@ScienceTM

Science Translational Medicine is the leading weekly online journal publishing translational research at the intersection of science, engineering and medicine.

 Washington, DC
science.org/journal/stm
Joined February 2011
  • Tweets4K
  • Following269
  • Followers35.2K
2.7KMedia
Science Translational Medicine retweeted
Eric Topol
@EricTopolSep 9
An unanticipated connect between the risk of heart disease (assessed by genomics) and features of the spleen (assessed by AI); a new heart-spleen axis uncovered @ScienceTM @pnatarajanmd science.org/doi/10.1126/scit…
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Pradeep Natarajan
@pnatarajanmdSep 9
Our study led by M. Kamineni & with @ZhiYu_ACGT uses imaging and genomics to prioritize a role for the spleen in coronary artery disease science.org/doi/10.1126/scit… @ScienceTM
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Science Translational Medicine retweeted
Ahmed Alaa@_ahmedmalaaSep 9
New work in @ScienceTM by Meghana Kamineni and a great team led by @ZhiYu_ACGT and @pnatarajanmd! We used deep learning-extracted features from imaging and genomics to understand the role of spleen in coronary artery disease.
Pradeep Natarajan
@pnatarajanmdSep 9
Our study led by M. Kamineni & with @ZhiYu_ACGT uses imaging and genomics to prioritize a role for the spleen in coronary artery disease science.org/doi/10.1126/scit… @ScienceTM
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Science Translational Medicine retweeted
Naveed Tavakol, PhD@naveedtavakolAug 20
It's been a long time coming....! Check out our new study out in @ScienceTM on modeling breast cancer metastasis and organ-specific remodeling using engineered human tissue models! science.org/doi/10.1126/scit… @theNCI @AmericanCancer @stemcellpodcast

Organ-specific colonization and niche remodeling in a human tissue model of metastasis

A configurable bioengineered multitissue platform with vascular circulation enables investigation of human breast cancer metastasis.

science.org
Gordana Vunjak-Novakovic@GVNlabAug 20
Check out our new study, out today in @ScienceTM on "Organ-specific colonization and niche remodeling in a human tissue model of metastasis." Congrats to the whole team and thanks to our funding sources!! Article: science.org/doi/10.1126/scit… Press release: engineering.columbia.edu/abo…
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Science Translational Medicine retweeted
Gordana Vunjak-Novakovic@GVNlabAug 20
Check out our new study, out today in @ScienceTM on "Organ-specific colonization and niche remodeling in a human tissue model of metastasis." Congrats to the whole team and thanks to our funding sources!! Article: science.org/doi/10.1126/scit… Press release: engineering.columbia.edu/abo…
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ONLINE NOW in @ScienceTM from CRI's McBrayer Lab: Full 🧵 in comments ⬇️ #relentlessdiscovery science.org/doi/10.1126/scit…

Vorasidenib improves response to subsequent chemoradiation in a genetically engineered mouse model...

A genetic mouse model of IDH-mutant glioma responds to mutant IDH inhibitor (mIDHi) and shows that prior mIDHi treatment improves response to chemoradiation.

science.org
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Science Translational Medicine retweeted
Gladstone Institutes@GladstoneInstAug 6
🚨NEW PUBLICATION 🚨 "Human spinal interneurons repair the injured rat spinal cord through synaptic integration," published in Science Translational Medicine (@ScienceMagazine) science.org/doi/10.1126/scit…

Human spinal interneurons repair the injured rat spinal cord through synaptic integration

Engineered human spinal interneurons rebuild damaged motor circuits after injury, enabling functional recovery through synaptic integration.

science.org
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Science Translational Medicine retweeted
Eric Topol
@EricTopolJul 30
This new review of cancer and neuroscience lays out all current clinical trials and the potential for rebooting neural circuits and change tumor metabolism, blood vessel supply and immune function @ScienceTM science.org/doi/10.1126/scit…
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Science Translational Medicine retweeted
Timothée Bruel@Timothee_BJul 23
1/ 🧵Thrilled to share that our new paper was just published at @ScienceTM @aaas ! 🎉 We show how the complement system boosts the ability of antibodies to neutralize SARS-CoV-2, especially recent variants. 🦠🧫 science.org/doi/10.1126/scit… A thread ⬇️

Complement augments antibody neutralization of SARS-CoV-2 variants

Complement C1q and C3 potentiate neutralization activity of anti-S2 antibodies against SARS-CoV-2 variants via the Fc region.

science.org
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Science Translational Medicine retweeted
Meher Angez@meher_angezJul 23
Excited to see one of my all-time favorite projects finally published in @ScienceTM Medicine! 🎉 I had the opportunity to join this project during my final-year medical school. So grateful to my mentor Dr. Amyn Habib for the opportunity. doi.org/10.1126/scitranslmed…
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Science Translational Medicine retweeted
Alex Puissant Lab@LabPuissantJul 9
Excited to share our latest study with @camille_lobry! Using multiple AML models, we identified splicing dysregulation as a key feature of chemoresistance and relapse in AML. @Institut_IRSL @Leukemia_Inst @ScienceTM tinyurl.com/mt932jky

Splicing-associated network PAK1-CLK1/4-SRRM1 is a vulnerability to overcome chemoresistance in...

Chemoresistance in acute myeloid leukemia depends on an active PAK1-CLK1/4-SRRM1 splicing network that can be targeted to prevent relapse.

science.org
Camille Lobry@camille_lobryJul 8
Thrilled to share the publication of our latest piece of research in @ScienceTM, in collaboration with and led by the amazing @LabPuissantand Camille Vaganay Why does acute myeloid leukemia (AML) so often relapse after chemo works at first? tinyurl.com/mt932jky 🧵

Splicing-associated network PAK1-CLK1/4-SRRM1 is a vulnerability to overcome chemoresistance in...

