Developmental Biologist
Cyprus
Joined September 2018
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🎉🎉📖Our work on how intracellular calcium dynamics shape the mucociliary epithelium during Xenopus embryogenesis is now puplished @NatureComms . You can read the manuscript here: rdcu.be/ewTqQ . Many thanks to all the reviewers for their constructive input. 🐸🔬
Neophytos Christodoulou retweeted
We are searching candidates for two positions in the lab (@GurdonInstitute& @GeneticsCam,@Cambridge_Uni ): Research assistant (starting Sep 2026 shorturl.at/3wUvK) and Postdoc(shorturl.at/HuUXu). Please visit University's webs for details and apply. Please spread!
Neophytos Christodoulou retweeted
We are searching for an enthusiastic scientist to join our team and establish annual killifish as a model system for early developmental biology and biophysics! @embl
Apply here: embl.wd103.myworkdayjobs.com…...
Please re-post 🙏
Neophytos Christodoulou retweeted
Μελέτη του Παν. Κύπρου αναδεικνύει τον κρίσιμο ρόλο του ασβεστίου στην ανανέωση και ανάπτυξη ιστών dlvr.it/TMBgNk
Neophytos Christodoulou retweeted
Explant elongation initiates in the epithelium
A Research Highlight showcasing new work from @KatiaBarrett18, @ShalabhKAnand, Virginie Thome, Laurent Kodjabachian, Matthias Merkel, Pierre-François Lenne
journals.biologists.com/dev/…
ALT Fig. 2. Elongation behaviors of isolated and recombined explants in different conditions. (A) Table of isolation and recombined tissue experiments. Tissues are isolated with Activin or not and tested for elongation in isolation or recombined. This yields a total of eight conditions. (B-C′) Isolated mesenchyme and epithelial tissue experiments and their respective aspect ratio plots. N=5. (D-G′) Recombination experiments and their respective plots. Data are mean±s.d. N=5 for all conditions. Scale bars: 100 µm
Neophytos Christodoulou retweeted
Our paper is out!
We show how the extracellular matrix guides body axis formation in mouse—and possibly human—embryos during early pregnancy.
Grateful to @ZernickaGoetz @MZG_Lab for the chance to work with mouse, human, and stem cell–derived embryo models.
nature.com/articles/s41467-0…
New preprint🚨! Insertion of basal progenitors into an epithelium contributes to tissue morphogenesis and homeostasis. In this work, we study the role of intracellular calcium in multiciliated cell epithelial integration during Xenopus skin development. biorxiv.org/content/10.1101/…
Neophytos Christodoulou retweeted
Warmest congratulations & thanks to brilliant member of our team @Caltech Wenqi Hu, collaborator @Roser Vento (not on X) & HDBR for a fantastic journey in bringing this unique resource. We hope it will be valuable as a reference point to build more powerful stem cell models
Atlas of amnion development during the first trimester of human pregnancy @NatureCellBio @ZernickaGoetz
nature.com/articles/s41556-0…
Neophytos Christodoulou retweeted
Super excited that our paper is out. It describes a new mechanism for dealing with tissue crowding that does not involve cell extrusion.
nature.com/articles/s41467-0…
Neophytos Christodoulou retweeted
We have multiple open positions in #cellbio #devbio #singlecell #microbiome #genomics in the lab and posted it on The Node thenode.biologists.com/jobs/…
#xenopus #mouse #mucociliary
Neophytos Christodoulou retweeted
New publication by Henrike Berns, lab members and the Schmidts lab @Uniklinik_Fr out at Disease Models & Mechanisms.
journals.biologists.com/dmm/…
Congrats to Henrike and thanks to the Motivate program, @SFB1453_NephGen and @CIBSS for funding. 🐸 #xenopus #wnt #birthdefects #kidney
Neophytos Christodoulou retweeted
Check out our new paper in @nature nature.com/articles/s41586-0…. We report genetic mechanisms of neural tube defects in patients. Spina bifida is also known as meningomyelocele (MM). Prior family-based and association studies found few linked genes, so we took a different approach.
Neophytos Christodoulou retweeted
Very happy that my final PhD paper focussing on the maturation of the primitive into the visceral endoderm and its impact on embryo survival in mice is now published: sciencedirect.com/science/ar…
Huge thanks to my PhD supervisor & my collaborators for making this project possible
Neophytos Christodoulou retweeted
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New Preprint
Reptiles comprise ~23,000 species with an incredible range of diversity. The basis is laid during embryogenesis but severely understudied. We study the brown anole & describe its early embryogenesis for the first time:
biorxiv.org/content/10.1101/…
Neophytos Christodoulou retweeted
While we're at it: We are looking for 2 postdocs. One with experience in dev. Biol (pref. With mouse experience) and one with bioinformatics / modeling / multi-omics experience. Exceptional PhD candidates will be also considered for the project via IMPRS @mpi_ie recruitment.
✨️😀We are all thrilled to have been awarded an @ERC_Research #CoG grant to pursue our MAGIX project on #mucociliary #adaptations and #microbiomes in #xenopus 🐸. Thanks to the lab, reviewers and all supporters 😘
@CIBSS_UniFR @for5547 @SFB1453_NephGen
tinyurl.com/3f3tmhf8
Neophytos Christodoulou retweeted
Another preprint from the lab and a collaboration with Miriam Schmidts and her lab from @Uniklinik_Fr pediatrics. This work was carried out mostly by fantastic MD MOTIVATE student Henrike Berns. Funded by @dfg_public @CIBSS_UniFR and @SFB1453_NephGen.
biorxiv.org/content/10.1101/…
Neophytos Christodoulou retweeted
We all take for granted that we can just reprogram cells- iPSCs are ubiquitous. But DYK that this was first demonstrated in frogs? Talk about a #xensight! Sir John Gurdon showed that a differentiated intestinal nucleus can be reprogrammed when put into an enucleated egg- in 1962!
ALT Mama pigmented frog who donated the egg, with many progeny albino frogs generated from transplanting an albino intestinal nucleus into her egg. The progeny come out albino like the nucleus (clones) rather than like the mom.
Neophytos Christodoulou retweeted
Our latest #Ichthyosporean #EvoDevo story, led by M. Olivetta @ChandniBhickta @NChiaruttini & in co. with
@burnsajohn is finally out @Nature .
Link⏩: nature.com/articles/s41586-0…
Preprint⏩: biorxiv.org/content/10.1101/…
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Last, we show that intracellular calcium regulates multiciliated cell epithelial integration by regulating the stability of the apical actin network.More details in the manuscript.
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I would like to express my gratitude to Paris Skourides skourideslab.com (not in X) for his support throughout the years. In addition, I would like to thank @ResearchCy for funding this #basicresearch project!
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