@RFreireLab

Replicative Stress and Tumorigenesis Lab. Research Unit-Hospital Universitario de Canarias. Fond of photography.

 Tenerife-Spain
Joined November 2019
  • Tweets128
  • Following164
  • Followers294
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Raimundo Freire retweeted
Veronique Smits@VSmitsLabOct 13
Hoy he participado en una charla de divulgación científica de Chicas con Cienci@ULL en el IES Anaga 🧬🔬 ¡Gracias por la invitación y por acercar la ciencia a las nuevas generaciones! @CienciaULL
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Raimundo Freire retweeted
Román Gonzalez-Prieto@HombreRRoSep 23
Pre-print Alert! Spearheaded by @emilyshidalgo, RNF25 ubiquitin E3 activity modulates the three processes of the central dogma of Molecular Biology: DNA replication, Transcription and Translation by promoting the rapid degradation of different substrates biorxiv.org/content/10.64898…

RNF25 Ubiquitin E3 activity Safeguards Genome Integrity by Modulating DNA Replication, Transcript...

The human genome encodes several hundreds of ubiquitin E3 enzymes, most of which have poorly understood biological roles. In search for novel ubiquitin E3 enzymes involved in DNA damage tolerance, we...

biorxiv.org
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Raimundo Freire retweeted
Veronique Smits@VSmitsLabJul 20
Our collaboration with @RFreireLab on the #PID2025 project UPGRADE has been funded! 🎉 Many thanks to the reviewers and evaluation committee at @AgEInves for their support.
Agencia Estatal de Investigación@AgEInvesJul 16
Publicada Propuesta de Resolución Provisional de la convocatoria Proyectos Generación de Conocimiento #PID2025 para impulsar la #investigación, generación de #conocimiento y búsqueda de soluciones a los grandes desafíos de la sociedad. 🔗aei.gob.es/noticias/convocat…
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Raimundo Freire retweeted
Veronique Smits@VSmitsLabApr 20
Our latest publication by @Jessel_ap is out in @CellReports. We show that DNA damage in late mitosis triggers an ATM-dependent increase in RNF126 and BRAP, which promote cell survival under these conditions. With help from @RFreireLab. doi.org/10.1016/j.celrep.202…
Cell Reports@CellReportsApr 17
RNF126 and BRAP safeguard genome integrity after DNA damage in late mitosis dlvr.it/TS5VqX

RNF126 and BRAP safeguard genome integrity after DNA damage in late mitosis

Ayra-Plasencia et al. identify ATM-dependent upregulation of RNF126 and BRAP protein levels upon irradiation in late anaphase/telophase. These E3 ligases are required for the DNA damage response and...

cell.com
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Raimundo Freire retweeted
Cell Reports@CellReportsApr 17
RNF126 and BRAP safeguard genome integrity after DNA damage in late mitosis dlvr.it/TS5VqX

RNF126 and BRAP safeguard genome integrity after DNA damage in late mitosis

Ayra-Plasencia et al. identify ATM-dependent upregulation of RNF126 and BRAP protein levels upon irradiation in late anaphase/telophase. These E3 ligases are required for the DNA damage response and...

