Lab of computational and systems biology @EPFL_en. Interested in #circadian rhythm, #GeneRegulation, oscillators, single cells, transcription, theory, and more!
Lausanne, Switzerland
Joined November 2013
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How do our internal 24h #rhythms change across sex and age? @lollotala and @TebogCirdec’s paper is now out in @ScienceMagazine. Congrats to everyone for this stimulating project!
science.org/doi/10.1126/scie…
#circadian #gtex #aging
The Naef Lab retweeted
🚨 Two new preprints on BioRxiv! 🚨 We’re excited to share two complementary studies built on a shared dataset, exploring how cells regulate translation elongation under amino acid starvation, from computational and biological angles. 🧠 + 🧬 = 🔬💥 Read on 👇
The Naef Lab retweeted
VeloCycle, developed by the team of @GioeleLaManno and @NaefLab is a manifold-constrained RNA velocity framework for uncovering cell cycle dynamics.
nature.com/articles/s41592-0…
Individuals with low hepatic VLDLR mRNA levels exhibit lipid deposition in the coronary artery and an increased incidence of heart attack. This breakthrough could have major implications for cardiovascular disease research.
Read more: nature.com/articles/s41467-0…
Thrilled to share that our latest research, led by @TomazMartini, has been published in Nature Communications! We discovered that VLDLR is highly expressed around hepatic central veins, particularly in female mice and premenopausal women compared to similarly aged males.
The Naef Lab retweeted
✨ We are proud to announce the winners of the best poster prizes at the recent EMBO | EMBL Symposium 'Biological oscillators' 🙌
A round of applause goes to:
🏅 Yasmine el Azhar, Hubrecht Institute, The Netherlands
🏅 Dinesh Jadhav, Department of Biology, Ashoka University, India
🏅 Julian Pietsch, Max Planck Institute for Terrestrial Microbiology, Germany
🏅 Elena Tonin, EPFL, Switzerland
Take a moment to explore their outstanding contributions ➡️ s.embl.org/posterprizeEES24-…
#EESBioOsc
🕰️ The 'Towards clinically actionable molecular biomarkers of the circadian clock' symposium in Venice has just kicked off. Looking forward to insightful discussions ahead! #CircadianResearch #WarwickInVenice
Together, our work provides new insights into the sexual dimorphism characterizing differences in VLDL kinetics and atherosclerotic cardiovascular disease. (5/5)
In humans, low hepatic #VLDLR expression correlates with a medical history of heart attack, and with atherosclerosis severity. (4/5)
We showed that the #VLDL receptor is restricted to the area around hepatic pericentral veins, with much higher mRNA and protein expression in female mice and women compared to male counterparts. (2/5)
Happy to share our latest preprint on a newly identified very low density #lipoprotein cycle in the #liver
biorxiv.org/content/10.1101/… (1/5)
Of interest to us: #syntheticbiology, #systemsbiology, #compbio, #cellular and #tissue engineering, #biomaterials, #functionalgenomics, #proteomics and #metabolomics. Encouraged topics: #cancerbiology, #infection, #immunology, #metabolism, #neuroscience, #neurorehabilitation.
Looking for a Tenure-track Professor position at @EPFL_en? Great opportunity, totally open topic in Life Science Engineering!
epfl.ch/about/working/profes…
Still one month to go: screening will start on Dec 15.
Looking for a Tenure-track Professor position at @EPFL_en? Great opportunity, totally open topic in Life Science Engineering!
epfl.ch/about/working/profes…
Still one month to go: screening will start on Dec 15.
OPPORTUNITY: we have an Assistant Professor opening at @EPFL_en in Life Science Engineering. Outstanding candidates across ALL areas of Life Sciences will be considered! Please circulate. Screening starting on Dec 15.
The Naef Lab retweeted
🏅Congratulations to Elena Tonin for winning the @FEBS_Letters #PosterPrize at the EMBL Symposium on Organoids #EESOrgan at EMBL Heidelberg! 👏👏👏📷📷📷
@elena_tonin @NaefLab @EPFL
#circadian_organoids
OPPORTUNITY: we have an Assistant Professor opening at @EPFL_en in Life Science Engineering. Outstanding candidates across ALL areas of Life Sciences will be considered! Please circulate. Screening starting on Dec 15.
Job opening! new Tenure Track Assistant Professor in Life Sciences Engineering.
ℹ️epfl.ch/about/working/profes…
#hiring #lifesciencesengineering #facultyposition
Congrats Nick & Tinh-Hai for very nice work! Happy it's out. Pretty impressive the Bayesian model that you implemented! I like the exact treatment of the continuous vs discrete ODE model (not so trivial...) Should be very useful for many case studies.
Very happy that our article "Uncovering personalized glucose responses and circadian rhythms from multiple wearable biosensors with Bayesian dynamical modeling" is now online in Cell Reports Methods! (doi.org/10.1016/j.crmeth.202…) A brief overview... (1/5)
Hey, got some excellent news about my promotion to full professor at @epfl. Many thanks for all the support and most importantly to my amazing @naeflab!
Congratulations to Nicolas Thomä @LabThoma and Felix Naef @NaefLab who have just been respectively appointed and promoted to new roles in SV! 👏 👏 👏
actu.epfl.ch/news/appointmen…
Excellent new paper by the @Fitzgerald__lab on sexual dimorphism in chronobiology, which is getting more and more interesting!
What happens to your body under circadian stress, eg shift work, and does everyone suffer the same? @Fitzgerald__lab show that females are more resilient than males at behavioural and molecular levels, which may involve interactions with the microbiome:
science.org/doi/10.1126/scit…
The Naef Lab retweeted
What happens to your body under circadian stress, eg shift work, and does everyone suffer the same? @Fitzgerald__lab show that females are more resilient than males at behavioural and molecular levels, which may involve interactions with the microbiome:
science.org/doi/10.1126/scit…