Durham, NC
Joined October 2013
- Tweets382
- Following258
- Followers373
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NE neuron diversity retweeted
A new review paper led by @mj_dahl, Agnieszka Kulesza and @WB_Markus. We review how deficient #dopaminergic and #noradrenergic modulation of hippocampal plasticity may contribute to memory loss in aging and Alzheimer's disease sciencedirect.com/science/ar… #locuscoeruleus
NE neuron diversity retweeted
We recently showed age-dependent alterations to locus coeruleus in the presence of tau pathology: sciencedirect.com/science/ar…
Want to know the molecular signatures that potentially drive these changes? Come chat with me during lunch at Poster 123 tomorrow July 18 at #AAIC2023!
NE neuron diversity retweeted
In this new preprint postdocs Meike van der Heijden & Amanda Brown set out to answer the question "why can cerebellar dysfunction present itself as different motor disorders?"
They find and optogenetically confirm different spike signatures for ataxia, dystonia, and tremor.
Neural spike signatures determine the behavioral presentation of cerebellar disease biorxiv.org/cgi/content/shor… #bioRxiv
NE neuron diversity retweeted
New pre-print led by @EmilyDPrevost identifying the Monosynaptic inputs to ventral tegmental area glutamate and GABA co-transmitting neurons biorxiv.org/content/10.1101/…
NE neuron diversity retweeted
It's that time of year! The Emory Neuroscience program is hold an open house on Wed November 2nd, 5-6pm EST. Come learn more about the application process and what life would look like as a grad student in Atlanta! RSVP here: forms.gle/qP8avsxS3reiSNpU7
NE neuron diversity retweeted
Finally OUT!!! very proud of this work led by Loic Broussot and @ContesseThomas Completely unexpected role of a LDTg GABA input to the VTA to promote fear freezing. Check out full article here (open access) and don’t skip the sup. video!
nature.com/articles/s41380-0…
NE neuron diversity retweeted
NEW PREPRINT FROM THE LAB📢📢: Locus Coeruleus firing patterns selectively modulate brain activity and dynamics! 3y in the making and this work is finally seeing light thanks to a fantastic teamwork! C Grimm, S Duss and @BohacekLab. Short thread ⬇️ biorxiv.org/content/10.1101/…
NE neuron diversity retweeted
The Neurotox Virtual Special Issue in ACS Chemical Neuroscience is out! Guest editor Heather Patisaul and I compiled work from experts in a range of fields to clarify mechanisms that underlie adverse impacts on the nervous system. @NCStateSciences 👇
pubs.acs.org/articlesonreque…
NE neuron diversity retweeted
Our recent work "A distinct astrocyte subtype in the aging mouse brain characterized by impaired protein homeostasis" made it to the Cover of @NatureAging August issue!
Volume 2 Issue 8, August 2022 - nature.com/nataging/volumes/…
NE neuron diversity retweeted
First published article from my lab!
It will be useful for labs using water restriction to motivate behavior.
eneuro.org/content/8/6/ENEUR…
NE neuron diversity retweeted
🔵Exciting new work from Sebastian Bouret's lab for all #LocusCoeruleus lovers: "Our data show that LC neurons dynamically track the amount of effort produced to face both cognitive and physical challenges with subsecond precision."
Also data on reward!🐵 journals.plos.org/plosbiolog…
NE neuron diversity retweeted
"Safer" chemical replacements for banned flame retardants may not be as safe as once thought. Research from @NCStateBioSci shows that they may pose a risk to brain development in children. Learn more: ncst.at/J7JP50GTxHL
NE neuron diversity retweeted
AAVs to express PPO for inhibiting synaptic projections in vivo are now available from Addgene. If anyone has any questions about using them for your terminals of interest, please reach out!
Plasmids from @mbruchas: A photoswitchable GPCR-based opsin for presynaptic silencing.
hubs.la/H0-jKZn0
ALT Schematic showing switching of the GPCR with UV light
NE neuron diversity retweeted
For anyone interested in reading about the super cool research I do in the lab of the brilliant Dr. Shannon Farris, give this a click and check it out!
(we're also looking for a new research assistant, link in article 🤓)
How do we recall faces, names, and where and when we met someone?
With a new @NIH R01, @sfarris721's lab is studying the bioenergetics, molecular cues, and distinct cell types that encode social memories in the brain’s hippocampus. #Neuroscience #Memory
vtx.vt.edu/articles/2021/11/…
NE neuron diversity retweeted
Tagging active neurons by soma-targeted Cal-Light biorxiv.org/cgi/content/shor… #biorxiv_neursci
NE neuron diversity retweeted
📢New publication from the lab! TL;DR: early mammalian germ cells are sensitive to low levels of environmental toxicants (in this case BPA). The cells may "look" normal but their molecular program is strongly affected with aberrant X-linked and retrotransposon desilencing. 👇
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NE neuron diversity retweeted
Publication Alert!!! Thanks to our wonderful collaborators @anewman2014, @SynapticSteph, @LCneuroscience, and many others for their contributions to this work, a true team effort! @RowanGSBS @BehavioralRowan sciencedirect.com/science/ar…
NE neuron diversity retweeted
Many years in the making. #dopamine Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo onlinelibrary.wiley.com/doi/…
NE neuron diversity retweeted
It’s out 🐭!
RGS14 modulates locomotor behavior and ERK signaling induced by environmental novelty and cocaine within discrete limbic structures | SpringerLink link.springer.com/article/10…