cell.com
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Raimundo Freire retweeted
Veronique Smits@VSmitsLabFeb 25
Fantastic seminar by Marcel van Vugt yesterday. And it was great to catch up. Thanks for stopping by! @ITB_ULL
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Raimundo Freire retweeted
Veronique Smits@VSmitsLab6 Nov 2025
It was a pleasure to host Miguel Blanco @DNA_Repair_USC in the lab today. Thanks for a great seminar Miguel!
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Raimundo Freire retweeted
Veronique Smits@VSmitsLab8 Nov 2025
Well done @CintiaFonRod on a great PhD defence! Thanks to the committee for their time and feedback. @DNA_Repair_USC @lblancodavila1 @DDRRepair Congratulations Dra. Fonseca Rodríguez! 🎓 🍾
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Raimundo Freire retweeted
Veronique Smits@VSmitsLab14 Mar 2025
Happy to share our latest publication by @YerayHdezReyes and @CintiaFonRod in @JMolBiol, highlighting two RNA helicases, DDX37 and DDX50, that ensure genome stability by preventing transcription-dependent R-loop formation. With help from @RFreireLab. doi.org/10.1016/j.jmb.2025.1…
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Raimundo Freire retweeted
Veronique Smits@VSmitsLab13 Dec 2024
Research Unit Christmas lunch🥂🎄🧑‍🎄🍕
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Raimundo Freire retweeted
Abraham Acevedo@Acevedo_lab4 Nov 2024
Job alert! Se ofrece contrato de doctorado asociado a proyecto (FPI) centrado en el estudio del papel central de TDP-43 en la ELA. Buscamos personas con entusiasmo y ganas de trabajar interesadas en el estudio de mecanismos moleculares de neurodegeneración en modelos de ratón
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Raimundo Freire retweeted
Abraham Acevedo@Acevedo_lab4 Nov 2024
Job alert 🚨 Fully funded PhD position associated with a project (FPI) focused on the study of the central role of TDP-43 in ALS. We are looking for enthusiastic people interested in the study of molecular mechanisms of neurodegeneration using innovative mouse models.
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Raimundo Freire retweeted
Abraham Acevedo@Acevedo_lab14 Aug 2024
🚨PhD position alert🕵️ We are looking for a motivated PhD candidate to join our laboratory in Tenerife, Spain, with a 4 year fully funded PhD contract (FPI) associated with a project focussing on understanding the role of TDP-43 in amyotrophic lateral sclerosis (ALS).
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Raimundo Freire retweeted
Veronique Smits@VSmitsLab22 Mar 2024
Congratulations Dr. Hernández Reyes for the successful PhD defense today! 🎉🍾 Thanks to the members of the committee @smotuit , @HombreRRo and @jonaygl for the discussion. Well done @YerayHdezReyes !! 👏
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Raimundo Freire retweeted
Cienci@ULL@CienciaULL9 Jan 2024
🧬 Esta semana estrenamos el 11º capítulo de la 4ª temporada de la serie divulgativa #ChicasconCienciaULL, cuya protagonista es la bióloga médica de la @ULL, Veronique Smits 🔔 ¡Activa la campana en YouTube! youtube.com/watch?v=5iKxxkDR… #FundaciónCepsa
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ONLINE NOW our story on the role of interferon/ISG15 in BRCA contexts! Congratulations to Ramona Moro, @uddipta_biswas, and all the co-authors! A great collaborative effort with Shyam Sharan, @RFreireLab and @Arnab_RC1. nature.com/articles/s41467-0… Thrilled to hear your feedback!

Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15

Nature Communications - Here the authors show that the basal activation of the interferon/ISG15 pathway is required for the stability of nascent DNA during replication and its upregulation promotes...

nature.com
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Raimundo Freire retweeted
Veronique Smits@VSmitsLab17 Jul 2023
Very happy that our joined project with @RFreireLab is among the funded projects! 🍾 🎉💪 Thanks for the support @AgEInves
Agencia Estatal de Investigación@AgEInves17 Jul 2023
‼️ La @AgEInves publica la Propuesta de Resolución Provisional de los Proyectos Generación de Conocimiento 2022 💰625 Millones € aei.gob.es/sites/default/fil… #FondosEuropeos #Ciencia
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Last day at which has been my second home during the last 6 years. From my MSc and PhD to my very first months as Postdoc, I’m really pleased with all it has meant both professionally and personally. Thanks, it’s just a see you soon! @RFreireLab @VSmitsLab
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Raimundo Freire retweeted
Veronique Smits@VSmitsLab30 Jun 2023
Ha sido un placer participar en el curso "Avances en Biología Molecular y su traslación a Biomedicina y Biotecnología" de la @UIMP. Gracias @lblancodavila1 y Miguel de Vega por la organización!
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Raimundo Freire retweeted
Marcus Smolka@MarcusSmolka1 Jun 2023
New preprint: TOPBP1 has a specialized role in XY silencing that can be separated from its many other meiotic and somatic roles. Major effort by Caroll Ascencao and @simsjr222. Great collaboration with @cohen_lab, Weiss, Grimson and @RFreireLab labs. biorxiv.org/content/10.1101/…

A TOPBP1 Allele Causing Male Infertility Uncouples XY Silencing Dynamics From Sex Body Formation

Meiotic sex chromosome inactivation (MSCI) is a critical feature of meiotic prophase I progression in males. While the ATR kinase and its activator TOPBP1 are key drivers of MSCI within the special...

biorxiv.org
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