023 // PHASE III π§ͺ RETATRUTIDE TRIAL PATIENT 332.8 β 259.6 β73.2 TRAINING β’ NUTRITION β’ BLOODWORK
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6 MONTHS AS A PHASE 3 RETATRUTIDE TRIAL PATIENT π§ͺ
SHOT DAY β SPECIAL EDITION
entry//027
April 7 β October 7
332.8 lbs β 268.8 lbs
64 lbs down.
19.2% of my starting body weight gone.
Class III severe obesity β Class I obesity.
Hereβs what the first 6 months looked like.
𧡠THREADπ
Whatβs your strategy when you hit a plateau on a GLP-1?
So you got stuck or hit a plateau on your GLP? Now what? Everyone recommends the same things (more weight training, more exercise, check your protein intake, add more carbs, better sleep, etc.). My wife got stuck for almost a month and a half on 5mg of Reta several weeks back. I kept asking her to consider EVERYTHING else (protein intake, carbs, exercise, weight training) before titrating again. It was hard on her because she wanted to see the scale keep moving (and I get it). We recently took a trip to Aruba where we ate decent, but certainly not as good as you eat from home, and only walked one night in 6 days. Apparently doing less helped (this was counterintuitive to what I thought). After we came back and got back on the same routine she smashed through the wall and has lost 6 more lbs in the last 3 weeks. The journey continues!
I read some of @PGC1a_RB old posts about glycine.
For the past two nights, Iβve taken 5 g before bed, and these are the results.
π¦ The best thing I did for my gut on a GLP was stop waiting for problems to show up.
What helped me:
β’ No alcohol
β’ No fried food
β’ Leafy greens + enough fibre
β’ Probiotics
β’ Lots of water
β’ Psyllium H if things start slowing down
β’ Walk after meals
Any tips Iβm missing that helped you?
Let me present the risk conversation a different way.
ποΈ NAION on GLP-1s: about 6.4 cases per 100,000 person-years in one FDA analysis.
Now look at obesity:
β’ Heart attack risk: roughly 2.4Γ higher
β’ Heart failure: 3.9Γ higher
β’ Ischemic stroke: 1.6Γ higher (PubMed)
Another large meta-analysis found obesity associated with about 81% higher coronary heart disease risk vs normal weight. (PubMed)
None of that means ignore GLP side effects.
It means risk needs context.
Obesity isnβt the risk-free option.
ποΈ NAION
Whoβs more at risk
β’ Age 50+
β’ Diabetes
β’ High BP/cholesterol
β’ Sleep apnea
β’ Smoking
β’ Previous NAION
Actual risk
Still very rare.
FDA analysis found about 6.4 cases per 100,000 person-years on GLP-1s vs 3.8 per 100,000 in comparators.
Roughly 0.006% per year in that analysis.
ποΈ NAION
Whoβs more at risk
β’ Age 50+
β’ Diabetes
β’ High BP/cholesterol
β’ Sleep apnea
β’ Smoking
β’ Previous NAION
Actual risk
Still very rare.
FDA analysis found about 6.4 cases per 100,000 person-years on GLP-1s vs 3.8 per 100,000 in comparators.
Roughly 0.006% per year in that analysis.
You have more of a chance going blind being a fat slob as you do taking these medications
Here is some context:
Before everyone panics about the GLP eye warning lets add some perspective
The eye condition they are talking about NAION is serious but it is rare
The FDA found about 6 cases per 100,000 people a year on a GLP versus about 4 on other meds
That is 3 to 4 extra cases per 100,000 a fraction of a percent
Now compare that to staying obese and potentially diabetic
Diabetic eye disease is one of the leading causes of blindness in adults and it does not hit a handful per 100,000 it hits whole percentages of people
In one study over 10 percent of diabetics developed vision threatening retinopathy
So yes know the risk it is real
But the thing actually wrecking peoples eyes at scale is the obesity and diabetes these drugs are built to fix
Perspective matters
You know what? This is my last shot of 9 mg.
π SHOT DAY β ENTRY//032
Phase 3 retatrutide trial participant
Next week Iβm back at the clinic and moving up to 12 mg.
I have zero problem moving up. Reta has treated me ridiculously well so far.
