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Ryan Knight

@RyanKnight_

Doctoral Student - Wellcome-Wolfson Institute for Experimental Medicine. Inflammasome Biology & Innate Immunity (views own)

 Belfast, Northern Ireland
linkedin.com/in/knight-ryan
Joined July 2021
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  • Followers36
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Photo by Ryan Knight (@RyanKnight_)Photo by Ryan Knight (@RyanKnight_)
I'm super proud that our work using iPSC-derived macrophages as a model for human inflammasome signalling is now online in @CellRepMethods @ChloeMck2022 These are a great cell model for studying therapeutically relevant inflammatory pathways! shorturl.at/50ss3
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TRIFosomes found😀. Very proud of our team’s work to identify endogenous TRIFosome. Surprisingly whilst TRIFosomes activate NFKB, IFN signaling is from monomeric or dimeric TRIF. doi.org/10.1126/sciadv.aeb95…
Toll-like receptor signaling outcome is determined by the stoichiometry of the endogenous TRIFosome

Toll-like receptor signaling outcome is determined by the stoichiometry of the endogenous TRIFosome

A previously entirely unknown mode of TLR signal transduction is elucidated.

science.org
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RESEARCH BREAKTHROUGH: Discovery could lead to new drug treatments for #InflammatoryDiseases including #Alzheimers, #asthma, #arthritis and #obesity. Find out more: ow.ly/aYb050WQeJo #LoveQUBResearch @WWIEM_QUB @bioagelabs @MHLSQUB
Image shows a square box -the top shows a researcher filling a pipette. The bottom contains a red rectangle with white text that reads: “This research breakthrough highlights the benefit of combining academic expertise with industry to make real-world impact. We hope this discovery will lead to the development of new, targeted anti-inflammatory drugs which will help treat these devastating diseases.” Dr Rebecca Coll, Senior Lecturer in Immunobiology. There is also a photo of Dr Rebecca Coll beside the text in the bottom left-hand corner.

ALT Image shows a square box -the top shows a researcher filling a pipette. The bottom contains a red rectangle with white text that reads: “This research breakthrough highlights the benefit of combining academic expertise with industry to make real-world impact. We hope this discovery will lead to the development of new, targeted anti-inflammatory drugs which will help treat these devastating diseases.” Dr Rebecca Coll, Senior Lecturer in Immunobiology. There is also a photo of Dr Rebecca Coll beside the text in the bottom left-hand corner.

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Had a brilliant couple of days with the lab in Galway at the @Irishimmunology meeting - great science and great craic !!!
Image from Dr Rebecca Coll (@Rebecca_Coll)
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Huge congratulations to the new Dr Mawhinney!! @TheaMawhinney Thank you to her fantastic examiners Prof Suzanne Cloonan @suzcloo and Prof Cliff Taggart @WWIEM_QUB
Image from Dr Rebecca Coll (@Rebecca_Coll)
Image from Dr Rebecca Coll (@Rebecca_Coll)
Image from Dr Rebecca Coll (@Rebecca_Coll)
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What a brilliant week for the lab in Munich! So much inflammasome research and beer 🍻 #EMBOinflammasomes2024 @TheaMawhinney @Emck197 @ChloeMck2022 @RyanKnight_
Image from Dr Rebecca Coll (@Rebecca_Coll)
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Still a few days left to apply for our Posdoct position! Exciting project (biased opinion), lovely historic city , fantastic uni and great people. Come join our team! Contact us if you have questions!
Dave Boucher (@dave_boucher) profile pictureDave Boucher@dave_boucher29 Jul 2024
Interested in Caspase and LPS signalling? Looking for a multidisciplinary position with a bit of immunology, biochemistry and host-pathogen interactions? Look no further! Our lab is recruiting a second PDRA funded by @BBSRC. See details below
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I’m simply horrified to see @NHSEngland now literally breaking the law in how it misrepresents physician associates & other allied health professional - who are NOT doctors - to the public. These posters are from the Bradford District & Craven Health & Care Partnership. 1/n
Image from Dr Rachel Clarke (@doctor_oxford)
Image from Dr Rachel Clarke (@doctor_oxford)
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Welcome to the world of Immunology 🧑‍⚕️Combining biology and medicine, our immunologists work to treat disease and disorders affecting immune systems 🧬 The #Balmoral2024 guests are fascinated!
Image from QUB Strategic Engagement (@QUBEngagement)
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The UK is back in this scheme! If you're interested in innate immunity, temperature, or inflammasome signalling in human disease - please get in touch about applying together. Belfast and @WWIEM_QUB are great places to live and work!
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The first of two new @biorxivpreprint #preprints from @IIIBonn AG Latz postdoc Matt Mangan. #1 investigates the role of SCFAs in #NLRP3 inflammasome activation, showing that butyrate + TLR activation triggers IL-1B release from human macrophages. biorxiv.org/content/10.1101/…
Butyrate and propionate are microbial danger signals that activate the NLRP3-inflammasome in human...

