ALT Dysregulation of nuclear function has been implicated in many human diseases. Thus, identifying and characterizing quality control mechanisms that regulate nuclear structure and function is essential. Herein, we discuss autophagy pathways responsible for the degradation of diverse nuclear cargoes across eukaryotic species and highlight the need for a better understanding of nuclear cargo composition and packaging mechanisms, which remain largely uncharacterized.

ALT In this review, we summarize our knowledge of the mechanisms that ensure the biogenesis of nuclear pore complexes (NPCs), the largest nonpolymeric multiprotein assemblies in eukaryotes. We discuss the challenges related to the synthesis of subunits (i.e., nucleoporins), their association into oligomers and the insertion of NPCs into nuclear envelopes, drawing parallels with the assembly of other multiprotein complexes.