
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Very excited to share our new pre-print using human iPSC-derived organoids containing extensive, mature myelin and functional microglia to model demyelination and oligodendrocyte/myelin regeneration #organoids #MS biorxiv.org/content/10.1101/…

A Human iPSC-derived Organoid System to Model Myelin Destruction and Repair

We engineered a novel human iPSC-derived organoid system enriched with mature, myelinating oligodendrocytes and functionally reactive microglia. This model enables the study of human CNS remyelinat...

biorxiv.org
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Big thanks to the team making this work possible where we used our biochem to diagnose a patient with a new SOD1 variant. Personally, my most meaningful work to date, helping a patient understand their condition. tandfonline.com/doi/full/10.… @MolHorizons @uowresearch

Rapid classification of a novel ALS-causing I149S variant in superoxide dismutase-1

Variants of the oxygen free radical scavenging enzyme superoxide dismutase-1 (SOD1) are associated with the neurodegenerative disease amyotrophic lateral sclerosis (ALS). These variants occur in ro...

tandfonline.com
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NEW PAPER: We generated Oligodendroglial Progenitor Cells (OPCs) from hiPSCs harboring FUS mutations. Our results demonstrated the pathological role of mutant FUS in OPCs, highlighting the significance of glial cells in FUS-ALS. link.springer.com/article/10…

Disruption of MAM integrity in mutant FUS oligodendroglial progenitors from hiPSCs

Acta Neuropathologica - Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and fatal neurodegenerative disorder, characterized by selective loss of motor neurons (MNs). A number of...

link.springer.com
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If you'd like to hear about how rare genetic variants associated with MS can cause motor dysfunction and cellular changes within the brain, come by my talk this Wednesday!
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Our new Perspective on non-invasive brain stim (particularly rTMS) is out! Explore how recent research shows plasticity, network, and cell-type specific mechanisms & how to leverage animal studies to refine our understanding and application of rTMS/tES. journals.lww.com/nrronline/f…

Working toward an integrated plasticity/network... : Neural Regeneration Research

Abstract was not provided for this article.

ovid.com
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I'll be sharing our latest results tomorrow as part of the @FightMND Scientific Seminar series. Register using the link: fightmnd.org.au/fightmnd-sci…
FightMND@FightMND19 Sep 2023
Join us on September 26 to hear from our inaugural FightMND Early Career Research Fellow Dr @Rebecca_SanGlia, from the @UQ_News on the topic of protein signatures of TDP-43 proteinopathies in the brain. For more information or to register visit fightmnd.org.au/fightmnd-sci…
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Today I passed my first major milestone of my PhD 🎉 looking forward to the next 3 years! Many thanks to my wonderful supervisory team @DrCathBlizzard 🌟 @MND_RIA
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Laura Reale retweeted
Ilary Allodi@AllodiLab4 Jul 2023
Very happy to see our mini review out today in ⁦@FrontiersIn⁩ in Neural Circuits! ⁦Written by @Santi_Mora_⁩ and myself 😎 doi.org/10.3389/fncir.2023.1…
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Tassie MND researchers join forces for #mndweek2023 and cake. Thanks @AndrewPhipps20 for organising. Don't fear, my research skills are better than my cupcake skills.
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Our paper is out! We directly show that TDP-43 build up in neurons of the motor cortex can drive a hyper excitability phenotype that propagates through the corticomotor system to cause lower motor neuron death. Critical proof of concept!! Funded by @MND_RIA and @nhmrc
Laura Reale@LauraReale126 Apr 2023
Very happy to share my first paper that is in press at Progress in Neurobiology with @DrCathBlizzard @MarcusDyer14 @LabGlial and Twitterless Sharn Perry, Adele Woodhouse and Tracey Dickson. sciencedirect.com/science/ar…
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This regional vulnerability was associated with alterations in pre-synaptic proteins, where an increase in excitatory inputs occurred in all lumbar regions, but in lumbar regions 4-6 where lower motor neuron number was normal, there was local upregulation of inhibitory inputs.
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This indicates the balanced excitatory/inhibitory inputs is protective for these cells.
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Interferon on my mind? Please come to my talk at 9:40-9:55am Hall G2, Thurs 30.03.2023 if interested. #ADPD2023 Also we have a postdoc position open at the Florey Institute 🇦🇺 #Neuflam @TheFlorey
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