@RyanKMuir

Postdoc in the Bogyo Lab at Stanford. Ph.D. from UCSF in the Renslo Lab. Chemistry and Chemical Biology

 San Francisco, CA
Joined February 2019
  • Tweets23
  • Following66
  • Followers81
Excited to share our recent publication on identifying & targeting ferrous iron addiction in KRAS-driven cancers using the TRX-based prodrug strategy. doi.org/10.1084/jem.20210739
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It was a pleasure working with @__mguerra__ on this review. I love this topic and am excited to see where the field is moving!
Matthew Bogyo@mbogyo14 Jan 2022
Our latest review on activity-based diagnostics is out at ACS Chem Bio! Check it out using this link which will allow you to download for free. Great work from @RyanKMuir and @__mguerra__ pubs.acs.org/articlesonreque…
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Thrilled to share that the Zaro Lab's first ever preprint is now LIVE on @ChemRxiv 🧪 We developed a new, highly-selective (like, *really* selective) covalent inhibitor of BTK through the simple elaboration of fumarate ester-based warheads (1/n): chemrxiv.org/engage/chemrxiv…

Improved Electrophile Design for Exquisite Covalent Molecule Selectivity | ChemRxiv

Covalent inhibitors continue to show therapeutic promise. However, off-target reactivity challenges the field. Extensive efforts have been exerted to solve this issue by varying the reactivity...

chemrxiv.org
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Thanks to @LewisLabMSKCC for highlighting our work presented at @WMISWMIC developing nuclear imaging methods to better exploit the labile iron pool for cancer therapy @adamrenslo @UCSFimaging @RyanKMuir @nzhao2ucsf
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Ryan Muir retweeted
SNMMI@SNM_MI23 Jul 2021
A new radiotracer that detects iron in cancer cells has proven effective, opening the door for the advancement of iron-targeted therapies for cancer patients, according to research published in @JournalofNucMed. ow.ly/Tfhg50FCgq1 #PrecisionMedicine #Theranostics #Cancer
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As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through phospholipidosis are unlikely to be effective in vivo. Screening out such drugs may allow a focus on drugs with better clinical potential. fcld.ly/xzcdmd9
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To photo-affinity, and enzyme/AA-reactive ABPs, you can add ABPs activated by intracellular labile iron. Congrats to Ying-Chu, Juan and collaborators @aPOPEtosis and @SJD956! #ferroptosis @J_A_C_S pubs.acs.org/doi/10.1021/jac…

Reactivity-Based Probe of the Iron(II)-Dependent Interactome Identifies New Cellular Modulators of...

Abstract. Ferroptosis is an iron-dependent form of cell death resulting from loss or inhibition of cellular machinery that protects from the accumulation o

pubs.acs.org
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We are deeply sorry for the opinions expressed in the recent piece published in our journal. We recognize the responsibility we have to our community and are conducting an internal investigation into this incident. Read our full statement here: ow.ly/XYht50A0sAF
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I am very disturbed and disappointed by Prof. Hudlickly's comments in this article in @angew_chem where he makes the case that “diversity of the workforce” has a ”negative impact” on the field of organic synthesis (see the ridiculous figure!) onlinelibrary.wiley.com/doi/…
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Figure 1 says that "diversity in the workforce" is having a negative impact on the field of Organic Synthesis. Additionally complains that grad students are no longer willing to "submit to their mentors." I can't believe @angew_chem published this. drive.google.com/file/d/1Dy8…
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Exploiting KRAS-driven Ferroaddiction in Cancer Through Ferrous Iron-Activatable Drug Conjugates (FeADC) biorxiv.org/cgi/content/shor… #bioRxiv
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The findings of a Nature paper suggest that there may be potential for developing treatments for #COVID19 by repurposing drugs that are already approved or under investigation for other conditions. go.nature.com/3d4DHmy
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Our collaboration with @QBI_UCSF on #SARS_COV_2 host factors and how to drug them is online now biorxiv.org/content/10.1101/… thanks to everyone. #COVIDー19 @UCSF @UCBerkeley @HHMINEWS
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If you speak a language other than English and want to help me translate this, there's a form here docs.google.com/forms/d/e/1F… thank you thank you thank you
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Sneaking antibiotics into bacteria with siderophore-iron(III) conjugates is a cool trick. In our latest paper in @ACS_Infectious we instead uncage antibiotics via reaction with free iron(II) at infection sites buff.ly/2Xh7m85 @EricSkaar @RyanKMuir @erin_r_green
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Replying to @NHL
@NHL Bad look saying you'll show the Stanley Cup at the Giants game from the 5th inning on and no-showing, leaving hundreds of fans waiting...
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@NHL A lot of upset fans, especially when we're told it didn't show up because the people handling the Cup were too busy partying
UCSF laboratories of @adamrenslo and @mikeevans_ucsf describe a small molecule PET reagent for imaging the disposition of labile ferrous iron in animals. @UCSF @UCSFimaging @ucsfpharmacy pubs.acs.org/doi/full/10.102…
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Take a look at my 3 minute Grad Slam talk that I gave a couple of weeks ago! Turns out the hardest part of grad school is summing up 5 years of research in only 3 minutes... #GradSlam m.youtube.com/watch?v=XzCL0h…
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Warmest congratulations to David Wu, winner of this year's #UCSF #GradSlam, for his talk on a blood test to detect concussion. Also, kudos to runner-up Olivia Creasey, and 3rd place/People's Choice winner Ryan Muir, and ALL the Slam finalists. You guys were fantastic!
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