Butyrate and propionate are microbial danger signals that activate the NLRP3-inflammasome in human...

Short chain fatty acids (SCFAs) are immunomodulatory compounds produced by the microbiome through fermentation of dietary fibre. Although they are generally considered beneficial for gut health,...

biorxiv.org
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Becoming a new PI is hard but is made 100% easier when you're surrounded by wonderful colleges. Never walk alone. My amazing colleague @dave_boucher and I just published our first work together ❤️ #inflammasomes #epithelial innate immunity @YBRI_UoY febs.onlinelibrary.wiley.com…
FEBS Press

FEBS Press

Strategically placed, our epithelium plays an essential role in maintaining and guarding tissue homeostasis. One key set of defense mechanisms is represented by our inflammasomes, which sense and...

febs.onlinelibrary.wiley.com
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Want to study skin immunity with a rising star of skin immunology and a world-leader in acne (and me :) )? Check out this great PhD opportunity in beautiful York!
Kim Samirah ROBINSON (@KimSamirah) profile pictureKim Samirah ROBINSON@KimSamirah9 Mar 2024
Love the skin your in? Want to learn more about skin innate immunity? I have a fully funded PhD position investigating acne and inflammasomes. Link below. Get in contact with any questions. Please RT! findaphd.com/phds/project/un… With amazing @dave_boucher and prof Alison Layton
Understanding the interplay between acne treatment and the inflammasome at University of York on...

Understanding the interplay between acne treatment and the inflammasome at University of York on...

PhD Project - Understanding the interplay between acne treatment and the inflammasome at University of York, listed on FindAPhD.com

findaphd.com
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Looking for a great opportunity to further your research career? Don't miss out on this Postdoctoral position at Coll Lab, Queen's University Belfast! Check it out here wix.to/7QGXWDn #STEMCareers #ResearchJobs #AcademicOpportunities #Immunology @y_efis @yISI_ie
Image from Irish Immunology (@Irishimmunology)
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We are looking for a postdoc to join our team @WWIEM_QUB - this is a 3 year MRC funded position to investigate ferritin and inflammasome activation in ARDS in collaboration with @ceciliaokane and @dfmcauley Please apply at shorturl.at/jvPRW DM me for more info! Please RT!
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Looking for a paid summer studentship? Check out @GemmaBanister exciting project. Gemma secured the studentship herself (Bravo!) and will be a great mentor for a young scientist!
Gemma Banister (@GemmaBanister) profile pictureGemma Banister@GemmaBanister1 Feb 2024
📢FUNDED UNDERGRADUATE SUMMER STUDENTSHIP! The application for Generation Research summer studentships is open! I will be hosting a student who will work on two key proteins in the immune response to bacteria🦠! Take a look here tinyurl.com/GenRes-summer-st… @BBSRCWhiteRose
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Big congratulations to @JaredCoombs_ @DrAlinaZ @CarolineLHolley and whole @inflammasomelab team and our overseas collaborators @dave_boucher @Rebecca_Coll and Mathias Chamaillard‘s team! @IMBatUQ
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Innate Immune sensing in Immunology @abcam kicking off with the amazing @ClareBryant13 ! Exciting day ahead
Image from Dave Boucher (@dave_boucher)
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🍾 to celebrate recent grant success with the lab! Our MRC project will examine the role of ferritin and inflammasome signalling in ARDS. Huge thanks to co-applicants @dfmcauley +Cecelia O'Kane! Anyone interested in a postdoc with us please get in touch! Job ad to follow soon😀
Image from Dr Rebecca Coll (@Rebecca_Coll)
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Had the great pleasure of presenting at the GREMI meeting at the Pasteur yesterday. It was a super interesting day of #inflammation research - thank you to our hosts!
Image from Dr Rebecca Coll (@Rebecca_Coll)
Image from Dr Rebecca Coll (@Rebecca_Coll)
Xavier Norel (@boDDDLV) profile pictureXavier Norel@boDDDLV22 May 2023
GREMI: The French Society of Inflammation organizes its One-Day GREMI meeting: “Cells & Inflammation: Live and Let Die!”, November 10th, 2023 at Pasteur Institute - Paris, France lnkd.in/efqEFmbX
GREMI: The French Society of Inflammation organizes its One-Day GREMI meeting: “Cells & Inflammat...

GREMI: The French Society of Inflammation organizes its One-Day GREMI meeting: “Cells & Inflammat...

GREMI: The French Society of Inflammation organizes its One-Day GREMI meeting: “Cells & Inflammation: Live and Let Die!”, November 10th, 2023 at Pasteur Institute - Paris, France

linkedin.com
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