How does the face form? Why do faces look different? We leverage the strengths of the zebrafish system to understand craniofacial development and variability.
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ALT Figure 3 (A) The smb mutant is epistatic to lof. Heterozygous smb adults were crossed to heterozygous lof adults and adult offspring were imaged with transmitted light. The dorsal fin and anal fin are indicated in the wild-type (wt) animal. An asterisk indicates an absent dorsal fin, a caret indicates elongated fins, and guillemets indicate an anal fin that is reduced in the AP axis but elongated in the proximodistal axis in smb;lof double heterozygous mutants (wt=8, smb=4, lof=8, smb;lof=5, expected=6.5 per genotype. Chi-square test; P=0.5641). (B) Nomarski images of fin induction and mesenchyme aggregation in wild type and smb heterozygotes at 5.8 mm SL (n=3 per genotype). Arrowhead indicates fin bud mesenchyme, asterisk marks absent fin bud.
