Benoit Lehallier (@blehall) header
Benoit Lehallier (@blehall) profile picture

Benoit Lehallier

@blehall

#Nonlinearthinker #Omicsaholic

 California
researchgate.net/profile/Benoit_Lehallier
Joined January 2012
  • Tweets114
  • Following241
  • Followers322
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Photo by Benoit Lehallier (@blehall)Photo by Benoit Lehallier (@blehall)Photo by Benoit Lehallier (@blehall)Photo by Benoit Lehallier (@blehall)Photo by Benoit Lehallier (@blehall)Photo by Benoit Lehallier (@blehall)Photo by Benoit Lehallier (@blehall)Photo by Benoit Lehallier (@blehall)Photo by Benoit Lehallier (@blehall)Photo by Benoit Lehallier (@blehall)
Benoit Lehallier retweeted
Oliver Hahn (@Oliver__Hahn) profile picture
Oliver Hahn
@Oliver__Hahn21 Sep 2022
Excited to share our preprint about the spatiotemporal dynamics of mammalian #brain aging. With our new map generated at @wysscoray lab, we made a step towards understanding when and how the 🧠 ages! 1/9 biorxiv.org/content/10.1101/…
A spatiotemporal map of the aging mouse brain reveals white matter tracts as vulnerable foci

A spatiotemporal map of the aging mouse brain reveals white matter tracts as vulnerable foci

Aging is the key risk factor for loss of cognitive function and neurodegeneration but our knowledge of molecular dynamics across the aging brain is very limited. Here we perform spatiotemporal...

biorxiv.org
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Benoit Lehallier retweeted
Lior Pachter (@lpachter) profile picture
Lior Pachter@lpachter27 Aug 2021
It's time to stop making t-SNE & UMAP plots. In a new preprint w/ Tara Chari we show that while they display some correlation with the underlying high-dimension data, they don't preserve local or global structure & are misleading. They're also arbitrary.🧵biorxiv.org/content/10.1101/…
Image from Lior Pachter (@lpachter)
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Replying to @j_n_justice
@j_n_justice, @blehall and Irene Martinez de Toda will talk about "Involving new blood into #geroscience". Mark your agenda to learn more from these expert leaders at the 2nd @EGeroscience conference. Download our cutting-edge program 👇 bit.ly/3sPzAE7
Image from Geroscience Pre-Clinical and Clinical Trials (@GeroscienceCT)
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Benoit Lehallier retweeted
Mathias Jucker (@MathiasJucker) profile picture
Mathias Jucker@MathiasJucker11 Feb 2021
Blood NfL is associated with mortality in the oldest old. Great collaboration among our lab @TueNeuroCampus @DZNE_en, Tony @wysscoray @StanfordMed, Jonas Mengel-From @SyddanskUni and @MPIAGE. Maybe blood NfL can be used to assess lifestyle interventions #lifestyle and #longevity?
Nature Aging (@NatureAging) profile pictureNature Aging@NatureAging11 Feb 2021
NEW: Age-related increase in plasma neurofilament light chain is associated with mortality in nonagenarians and centenarians and is reduced in mice undergoing dietary restriction. @MathiasJucker @wysscoray nature.com/articles/s43587-0…
A neuronal blood marker is associated with mortality in old age

A neuronal blood marker is associated with mortality in old age

Nature Aging - The authors show that plasma levels of NfL increase with age in humans and are associated with mortality in nonagenarians and centenarians. In mice, a life-extending dietary...

nature.com
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Benoit Lehallier retweeted
Nature Aging (@NatureAging) profile picture
Nature Aging@NatureAging11 Feb 2021
NEW: Age-related increase in plasma neurofilament light chain is associated with mortality in nonagenarians and centenarians and is reduced in mice undergoing dietary restriction. @MathiasJucker @wysscoray nature.com/articles/s43587-0…
A neuronal blood marker is associated with mortality in old age

A neuronal blood marker is associated with mortality in old age

Nature Aging - The authors show that plasma levels of NfL increase with age in humans and are associated with mortality in nonagenarians and centenarians. In mice, a life-extending dietary...

