Max Curnin

SITUATION DETECTED: OpenAI President Greg Brockman says he thinks AI will make “significant strides” in biology, health, and curing diseases over the next 12–18 months, and that “death becoming a choice” could become possible.

Excited to welcome Matt Watson (@BioAndBaseball) to Pilgrim to help lead our policy efforts! Matt has spent more than 15 years working across biosecurity, pandemic preparedness, and national security. During COVID-19, he served as a senior advisor at @HHSGov, leading the development of the tools used to track hospital capacity nationwide and identify where the healthcare system was under strain. At the Center for Health Security, he worked alongside Dr. D.A. Henderson, who led the global campaign that eradicated smallpox. He also directed Johns Hopkins’ Emerging Leaders in Biosecurity (ELBI) program, whose fellows have held leadership roles at the White House, DHS, CDC, In-Q-Tel, Anthropic, and OpenAI. We’re thrilled to have Matt on board as we build the nation’s biodefense infrastructure! 🇺🇸

Neurophos has done and continues to do profound photonic engineering, using only standard foundry processes. This is merely one example, but happens to be the most fundamental one.

SITUATIONAL AWARENESS SEEKS TO RAISE MONEY TO BET ON FLUIDSTACK FUNDING ROUND WOULD VALUE NEOCLOUD FLUIDSTACK AT $40 BILLION

Boom! $100m Series A to bring ultrafast inference for open source. We believe the demand for ultrafast inference will be many times larger than slow inference. But right now it's never made it to market at scale. We are here to change it. First racks live in Q1 2027 🚀 Massive thank you to @jamespalmer13 at @BlackbirdVC and @dkwon98 at @abstractvc for co-leading. + participation from @QEDInvestors, @645ventures, @carbideventures, @endeavor_global and @ausgulfcapital, @icehouse_ventures and bold capital partners. Final hat tip to our entire cap table who doubled down. No better feeling as a founder than getting this level of conviction from your existing backers. @maxkilberg, @adwane and @bencasnocha from @villageglobal (pre-seed) @camborumand from @Fuse_vc (seed) @jthassel from evercrest (Seed) @morganschwanke from @manaventures (pre seed) @salil from Uncorrelated Ventures (seed) @themichaelljgo from @plugandplaytc (angel / pre seed) Spicy chips are going mainstream 🌶️ xitter.gq/general_compute/status…

I am shocked, absolutely shocked, that Anthropic ARR has likely gone vertical in October after they cut token prices. Except the exact same thing happened for the entire AI market, which is why GPU rental prices have surged while token prices declined. $100b plus in year-end ARR looks possible again.

Agentic demand is growing faster than I’ve ever seen anything grow

🚨 Everyone is watching the wrong bubble. And missing the greatest opportunity in 40 years because of it. While the crowd argues about AI and crypto, the real story is the asset sitting in every "safe" portfolio on earth. Bonds. The 1981 top printed 14% yields. The 2020 bottom printed 0%. That was 39 years of falling rates, and it ended in a single Covid panic. Covid was the turn. Rates hit zero, the system flooded itself with liquidity, and the 40-year bull in bonds quietly ended in the very moment everyone felt rescued. That's reflexivity in the Soros sense. For four decades, falling yields lifted every asset, which convinced everyone yields would keep falling, which lifted assets again. Belief and reality reinforced each other all the way down to zero. Then the loop turned. And here's the part almost no one has grasped: a turn this big isn't the end of the game. It's the start of a far better one. Here's why I'm genuinely excited. For 40 years, falling rates lifted everything together. Correlations converged. The tide carried every boat, so owning the whole ocean beat knowing which boat was seaworthy. Index beat judgment. Skill was a rounding error. That era is over, and what replaces it is the best environment for active investing in two generations. When the secular tide reverses, dispersion comes roaring back. Winners and losers split apart violently. Suddenly the things that were invisible for 40 years, valuation, balance-sheet quality, real cash flow, pricing power, decide everything. The gap between the great business and the mediocre one stops being a footnote and becomes the whole return. This is the world that made Buffett, Lynch, and Templeton. It's the world before 1981, where picking actually paid. It's coming back. And it arrives at the most lopsided starting line imaginable, which is exactly what makes the opportunity so rich. Concentration at a record. A handful of names carrying the entire index. Record IPOs listing at peak valuations and getting forced straight into peak index weights through mechanical, price-insensitive buying. The passive bid that everyone treats as ballast has become the marginal price-setter at the worst possible altitude. JPMorgan's own Guide to the Markets makes the setup clear. Map starting valuation against subsequent ten-year returns, and today's level points to roughly zero percent per year from the S&P over the coming decade. Sit with that. Zero from the broad index for ten years. Now flip it over. If the average is zero, the spread around that average is enormous. Some things compound beautifully. Others go nowhere or worse. A flat index for a decade isn't a dead market. It's the richest hunting ground for active investors in living memory, because the distance between right and wrong has never paid more. The whole architecture of modern investing was engineered for the era that just ended. - Buy stocks and chill. Built on a discount rate going one direction. Down. - The 60/40. Built on bonds rallying whenever equities fell. - Just buy the ETF. Built on a 40-year tailwind no one managing money today has ever seen reverse. That's the trap. And the mirror image of every trap is an opening for the people who see it first. Strauss and Howe gave this moment a name. The Fourth Turning. The last of the four cycles, the Crisis, when the institutions built for the old era meet the conditions of the new one. These turns feel like danger to everyone clinging to the last playbook. They are the launchpad for everyone holding the next one. The tide is turning. The old map is worthless. And the greatest opportunity of our generation is hiding in plain sight, inside the thing everyone still calls safe.