Chemoresistance in acute myeloid leukemia depends on an active PAK1-CLK1/4-SRRM1 splicing network that can be targeted to prevent relapse.

science.org
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Science Translational Medicine retweeted
Camille Lobry@camille_lobryJul 8
Thrilled to share the publication of our latest piece of research in @ScienceTM, in collaboration with and led by the amazing @LabPuissantand Camille Vaganay Why does acute myeloid leukemia (AML) so often relapse after chemo works at first? tinyurl.com/mt932jky 🧵

Splicing-associated network PAK1-CLK1/4-SRRM1 is a vulnerability to overcome chemoresistance in...

Chemoresistance in acute myeloid leukemia depends on an active PAK1-CLK1/4-SRRM1 splicing network that can be targeted to prevent relapse.

science.org
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Science Translational Medicine retweeted
Prof. Dr. Benhur Lee, MD 🦠🧬🔬
@VirusWhispererJun 12
It takes a Village. Could not have done this without the resources and intellectual camaraderie at @IcahnMountSinai #Microbiology, the clever perseverance of Axel Guzman-Solis, and the generous collaborators from across the country and in the U.K. 1/ What if we could stop a deadly virus not by blocking one doorway, but by locking two at once? New in @ScienceTM: our team developed a two-antibody strategy against Nipah and Hendra viruses, two bat-borne paramyxoviruses with pandemic potential. science.org/eprint/F8QDVNKDX…. #ScienceTranslationalMedicineResearch

A cocktail of human mAbs targeting the henipavirus fusion and receptor binding proteins provides...

A cocktail of antibodies binding the fusion and receptor binding proteins of Nipah and Hendra viruses provides protection and resilience to resistance.

science.org
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Science Translational Medicine retweeted
Faden Lab@FadenLabJun 11
Big day for our lab! New paper using our HPV-DeepSeek assay, an ultrasensitive HPV WGS-based liquid biopsy for MRD detection in HPV+ head & neck cancer, is out today in @ScienceTM 🧵 🔗 science.org/doi/10.1126/scit…

Clinical validation of an HPV whole-genome sequencing assay for MRD detection in patients with HPV+...

An ultrasensitive blood test accurately detects residual disease after surgery and predicts recurrence and survival in HPV+ head and neck cancer.

science.org
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Congrats to the Sunwoo Lab for their recent publication in @ScienceTM! 👏🔬 The @JohnSunwooMD Lab and collaborators, including Dr. Jennifer @FoltzPhd at Wash U, have identified a cytotoxic tissue-resident NK cell subset, characterized by the expression of CD39, CD49a, and CD103.
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Science Translational Medicine retweeted
Dan Western@DanWestern2May 11
I'm very excited to see this work published in @ScienceTM . Proteogenomic studies have grown very rapidly in plasma, with almost every other context being completely ignored along the way. We find that even within closely related contexts (plasma and CSF), (1/3)
Carlos Cruchaga@ccrugomMay 11
Replying to @DanWestern2
@DanWestern2 new @ScienceTM paper (science.org/doi/10.1126/scit…) demonstrates that CSF proteogenomics captures disease‑relevant pathways missed in plasma, uncovering 400+ protein–trait associations across AD, PD, MS, and psychiatric disorders. Less accessible ≠ less important.
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Carlos Cruchaga@ccrugomMay 11
Replying to @DanWestern2
@DanWestern2 new @ScienceTM paper (science.org/doi/10.1126/scit…) demonstrates that CSF proteogenomics captures disease‑relevant pathways missed in plasma, uncovering 400+ protein–trait associations across AD, PD, MS, and psychiatric disorders. Less accessible ≠ less important.
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Science Translational Medicine retweeted
Lucas Kissling@KisslingLucasMay 13
Excited to share our paper in @ScienceTM! Together with @Francesca_Pietr as co-first author, we used in vivo prime editing to correct a pathogenic SCN1A mutation in a GEFS+ mouse model. Huge thanks to all co-authors for their work! doi.org/10.1126/scitranslmed…

Prime editing of a pathogenic Scn1a allele ameliorates seizure phenotypes in a GEFS+ mouse model

Prime editing corrects a pathogenic human SCN1A mutation in mice, reducing seizure frequencies and improving survival in this GEFS+ model.

science.org
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Science Translational Medicine retweeted
David Lagares, PhD, MBA@david_lagaresMay 15
Our latest paper is out @ScienceTM! Natural killer cell immunotherapy reverses lung fibrosis by eliminating senescent fibroblasts | Science Translational Medicine science.org/doi/10.1126/scit… #Immunotherapy #Fibrosis #Aging #Senescence #NKcell
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Science Translational Medicine retweeted
Daphne Zohar
@daphnezoharMar 25
Proud of the work of our Seaport team & collaborators published today in @ScienceTM. This ~13 page peer reviewed paper is the first comprehensive data disclosure of our GlyphAllo™ program from discovery through initial human proof‑of‑concept.
SeaportTx@SeaportTxMar 25
New paper in @ScienceTM features GlyphAllo as first triglyceride-mimetic prodrug to achieve therapeutically relevant drug levels in humans & further validates Glyph platform to effectively enable oral dosing. Paper: tinyurl.com/2mff276w Release: tinyurl.com/5hdenetm
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