Snapchat: amnewbrough
Pittsburgh, PA
Joined May 2011
- Tweets6.5K
- Following370
- Followers200
- Likes3.6K
Anthony Newbrough retweeted
98% of NIH grants that should have gone out this month, didn't. Despite court orders 'unfreezing' the funds, they are frozen. Biomedical research will grind to a halt. Clinical trials will end. All for no reason: the total impact on the US budget is miniscule
Anthony Newbrough retweeted
GDF15 is turning out to be an extremely important protein (🧵)
It's a stress-responsive cytokine, and the protein that's elevated in the most diseases (by far):
Anthony Newbrough retweeted
Modulating cytokine microenvironment during T cell activation induces protective RSV-specific lung resident memory T cells in early life in mice
nature.com/articles/s44298-0…
@DrTregoning
Anthony Newbrough retweeted
According to a recent paper, the vast majority of academics gain their elite status the old-fashioned way, they were born with rich parents.
Anthony Newbrough retweeted
Like other organelles, the heterogeneity of lysosomes within a single cell has been challenging to capture and study in detail. @Melike_Lak et al. (hubs.la/Q02_PqcV0) tackle this question using DNA-PAINT imaging. Spotlight by Chen & @maxgabgut: hubs.la/Q02_NSx60
Anthony Newbrough retweeted
Study shows that senescent cells literally sugar-coat themselves to avoid recognition and clearance by the immune system. nature.com/articles/s43587-0…
Anthony Newbrough retweeted
Excited to share our new paper in @MolecularCell! We’ve developed TurboCas, a powerful new CRISPR-based proximity labeling tool that lets us pinpoint the proteins regulating gene expression at specific genomic loci. Check out what we discovered: cell.com/molecular-cell/full…
Anthony Newbrough retweeted
#Immunology out now @ScienceMagazine
An unstructured region within MAVS interacts with cellular, rather than viral, RNA. This alters how MAVS interacts with other proteins and influences antiviral responses.
buff.ly/4grnf18
By @nandangokhale, Ram Savan et al.
Anthony Newbrough retweeted
1. Hi #RNA friends, just in time for the holidays I am excited to share the latest pre-print from my group. We solved the structure of a mysterious viral RNA that resists degradation by host nucleases. A short 🧵 & link below – please also check out the full video! #lovevirology
Anthony Newbrough retweeted
Noncoding RNA controls the expression of a gene implicated in drug- and stress-induced behaviors.
Learn more in a new #SciencePerspective: scim.ag/49D7eCD
Anthony Newbrough retweeted
Most people suck at running.
But if you use these 4 running technique tips, I guarantee you won't:
🧵
Anthony Newbrough retweeted
In a surprising paper published in Nature, scientists accomplished what sounds impossible: using genes from a single-celled organism to create mouse stem cells, which eventually developed into a living, breathing mouse.
Anthony Newbrough retweeted
IFN-γ-dependent regulation of intestinal epithelial homeostasis by NKT cells
cell.com/cell-reports/fullte…
@CellReports @BarralLab
Anthony Newbrough retweeted
Biggest medical discoveries of the week (🧵)
1/8
A malaria vaccine - attenuated P. falciparum arrested in the late liver stage - provided 89% protection in a trial of 9 people
This could improve the modest, short-lived protection of current vaccines
nejm.org/doi/full/10.1056/NE…
Anthony Newbrough retweeted
If only we had data on vaccine efficacy
IF ONLY WE HAD THE DATA
#vaccineswork
Anthony Newbrough retweeted
Excited to report that we have discovered a new, endogenous molecular clock in unmodified human cells and tissues. It is ticking away right now in almost every cell in your body.
Specifically, in a new paper on BioRxiv, we show that RNA editing by the near-ubiquitous ADAR1 in unmodified human cells is sufficient to allow us to infer the ages of thousands of species of RNA. This provides a new way to infer past transcriptional dynamics, without any metabolic labeling or genetic engineering, in anything from cultured cells to patient biopsies.
Work by @agreeb66, @JamesBa95200124, @AaronWagen, and many more, and funded by @LNuzhna's Impetus Grants, along with generous support from @ericschmidt and @wenschmidt.
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