73.2 lbs down
22.0% of my starting weight gone
For perspective, TRIUMPH-1 averaged 19.0% at 4 mg, 25.9% at 9 mg and 28.3% at 12 mg, all at 80 weeks.
Iβm beginning week 32.
Looking forward to seeing what 12 mg feels like.
π₯ Early Reta/GLP suppression made protein way harder than it is now.
So I kept it simple:
β’ 2β3 Dannon Light + Fit / Oikos yogurts
β’ Fairlife chocolate protein milk
β’ Chicken/Pre-cooked chicken strips, easiest for me to get down
β’ Cottage cheese
β’ Tuna pouches
That alone can put you over 100g protein pretty easy.
Early suppression taught me one thing fast: make protein easy or youβll miss it.
π©Έ LOW BLOOD PRESSURE
RETA/GLP POTENTIAL SIDE EFFECT
Signs
β’ Dizziness when standing
β’ Lightheadedness
β’ Weakness
β’ Blurry/grey vision
β’ Feeling like you might pass out
β’ Fainting
What to do
β’ Sit or lie down
β’ Get up slowly
β’ Hydrate
β’ Make sure youβve eaten
β’ Check your BP if you can
β’ Persistent symptoms, fainting, chest pain or severe weakness β get medical help
How common?
Not one of the most common GLP side effects, but decreased blood pressure is a recognized risk and can become more likely with weight loss, dehydration or under-eating.
The aura oozing from this book is absolutely generational. Iβm literally shaking.
Took a quick glance (wife too) and there are a ton of recipes that we canβt wait to try!
@DigitalFringed1
If the Bills win tomorrow this is my new lucky sweater. Mostly because my other ones donβt fit anymore π
Patient 023 π retweeted
8 Things you need to know before starting your peptide journey
1. Get comfortable with injections. Most peptides are injected because of their bioavailability they can get destroyed before reaching the bloodstream.
2. Most peptides come from China, so testing is important to check purity levels, heavy metals, and other contaminants. The easier way to go about it is to buy from trusted vendors who have already made the process easier for you. You donβt need to start going to labs to test them. If you need a vendor, you can find one through my bio and get it delivered within 24 hours or choose anyone you feel safe with.
3. You might not see the name βRetaβ on some sites. You might see βGLP-3β or something like βRTβ because of regulatory controls.
4. Most peptides come in dry form, so youβll need to reconstitute them with BAC water or sterile water. Donβt mix them with a random water source.
5. Use an alcohol swab to clean the injection site before injecting.
6. Most peptides are injected subcutaneously, into the fatty tissue around your stomach, thighs, and other areas.
7. Get your blood work done.
8. Follow quality accounts people who share their personal views and give genuine feedback, not people who share things just because they were sent to them orjust for sales. There are many great accounts out there to follow like @peptidepirate @RetaDiary @fitcap @James9thLife @nocturnmachine @GMarieSnickers
π TRIAL BTS: my Reta pens
Besides all the testing, every 4 weeks I go to the clinic and pick up a new box.
β’ 4 single-dose pens
β’ 1 shot per week
β’ First one gets taken at the clinic
β’ Unlock it, inject, done
β’ Pen gets tossed after
Theyβre single-dose auto-injectors. No mixing, no reconstituting, no splitting doses.
Theyβre loud as hell when they fire π but I barely feel the actual injection.
Patient 023 π retweeted
Badger be here for long time Reta and no drinking helped badger loose 68 lbs but badger still have 70 to go badger is very big badger learn a lot from friends here on x badger has learning disability but he can drive and things badger just want to say thank u for helping him loose wait ty frinds it free to follow and learn badger thankful
@ElevateBiohack
@RetaDiary
@fitcapgirldad
@peptidepirate
@OSHOMAH01
@ThePepGuy
@brentlajeunesse
@Gabri3lTheGreat
@Satoshipeptides
π§ͺ 7 MONTHS AS A PHASE 3 RETATRUTIDE TRIAL PARTICIPANT
β’ Down 72 lbs
β’ Active every day
β’ Leaner
β’ Stronger
β’ Building muscle
β’ Mental health is the best itβs been in a long time
7 months ago I felt like my life was basically over.
Still got plenty of work to do, but I'm starting to feel unstoppable.
