@ThomKizzar

PhD Candidate in Biochemistry at UW-Madison - Simcox Lab Member - Interested in lipid transfer and lipid metabolism. UGA Alumnus. Rutter Lab Alumnus. he/they

 Madison, WI
linkedin.com/in/tkizzar/
Joined April 2021
  • Tweets224
  • Following444
  • Followers160
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Hello all! Exciting news! I just accepted my offer of admission to the University of Wisconsin IPiB Program! I’m finally getting my PhD! Big thanks to @RutterLab and my postdoc Jeff who helped me through this insanely long and stressful process. @uwmadisonipib
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Alex Bott@alexjbottJul 7
Happy to share our new preprint from @RutterLab. To understand how genes are controlled, we developed a method we call TRoUT-FISH, using CRISPR + RNA-FISH. We found that glycolytic gene expression is fine-tuned by lineage specifying transcription factors. biorxiv.org/content/10.64898…

Lineage specifying transcription factors determine cell function by direct control of metabolism

Execution of a complex cellular function requires the coherent expression of a set of genes that encode the requisite biochemical program. It is believed that this is typically accomplished by...

biorxiv.org
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Corey N Cunningham@CNFXCJul 7
Excited to share our new preprint from @RutterLab, identifying a melanosomal tyrosine transporter! biorxiv.org/content/10.64898…

SLC16A6 is a tyrosine transporter for the melanosome

Cells enable specialized metabolism by compartmentalizing metabolic pathways into distinct organelles, which requires the membrane transport of metabolites. In melanocytes, the amino acid tyrosine is...

biorxiv.org
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Membrane editing with proximity labeling reveals protein networks and mechanisms regulating lipid homeostasis in the membranes of target organelles nature.com/articles/s41589-0…
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If you’re looking for an Assistant Professor position, in immunology, metabolism, and aging- come join us in Madison! The metabolism community is outstanding and spans the entire campus. jobs.wisc.edu/jobs/immunolog…
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Identification of a common ketohexokinase-dependent link driving alcohol intake and alcohol-associated liver disease in mice go.nature.com/49aV7yv
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MEDNTD@medntdj21 Oct 2025
Microglia-specific regulation of lipid metabolism in Alzheimer’s disease revealed by microglial depletion in 5xFAD Mice nature.com/articles/s41467-0… via @LukensJohnR
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The endoplasmic reticulum donates lipids through a tunnel-like protein to help lysosomes expand. Learn more in a new #SciencePerspective: scim.ag/3HN7mFZ
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I am so incredibly excited to share our latest work, on the exploration of #RNA secondary structure ensembles and discovery of RNA regulatory structural switches in bacteria and human cells, out today in @NatureBiotech: nature.com/articles/s41587-0…. A short tread! (1/n)

Identification of conserved RNA regulatory switches in living cells using RNA secondary structure...

Nature Biotechnology - Transcriptome-scale maps of RNA secondary structure ensembles in living cells detect candidate RNA structural switches.

nature.com
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Officially tenured. Thank you to all the mentors who guided me, and to the trainees who made this possible with your ideas, hard work, and scientific joy.
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Research from the James Ntambi and @JudithSimcox Labs reveals an enzyme’s important role in maintaining a healthy balance of lipids in our bodies. More on their latest research: biochem.wisc.edu/2025/07/02/…

Research in Brief: The What, Why, and How

Research from the Ntambi and Simcox Labs reveals an enzyme’s important role in maintaining a healthy balance of lipids in our bodies.

biochem.wisc.edu
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Eddie Rashan@EdreesRashan22 Jun 2025
As promised, a 🧵 on our recent article now out in @NatureSMB! Co-led with @AbbyBartlett_ @Pagliarini_Lab @JudithSimcox, we find ACAD10/11 are NOT like other acyl-CoA dehydrogenases and instead catabolize atypical lipids called 4-hydroxy acids 🤯#lipidtime doi.org/10.1038/s41594-025-0…

ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism

Nature Structural & Molecular Biology - Rashan, Bartlett and colleagues show that mammalian 4-hydroxy fatty acids are primarily catabolized by ACAD10 and ACAD11 (atypical mitochondrial and...

nature.com
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Calì_Lab@lab_cali23 Jun 2025
🚨 New review out in Nature Reviews Molecular Cell Biology! Expert recommendations for studying organelle contact sites and introduce the concept of organelle contactome 🧬nature.com/articles/s41580-0… Huge thanks to editor Lisa Heinke for the support and guidance! 🙏@NatRevMCB

Key challenges and recommendations for defining organelle membrane contact sites

Nature Reviews Molecular Cell Biology - Membrane contact sites between organelles facilitate the exchange of ions, lipids and metabolites. This Expert Recommendation highlights recent advances in...

nature.com
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Join the #VosshallLab as a postdoctoral scientist! Fully funded position in New York City @RockefellerUniv hhmi.wd1.myworkdayjobs.com/e…
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May was a whirlwind of Simcox lab celebrations. Congratulations to @hunger4science for a successful thesis defense and starting her new position at Pharmaceutical Product Development (PPD, Thermofisher)! Andrea obtained the WISL Award for Communicating PhD Research to the Public
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Wei Lab@wisc@Wei_Lab_WISC19 May 2025
My lab is recruiting a postdoc fellow to characterize new biochemical pathways that control taurine and glucose metabolism. Email me at [email protected] to apply! Please help RT🙏 @longlabstanford @JudithSimcox @UWBiochem
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Thomas Kizzar retweeted
J Cell Science@J_Cell_Sci19 May 2025
In their Cell Science at a Glance article, Antigoni Diokmetzidou & Luca Scorrano @LabScorrano summarise the mitochondrial contacts characterised in mammals, the mechanisms underlying their formation, and their principal functions. journals.biologists.com/jcs/… #JCSMitoSI #OpenAccess
JCS poster ‘Mitochondria–membranous organelle contacts at a glance’ Antigoni Diokmetzidou, Luca Scorrano

ALT JCS poster ‘Mitochondria–membranous organelle contacts at a glance’ Antigoni Diokmetzidou, Luca Scorrano

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Excited to share our latest story on the regulation of lysosomal BMP lipids! Co-led with Raghav Jain, we show that PLA2G15 is a BMP hydrolase that regulates lipid levels under the transcriptional control of TFEB. @JudithSimcox @UWBiochem @HHMINEWS
Cell Metabolism@Cell_Metabolism14 May 2025
New! Online now: Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV dlvr.it/TKmVgH
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Judith Simcox PhD@JudithSimcox15 May 2025
Thrilled to have our story on the regulation of lysosomal lipids out in @Cell_Metabolism! The work was led by two outstanding grad students @_JessDavidson and Raghav Jain probing mechanistic control of energy expenditure @HHMINEWS @UWBiochem
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New! Online now: Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV dlvr.it/TKmVgH
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Thomas Kizzar retweeted
Jay Tan@JayXiaojunTan14 May 2025
Excited to share our latest review "Lysosomal Repair in Health and Disease". We summarized how cells repair lysosomal damage via 4 distinct strategies and discussed the implications for aging, neurodegeneration, cancer, infection, and more. Open access: onlinelibrary.wiley.com/doi/…
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