Asst. Professor in @compbiopitt. Our lab is interested in cell fate decisions in embryos, noisy signaling and optogenetics.
Joined September 2021
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We’re very excited to share the first preprint from my lab along with @h4rrymcnamara, @BillZJia, @AdamEzraCohen, and Alex Schier. We describe a set of methods for exerting spatial control over Nodal signaling in zebrafish development.
biorxiv.org/content/10.1101/…
Very excited to be a small part of this awesome paper! Congrats @jishnu1729 and @poholeklab!
Excited to present SpaceTravLR, a new framework to uncover functional spatial microniches across contexts. We learn how individual & combinatorial genetic changes rewire regulation & cell-intrinsic + cell-extrinsic signaling across space in tissues. biorxiv.org/content/10.1101/… (1/2)
Nathan Lord retweeted
Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.
Also: check out the awesome accompanying paper from @GetYourChorion that uses our tools to pick apart how Nodal signaling dynamics inform morphogenesis!
journals.biologists.com/dev/…
We're very excited to have the final version of our paper up in @Dev_journal. We describe a new system for spatial control of Nodal signaling in live embryos. Thanks to Development for a helpful and constructive review process!
Please reach out if you'd like to try our tools!
Optogenetic control of Nodal signaling patterns
Read this Techniques & Resources Article by Harold McNamara, Alex schier, Adam Cohen, Nathan Lord and colleagues:
journals.biologists.com/dev/…
🎥Direct visualization of photopatterning of live zebrafish embryos
Nathan Lord retweeted
I wrote a 'Behind the Paper' blog post for @the_Node narrating the origin story of our recent @NatureCellBio paper on recording signals during gastruloid symmetry breaking. have a read if you're curious!
thenode.biologists.com/behin…
Nathan Lord retweeted
Read below for the latest from Emily Ho in my lab on in vivo receptor tyrosine kinase biosensors. This has been a *dream* project, seeing endogenous RTK activity in live embryos for the first time. Surprise: they don't always match those of downstream signaling pathways!
Have you ever wanted to *see* receptor activity in embryos? If so, our new preprint is for you! In it, we showcase a new live-cell biosensor for visualizing receptor tyrosine kinase activity in living embryos – pYtags!
biorxiv.org/content/10.1101/…
Nathan Lord retweeted
My team at Deepmind (protein design) is hiring an experimentalist with enzyme expertise. Please RT and/or apply! I'm happy to answer any questions as well. boards.greenhouse.io/deepmin…
Get in on the ground floor! Working with @h4rrymcnamara was a highlight of my scientific career. He is brilliant, creative, and a joy to work with. His lab is going to do awesome things. Definitely seek him out if you're looking to get into developmental biology for PhD/postdoc.
a personal update: in January, I'm moving to Yale to join @MCDB_Yale and to open my lab in the @WuTsaiYale Institute!
We will investigate multicellular self-organization using synbio tools to read and write developmental signals in stem cell models.
syndevbio.org/
Nathan Lord retweeted
Our paper “Dynamics of morphogen source formation in a growing tissue”
with first authors R. Ho and K. Kishi is published in @PLOSCompBiol 🎉
We show that the floor plate of the vertebrate neural tube forms in two phases: rapid specification followed by growth.
🧵1/7
Nathan Lord retweeted
What if you could find out the history of signaling activity in each cell with a single round of imaging? Wouldn't that be incredible? Well, we thought so too. And that's what we set out to achieve with INSCRIBE in our new preprint. Let’s dive in! 🚀🔬
biorxiv.org/content/10.1101/…
Nathan Lord retweeted
Working on this paper with @h4rrymcnamara was just an absolute pleasure, one of the highlights of PI life so far.
Even better: he'll be starting his own laboratory in just a few months at Yale - so stay tuned for more exciting work from the McNamara group!
Our study decoding gastruloid symmetry breaking is now live @NatureCellBio!
rdcu.be/dVMLG
Thank you to the NCB edititorial team and to our reviewers for a constructive review process which helped improve our study. A thread on updates (1/n):
Nathan Lord retweeted
Check out our latest preprint on FGF/ERK signaling in 2D gastruloids:
biorxiv.org/content/10.1101/…
