Developmental biologist studying Ciona embryos. Postdoc in Levine lab. Princeton University Catalysis Initiative Fellow
Princeton, USA
Joined October 2021
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My latest paper, “An FGF Timer for Zygotic Genome Activation” is now published in Genes & Development.
genesdev.cshlp.org/content/e…
Nicholas Treen retweeted
What if you could deliver molecular tools directly into oocytes without microinjection? In our new paper, online today @Dev_journal (doi.org/10.1242/dev.202857), we introduce VitelloTag, a new cargo delivery tool to enable injection-free genome editing. 👇Read on for a short 🧵
Nicholas Treen retweeted
Chromatin scientists, want to reorganize genomic loci as you wish?
Out today in Cell--We made a tool that uses surface tension of engineered condensates to reposition DNA loci across microns of space in living cells in just a few minutes: VECTOR cell.com/cell/abstract/S0092…
Nicholas Treen retweeted
Kudos!👏 to Harsha Sen, 3rd-year grad student in @R_Mallarino lab, awarded Best Student Talk in Division of EvoDevo Bio at 2024 meeting of Society for Integrative and Comparative Biology #SICB2024. The talk: "Molecular evolution and development of the mammalian gliding membrane."
ALT Harsha Sen, third-year graduate student in the Mallarino lab, Department of Molecular Biology, Princeton University
Nicholas Treen retweeted
A clever strategy for multiplexed immunolabeling out today from Peng Yin's lab. "Thermal-plex" uses DNA probes that fluoresce sequentially when, and only when, activated with transient exposure to heating spikes at designated temperatures. nature.com/articles/s41592-0…
Nicholas Treen retweeted
New paper alert! Working with @CALM_STP @TheCrick @Princeton we have developed a method to stage zebrafish embryos using deep learning 💻📷 Many thanks to my co-authors David Barry and Matt Renshaw, as well as @veni_menon,@rburdine1 @glaevsky and Danelle Devenport 💙
Need to stage Zebrafish embryos? Don't want to do it manually? Try KimmelNet. @RebAnnJones @CALM_STP @TheCrick @Princeton
life-science-alliance.org/co…
Nicholas Treen retweeted
Very happy to have this research project from my postdoc with @EKfarley out in Dev Cell!
We wondered if single-nucleotide variants within heart enhancers can affect enhancer activity and phenotype.
Online now: Single-nucleotide variants within heart enhancers increase binding affinity and disrupt heart development dlvr.it/SxWzX8
Nicholas Treen retweeted
Delighted to share our new pre-print and introduce the mTurq2-Col4a1 mouse model in which collagen IV is endogenously tagged - thanks to all authors! A Window into Mammalian Basement Membrane Development: Insights from the mTurq2-Col4a1 Mouse Model biorxiv.org/content/10.1101/…
Nicholas Treen retweeted
Did you know? Zebrafish are more closely related to fish than to zebras. #ZebrafishFunFacts
Nicholas Treen retweeted
So excited to join the Dept of Biochemistry & Molecular Biophysics @ColumbiaBiochem and the Program for Mathematical Genomics!!! I am extremely grateful to Stavros and many others for the warm welcome, and greatly looking forward to learning, discussing & collaborating together.
Nicholas Treen retweeted
Delighted to share a short review article published in @ScienceAdvances!!
Enhancer dynamics: Unraveling the mechanism of transcriptional bursting.
science.org/doi/10.1126/scia…
Nicholas Treen retweeted
How do distal enhancers control transcription dynamics in living cells? Check out our latest work published in @MolecularCell!! We show that the dynamic assembly and disassembly of TF clusters at enhancers are a major source of transcriptional bursting. cell.com/molecular-cell/full…
Nicholas Treen retweeted
Levine lab reunion! It was great to see my former colleagues in Princeton, Nick @NicholasTreen João @J_Raimundo_ Laurence and Bomyi!!
My image was featured on the cover of the latest issue of Genes & Development!
You can read the paper here:
genesdev.cshlp.org/content/3…
Nicholas Treen retweeted
In this study, @NicholasTreen et al. describe a temporal transcriptional switch in the chordate embryo, regulated by FGF signaling. Read more about it here:
➡️genesdev.cshlp.org/content/e…
Nicholas Treen retweeted
Happy to announce publicly that I was awarded a K99/R00 from NCI! Big thanks to Proud Cliff Brangwynne @brangwynnelab and my co-mentor on this project Cigall Kadoch @CKadoch
Looking forward to big discoveries!
Nicholas Treen retweeted
Delighted to share our latest work published in @NatureComms! We show that non-coding enhancer transcription can flexibly modulate the efficiency of burst induction from linked gene either negatively or positively by changing the size of transcription hub. nature.com/articles/s41467-0…
This study shows how ERF is a key maternal repressor of zygotic genome activation as well as how signaling pathways can act as developmental timers in the early embryos.
Thanks to my co-authors @emilychavs @ClaireJoWeaver Cliff Brangwynne and Mike Levine.