Retired CSO, with a passion for #THR and deep knowledge of the field. Opinions continue to be my own.
Switzerland
Joined November 2014
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Manuel Peitsch retweeted
Fascinating new preprint on bioRxiv tackles a whale of a question:
Whales are huge. So why don’t they get a ton of cancers?
biorxiv.org/content/10.1101/…
Manuel Peitsch retweeted
Nicotine exposure combined with the exposure to acrylonitrile (CYMA), a specific cigarette combustion marker, gives a good indication of the source of that nicotine. Nicotine with CYMA in smokers and dual users; nicotine without CYMA in « pure » e-cig, HTP, Snus or pouch users.
Manuel Peitsch retweeted
Prohibiting 'flavored' vapes may turn some teen vapers into good little angels. Yes. The rest will just switch to tobacco flavored vapes, or to smoking cigarettes or cannabis. So the net impact on public health is likely to be negative.
Manuel Peitsch retweeted
If I were @TEDTalks, I would be extremely embarrassed to have my name associated with this.
Yes, flagging was appropriate (it violates 3 out of 4 of the TEDx Content Guidelines), but it really doesn't go far enough.
A thread
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youtube.com/watch?v=Jm5TzMZy…
Manuel Peitsch retweeted
This clip is wildly irresponsible, @TEDx, as you seem to sense. Aside from Tomor's ulterior agenda and outright deceit, even FDA warns that misinformation like this about vaping has the perverse effect of deterring people from quitting cigarettes. We urge you to remove it.
A week ago, I retired from PMI after 15yrs dedicated to the science of #THR. It’s a consequence of age, not waning passion.
Looking forward to continue supporting the objective of making cigarettes obsolete.
1/2. Switching to non-combustible alternatives to cigarettes leads to improvements in xenobiotic metabolism. Positive implications for drug dosing: sciencedirect.com/science/ar….
2/2. See also: pubmed.ncbi.nlm.nih.gov/3320… and references therein, showing outstanding animal to human translation; in vitro study: pubmed.ncbi.nlm.nih.gov/3484….
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Manuel Peitsch retweeted
A big day in human genomics.
It took 21 years after first sequencing of the human genome to get the complete version science.org/doi/10.1126/scie… @ScienceMagazine
Manuel Peitsch retweeted
Our paper on T cell responses to Omicron has now been peer reviewed and is published in @Nature ! 🎉🎉🎉
nature.com/articles/s41586-0…
Manuel Peitsch retweeted
How to reduce your chance of dying from Covid by 99%?
Get vaccinated and a booster.
One of the most impressive graphs I've seen for the impact of vaccination in the US pandemic
(thanks @redouad @OurWorldinData for re-plotting my makeshift graph from earlier today)
1/2. New study by @PMIScience: Impact of aerosols on liver xenobiotic metabolism: A comparison of two methods of exposure pubmed.ncbi.nlm.nih.gov/3484…. Importantly, this study also further confirms that THS has reduced effect on liver metabolism compared to cigarette smoke.
2/2. Use of human liver spheroids in vitro confirms the Cyp1A2 results of 4 clinical reduced exposure studies, as well as in vivo animal data: pubmed.ncbi.nlm.nih.gov/3320…. Importantly, the effects of switching to THS were similar to those seen after smoking cessation.
A recent case study (with ENDS) that is relevant to this thread:
Fluctuation between cigarette smoking and use of electronic nicotine delivery systems: Impact on clozapine concentrations and clinical effect ncbi.nlm.nih.gov/pmc/article…
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Manuel Peitsch retweeted
The @FT made the graphic I've always wanted to see. This, I think, needs to be spread far and wide to help explain breakthrough infections and the usefulness of imperfect vaccines.
1/4. New article by my team showing, in vitro, that cigarette smoke (CS) accelerates aging in young human aortic smooth muscle cells and exacerbates the aging effect in old cells. This is consistent with the contributions of CS to CVD. pubmed.ncbi.nlm.nih.gov/3431…
3/4. However approx. 10-fold higher concentration of THS aerosol are needed to induce effects similar to those of CS. Importantly, this is again coherent with the reduced emissions of toxicants by THS relative of cigarettes (e.g. PMID: 27720919).
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