Biologist & Bioinformatician, Group Leader at the Lander lab @broadinstitute
United States
Joined October 2008
- Tweets412
- Following430
- Followers248
- Likes1.1K
Elisa retweeted
Very excited that our paper is now online! cell.com/cell/fulltext/S0092…
Long thread on our findings on the other app 🦋
Ancient Viral DNA Shapes Early Embryo Development
Researchers at #HelmholtzMunich & @LMU_Muenchen have uncovered the crucial role of transposable elements— ancient viral #DNA remnants— in early embryo development:
👉t1p.de/pb7sc
Key insights:
🌟Ancient viral DNA, once thought to be extinct, is reactivated during the first stages of embryonic development across mammalian species.
🌟Each species expresses distinct transposable elements, which influence cellular plasticity and gene regulation.
💡This discovery opens new possibilities for manipulating cell fate and advancing stem cell research.
💬“Our findings highlight how understanding these elements can revolutionize gene regulation and cellular processes.”
Prof. Maria-Elena Torres-Padilla
@METorresPadilla @epigeneticsHMGU @meoomen @DiegoRTerrones @CellPressNews
#EmbryoDevelopment #Genomics #ViralDNA #StemCells
ALT Ancient Viral DNA Shapes Early Embryo Development
Elisa retweeted
Are you a Master's student with excellent CV in cancer bioinformatics who is about to defend or recently defended? Would like to do a PhD in the Nordics on cancer network modeling? I have an opportunity with tight deadline. Email your CV and motivation:
med.uio.no/ncmm/english/peop…
Elisa retweeted
Published today! We found that cancer cells adapting to drug treatments don't simply switch from a sensitive to resistant state; instead there's a ‘resistance continuum’ of resistant phenotypes with epigenetically reprogrammed states. 🧵⬇️
nature.com/articles/s41586-0… @Gustavo_SFranca
Elisa retweeted
Donnard & Shu et al show how the loss of Fragile X syndrome gene FMRP affects the intricate interactions between different brain cell types
@elisadonnard @garber_manuel @GarberLab @UmassMedbioinfo @ProgMolMed #FragileX #InMice #Genetics #neurons
doi.org/10.1371/journal.pgen…
Elisa retweeted
FINALLY!!!
Single cell transcriptomics reveals dysregulated cellular and molecular networks in a fragile X syndrome model
@elisadonnard @garber_manuel @GarberLab
journals.plos.org/plosgeneti…
Elisa retweeted
@pafgalante: 8,000 fixed retrogene copies in human genome. ~ half show evidence of transcription in 1+ tissue (often brain, testis), at least 1/3 seem translated (ribo-seq). A subset (hundreds) are polymorphic among humans. retrogenes often overlooked in genome biology #DNASRC22
Elisa retweeted
Huge congratulations to graduate student, @IHaoWang1, on the publication of his second paper (and first, first author paper) from the laboratory!
nature.com/articles/s41593-0…
1/n
Elisa retweeted
Excited to share our paper published in @NatureNeuro. With #scRNAseq, machine learning, and #Slideseq, we were able to reconstruct the mouse olfactory glomerular map and explore the potential mechanism of how this map is formed.
@UMassChan
@ProgMolMed
nature.com/articles/s41593-0…
Elisa retweeted
We're in a transition moment in this pandemic
We're coming off highs of the worst surge of infections we've ever had
Cases are high but starting to fall in much of the nation
This moment raises lots of questions
With one big one: What happens next?
Thread
Elisa retweeted
Você já conhece a Revista Brasileira de Bioinformática? Não?! Tem muita coisa legal por lá, incluindo eu e a @elisadonnard falando sobre vias biológicas. Vem conhecer!
bioinfo.com.br/vias-biologic…
Estudante ou pesquisador em bioinfo no Brasil? Olha só o #BrazWebinars com uma seleção excelente de palestrantes! Amanhã tem! bioinfo.icb.ufmg.br/BrazWebi…
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Look up Cambridge and Boston folks! Sky cleared up just in time to see Saturn and Jupiter from the @broadinstitute
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Elisa retweeted
A fantastic write up of AlphaFold2
Interested in AlphaFold 2? Read my piece on how good it actually is, how it works, and what it means for the scientific community and those of us working in computational biology: blopig.com/blog/2020/12/casp…
Elisa retweeted
Congratulations @raya_shu for this excellent work: FMRP links optimal codons to mRNA stability in neurons pnas.org/content/early/2020/…
Elisa retweeted
Olá pessoal - estou procurando oportunidades de trabalho remoto no Brasil. Provavelmente consultorias acadêmicas, workshops de imunologia, vacinas, doenças infecciosas, treinamento científico, ensino, escrita científica, inglês acadêmico e patentes.
#trabalhoremoto
Elisa retweeted
together with Camila Lopes-Ramos from @HarvardBiostats I'll be editing a Special Issue on gene regulatory networks in the journal Cancers. submissions are welcome in 2021: mdpi.com/journal/cancers/spe… via @MDPIOpenAccess
Multiway Enhancer-Promoter Interactions by @pranithakrishna, check it out for some great #generegulation insight cell.com/molecular-cell/full…
Elisa retweeted
Remember March, the endless month? That was the month that the #covid19 #pandemic became real, at least where I work @UMassMedical @broadinstitute. Suddenly we were working from home, and a bit lost. So ... this new paper happened. Here's the story. 1/n pnas.org/content/early/2020/…
Elisa retweeted
only a few more days before the deadline of our PhD position in computational biology at NCMM! you'll join a wonderful research team and an exciting project to develop new methods for network analysis: jobbnorge.no/en/available-jo… #PhDposition @NCMMnews
Elisa retweeted
Pleased to see our collaboration with Dra. B. Malnic (USP) published!
Congrats to @elisadonnard in our lab!
"Depletion of Ric-8B Leads to Reduced mTORC2 Activity" pubmed.ncbi.nlm.nih.gov/3239…
