The Naef Lab (@NaefLab) header
The Naef Lab (@NaefLab) profile picture

Lab of computational and systems biology @EPFL_en. Interested in #circadian rhythm, #GeneRegulation, oscillators, single cells, transcription, theory, and more!

Lausanne, Switzerland
Joined November 2013
Photo by The Naef Lab (@NaefLab)Photo by The Naef Lab (@NaefLab)Photo by The Naef Lab (@NaefLab)Photo by The Naef Lab (@NaefLab)Photo by The Naef Lab (@NaefLab)Photo by The Naef Lab (@NaefLab)Photo by The Naef Lab (@NaefLab)Photo by The Naef Lab (@NaefLab)Photo by The Naef Lab (@NaefLab)Photo by The Naef Lab (@NaefLab)
🚨 Two new preprints on BioRxiv! 🚨 We’re excited to share two complementary studies built on a shared dataset, exploring how cells regulate translation elongation under amino acid starvation, from computational and biological angles. 🧠 + 🧬 = 🔬💥 Read on 👇
2
1
1
218
VeloCycle, developed by the team of @GioeleLaManno and @NaefLab is a manifold-constrained RNA velocity framework for uncovering cell cycle dynamics. nature.com/articles/s41592-0…
20
1
93
12,719
The Naef Lab retweeted
✨ We are proud to announce the winners of the best poster prizes at the recent EMBO | EMBL Symposium 'Biological oscillators' 🙌 A round of applause goes to: 🏅 Yasmine el Azhar, Hubrecht Institute, The Netherlands 🏅 Dinesh Jadhav, Department of Biology, Ashoka University, India 🏅 Julian Pietsch, Max Planck Institute for Terrestrial Microbiology, Germany 🏅 Elena Tonin, EPFL, Switzerland Take a moment to explore their outstanding contributions ➡️ s.embl.org/posterprizeEES24-… #EESBioOsc
1
2
9
2,912
🏅Congratulations to Elena Tonin for winning the @FEBS_Letters #PosterPrize at the EMBL Symposium on Organoids #EESOrgan at EMBL Heidelberg! 👏👏👏📷📷📷 @elena_tonin @NaefLab @EPFL #circadian_organoids
1
4
2
12
6,171
What happens to your body under circadian stress, eg shift work, and does everyone suffer the same? @Fitzgerald__lab show that females are more resilient than males at behavioural and molecular levels, which may involve interactions with the microbiome: science.org/doi/10.1126/scit…
8
2
26
3,322
The Naef Lab retweeted
Our researchers have shed light on how sex and age influence our body clocks, and how these rhythms play a role in sleep disorders, metabolic diseases and more. actu.epfl.ch/news/how-age-an…
1
3
1,772
The Naef Lab retweeted
➡️ Data indicate that chronic nighttime physical activity dramatically remodels daily rhythms of murine muscle gene expression, which in turn support daily fluctuations in exercise performance. 👇 sciencedirect.com/science/ar… @CircadianClocks @nick_krontiris @mitokondriac @Grimhood
12
32
I am delighted to announce that a draft of my latest book, “Probabilistic Machine Learning: Advanced Topics”, is now available online at probml.ai. It covers #DeepGenerativeModels, #BayesianInference, #Causality, #ReinforcementLearning, #DistributionShift, etc.
36
955
68
4,582
The Naef Lab retweeted
Next deadline to apply for a PhD project in Computational and Quantitative Biology is coming soon - April 15! Apply now to our program @epfl_edcb @EPFL_en with several fully funded positions: go.epfl.ch/edcb
Exciting preprint from @dana_peer lab on quantifying intestinal stem cell activity. Plus, interesting new deconvolution approach BayesPrism and pretty spatial visualization method SpaceFold. biorxiv.org/content/10.1101/…
4
48
4
202
🔴Point-counterpoint. Guiu and Jensen argue here that “In Vivo Studies Should Take Priority When Defining Mechanisms of Intestinal Crypt Morphogenesis”. cmghjournal.org/article/S235… And here is the rebuttal by Sugimoto and Sato. cmghjournal.org/article/S235…
4
22
4
92
Interested in single molecule imaging and omics analysis of mRNA translation? The @Naefelix lab has open positions for PhD students and post-docs! epfl.ch/labs/naef-lab/page-3… #AcademicJobs
This is the kind of data that students/post-docs are not enough aware of - but unfortunately crucial to plan their academic path
What happens to a paper submitted to a top journal? Among a set of manuscripts sent out for review by Cell in 2018: -33% were published in Cell -26% were published in another Cell-family journal -7% are still under review at Cell -The median time to publication was 391 days
A demo of the foot-step illusion (Anstis)
31
1,632
165
3,571
Our paper is finally out! Robust landscapes of ribosome dwell times and aminoacyl-tRNAs in response to nutrient stress in liver pnas.org/content/early/2020/…
This is the rejection letter for the work that just won the Nobel Prize. Don’t stop believing! I should save all of mine and maybe one day some stranger will think it’s an amazing relic and tweet it...
271
9,131
1,302
25,926
A new paper in @NaturePhysics from @Naefelix shows that the #circadian clock synchronizes with the cell cycle. Covered at nature.com/articles/s4156… #bioengineering
5
10