Supporting Preclinical Development of Nucleic Acid Therapeutics 🧬🧙🏻♂️
London, UK
Joined February 2022
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Version 4.0 is live! Fresh design, more customisation, professional HPLC traces, batch processing and generating ChemDraw structures from sequences
All now oligowizard.com !
Our database on approved nucleic acid therapeutics is online:
oligowizard.com/wiki/
Let us know what you think, and do get in touch if you’d like to contribute!
We are currently experiencing problems with the SSL certificate for oligowizard.com.
You can still reach the site via http rather than https.
We are looking into fixing this issue as quickly as possible - apologies for the inconvenience!
The chemical structure drawing tool is now publicly available - no sign-up required! Check it out at:
oligowizard.com/structures/
#oligotherapeutics #RNA #oligos
New FDA GUIDANCE on 'Nonclinical Safety Assessment of Oligonucleotide-Based Therapeutics':
fda.gov/regulatory-informati…
Prof Steve Dowdy wrapping up the delivery session. How do we tackle the 800 pound gorilla that is endosomal escape?
#OTS #OTS2024 #oligomeeting
Excited for the next gen session hosted by trainee representatives Eva-Maria Manz of ETH Zürich and Jathavan Asohan of McGill #OTS24 #oligomeeting #OTS
Oligowizard retweeted
THE DEADLINE FOR MENTORSHIP APPLICATIONS IS TODAY!
Mentor-mentee matches are completed by mid-August.
Don't miss this chance! Apply today!
oligotherapeutics.org/the-me…
#OTS #oligotherapeutics #oligonucleotides #science #research #mentorshipprogram #oligoresearchers #sciencecareer
Great paper!
But what happened to the pyrimidine N1 Nitrogen? 😉
Oligonucleotide therapeutics are emerging as a powerful platform for modulating gene expression across a range of diseases and applications.
A new #ScienceReview takes a look at recent advances that aim to transform oligonucleotide manufacturing. scim.ag/6DR
We’re celebrating our first mention in the scientific literature 🥳
Work by @alyssa_hill et al. in @ACS_Omega used oligowizard to calculate the properties of their (maleimide-modified) oligos!
Check out their paper below:
pubs.acs.org/doi/10.1021/acs…
Oligowizard retweeted
Very excited to present our work on oligo-conjugates towards the treatment of EPP @OTSociety #ots #ots23 #oligomeeting #oligotherapeutics
Here’s a teaser:
🧵
Great talk at @ETH by @DrMikeBooth on #oligonucleotides and how they can be turned into light-sensitive switches!
Oligowizard retweeted
It's #chemnobel season, so your reminder that DNA synthesis/Marvin Caruthers needs to win!
Without DNA synthesis there is NO *PCR*, *sequencing*, *cloning*, *CRISPR*, *siRNA*, *synthetic biology*, *mRNA vaccines*, *nucleic acid therapeutics*, *Nanotech*
What more am I missing?
As it's coming up to Nobel season, a reminder that Marvin Caruthers/DNA synthesis is way overdue the #chemnobel 🧬🏅
🚨 The development of this one piece of chemistry has made modern biology possible 🚨