nature.com
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Benoit Lehallier retweeted
Eleanor Sheekey (@EleanorSheekey) profile picture
Eleanor Sheekey@EleanorSheekey1 Dec 2020
What are miRNAs and can they be used as biomarkers for aging? In my latest video I cover @tobias_fehlmann @blehall @wysscoray and others cool latest publication @NatureComms --> youtu.be/9MrOD6UFVwg via @YouTube #miRNA #aging #biomarker #scicomm #academicYouTube
Can miRNAs be used as aging biomarkers?

Can miRNAs be used as aging biomarkers?

What are miRNAs and can they be used as biomarkers for aging?TI...

youtube.com
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Benoit Lehallier retweeted
Nature Medicine (@NatureMedicine) profile picture
Nature Medicine
@NatureMedicine1 Oct 2020
Today is #InternationalDayOfOlderPersons so we look back to a study from @blehall, @wysscoray & colleagues where they characterize the age-related changes in human plasma proteome profiles. This may help identify potential targets for age-related diseases. go.nature.com/34iPZoD
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Today in @nature: Tabula Muris Senis, 1st single-cell aging cell atlas. An #opensource ref dataset of aging-related molecular changes in cells from diff mouse tissues + bio-molecular gold mine for researchers. The work is a Biohub, @Stanford + @UCSF collab go.nature.com/2Wn2vQU
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A Nature paper shows a description of the cell-type composition of all major human organs. The RNA of over 500,000 single cells from Chinese Han donors was sequenced. These data will contribute to the international effort to complete a human cell atlas. go.nature.com/2QKpO4e
Image from Nature Portfolio (@NaturePortfolio)
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Benoit Lehallier retweeted
Mathias Jucker (@MathiasJucker) profile picture
Mathias Jucker@MathiasJucker22 Mar 2020
THE LESSONS OF THE PANDEMIC | Science science.sciencemag.org/conte…
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Aptamer-based proteomic analysis of plasma from healthy individuals aged 18–95 years reveals wave-like patterns of protein expression that are associated with age-related diseases and phenotypic traits | go.nature.com/2t6jdbD |@wysscoray #aging
Image from Nature Medicine (@NatureMedicine)
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Benoit Lehallier retweeted
Alzforum (@alzforum) profile picture
Alzforum@alzforum5 Nov 2019
ApoE Christchurch mutation blocks toxic effects of amyloid, preventing tau tangles, cognitive decline in a woman with a familial #alzheimersdisease mutation. @MassGeneralNews @harvardmed @UdeA @BannerAlzheimer ow.ly/xmRn50x20kx
Image from Alzforum (@alzforum)
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Benoit Lehallier retweeted
Tony Wyss-Coray (@wysscoray) profile picture
Tony Wyss-Coray@wysscoray2 Sep 2019
how about predicting your age based on plasma proteins? or if you are interested in how you favorite protein changes we age, Patrica Moran Losada made an app: twcstanford.shinyapps.io/agi…
Image from Tony Wyss-Coray (@wysscoray)
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Benoit Lehallier retweeted
Tony Wyss-Coray (@wysscoray) profile picture
Tony Wyss-Coray@wysscoray21 Sep 2019
Excited to share Zurine DeMiguel’s study from our lab showing plasma from exercised mice transferred into sedentary ones, reduces brain inflammation and improves cognitive function! The complement and coagulation systems seem to have a key role in this: biorxiv.org/content/10.1101/…
Exercise conditioned plasma dampens inflammation via clusterin and boosts memory

Exercise conditioned plasma dampens inflammation via clusterin and boosts memory

Physical exercise seems universally beneficial to human and animal health, slowing cognitive aging and neurodegeneration. Cognitive benefits are tied to increased plasticity and reduced inflammation...

biorxiv.org
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Common brain disorders are associated with heritable patterns of apparent aging of the brain | Nature Neuroscience nature.com/articles/s41593-0…
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