Immunologist, Book Lover, Wanderer
Joined March 2020
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- Following240
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Mukta Deobagkar retweeted
Interested in single cell genomics but need help getting started? Check out the full agenda for our Single Cell Genomics Day on Friday 4/25. All talks will be live-streamed (no registration required) at satijalab.org/scgd25
Mukta Deobagkar retweeted
Splenic fibroblasts control marginal zone B cell movement and function via two distinct Notch2-dependent regulatory programs dlvr.it/THPSV5
Mukta Deobagkar retweeted
New Garvan research reveals how hepatitis C triggers autoimmunity through B cell mutations – not molecular mimicry as previously thought.
Published in @ImmunityCP, this could transform treatment approaches for a range of autoimmune diseases.
ow.ly/uY1V50UHikb
Mukta Deobagkar retweeted
The molecular reach of antibodies crucially underpins their viral neutralization capacity
nature.com/articles/s41467-0…
@NatureComms @Dushek @annagesine
Mukta Deobagkar retweeted
Metagenomic immunoglobulin sequencing reveals IgA coating of microbial strains in the healthy human gut
@NatureMicrobiol @GutBugs2 @MattagenOlmics
nature.com/articles/s41564-0…
Mukta Deobagkar retweeted
Cao, Burrows, @nkg2d1 @theonlylabever et al. show that Tritrichomonas musculis-driven IgA modifies the commensal bacterial microbiota and improves the generation & dissemination of IgA-secreting plasma cells reactive against orally ingested food antigens. hubs.la/Q02Y4GM00
Mukta Deobagkar retweeted
New research from @YaleIBIO reveals that natural antibodies secreted by a subset of #Bcells prevent reactivation of endogenous #retroviruses in mice.
@VirusesImmunity @YYexin
Read more in Science #Immunology: bit.ly/3Z7Rd2L
Mukta Deobagkar retweeted
Integrin-αV restricts tissue-resident airway B cell responses by reducing persistence of germinal center reactions locally in the lungs, limiting lung-resident IgA+ memory B cells that are cross-reactive to antigenic variants
biorxiv.org/content/10.1101/…
Mukta Deobagkar retweeted
A must read!
The renaissance of oral tolerance: merging tradition and new insights | Nature Reviews Immunology nature.com/articles/s41577-0…
Mukta Deobagkar retweeted
If one believes in #TCR #crossreactivity, read this #1000times or even more. T Cell Receptor Cross-Reactivity between Similar Foreign and Self Pept... sciencedirect.com/science/ar…
Mukta Deobagkar retweeted
A two-shot #vaccine regimen, delivered a week apart in increasing doses, prolongs antigen capture and boosts T cell priming and #Bcell responses in mice.
Read more in Science #Immunology: scim.ag/8ni
Mukta Deobagkar retweeted
Monumental paper by Helen C. Su and collaborators, with profound biochemical, immunological, and clinical implications:
Germline mutations in a G protein identify signaling cross-talk in T cells | Science science.org/doi/10.1126/scie…
Mukta Deobagkar retweeted
Vaccine delivery in two doses, synchronized to germinal center dynamics and T cell priming, enhances humoral immunity @SciImmunology #Chakraborty #Irvine @sachinbhag
science.org/doi/10.1126/scii…
Mukta Deobagkar retweeted
Trained immunity-based vaccines for infections and allergic diseases @jacionline @Palomares_Lab
jacionline.org/article/S0091…
Mukta Deobagkar retweeted
I'm excited to share the final piece of my doctoral research published today wherein we demonstrate that a two-dose priming vaccine regimen amplifies humoral responses by synchronizing delivery with germinal center dynamics science.org/doi/10.1126/scii…
Mukta Deobagkar retweeted
Mechanistic framework of how antibodies can optimize protective immunity, regulating B cell response participation and duration in a way that can be harnessed for vaccine design @ImmunityCP @isaak_quast
cell.com/immunity/fulltext/S…
Mukta Deobagkar retweeted
Changes in transcript isoforms can alter the function of interferon stimulated genes in human B cells @CellGenomics
cell.com/cell-genomics/fullt…
Mukta Deobagkar retweeted
Preprint alert 🚨 . Another great collaboration with Aysegul Sapmaz and Paul Geurink in Leiden. This time we identified and characterised USP24 as a deISGylating enzyme with roles in IFN-I production and potential use as an antiviral target. #ubiquitomics
USP24 is an ISG15 cross-reactive deubiquitinasethat mediates IFN-I production by de-ISGylatingthe RNA helicase MOV10 biorxiv.org/cgi/content/shor… #biorxiv_biochem
Mukta Deobagkar retweeted
Intermediate stages and microenvironmental factors involved in the differentiation of germinal center B cells into plasma cells
biorxiv.org/content/10.1101/…
