Associate Professor, Head of the Laboratory of Genetics, Lisbon Medical School, University of Lisbon, Portugal Molecular artist Instagram: paco.enguita
Lisbon, Portugal
Joined March 2012
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CryoEM structure Alpha-Synuclein Type 2B Fibrils (PDB code: 32ED) #scivis #molecularart @dzine_ai @proteinimaging
behance.net/gallery/25761578…
Francisco J. Enguita retweeted
APDB: A Large-Scale Repository of Predicted 2D and 3D Aptamer Structures
pubs.acs.org/doi/10.1021/acs…
#JCIM Vol66 Issue18 #ApplicationNote
Francisco J. Enguita retweeted
how do the 100 blockbuster drugs actually work?
I mapped every one onto its 3D target structure and explained how they work. Small molecules to ADCs.
atlas.dominikscherm.de
Hay que ver lo que hace la IA... Dr. @juansotoivars ... que grande !!!!
youtube.com/watch?v=fIWcvIAK…
CryoEM structure of the Drosophila dmDicer2-LoqsPD-dsRNA in an active-dicing status (PDB code: 7W0E) #scivis #molecularart @dzine_ai @proteinimaging
behance.net/gallery/25729188…
Crystal structure of a fungal flavonoid dehydratase CfvK from Aspergillus candidus (PDB code: 9WVQ) #scivis #molecularart @dzine_ai @proteinimaging
behance.net/gallery/25727512…
Francisco J. Enguita retweeted
If you're interested in how AI is reshaping and accelerating life science, this new issue of @MolecularCell is rich
cell.com/molecular-cell/curr…
single-cell, RNA, protein-protein, genome editing, foundation models , protein design
Like the river feeding into the delta with many tributaries metaphor
CryoEM structure of a nucleosome with an SSB at SHL +5.3 in complex with human PARP2 (PDB code: 9ZXL) #molecularart #scivis @proteinimaging @dzine_ai
behance.net/gallery/25719875…
Francisco J. Enguita retweeted
In Science, researchers present RFdiffusion3, a new generative AI system that designs proteins and nucleic acids atom by atom, which could enable the ability to engineer novel biomolecules with precise, complex functions.
Learn more: scim.ag/4hOQVIF
Crystal structure of Netrin-1 with heparin oligosaccharide ligand (PDB code: 13EW) #scivis #molecularart @dzine_ai @proteinimaging
behance.net/gallery/25713204…
Crystal structure of the mouse FEM1B with small molecule activator (PDB code: 9YHP) #molecularart #scivis @dzine_ai @proteinimaging
behance.net/gallery/25703524…
Crystal structure of wild-type Channelrhodopsin 2 from Chlamydomonas reinhardtii (PDB code: 6EID) @NobelPrize @dzine_ai @proteinimaging #molecularart #scivis
behance.net/gallery/25677089…
Francisco J. Enguita retweeted
Artwork by Francisco Enguita @fenguita, created for a collaborative paper on SCA48 pathogenesis from the Schisler Lab @TheSchislerLab and Brown Lab, is featured on the cover of the Journal of Biological Chemistry @jbiolchem!
Read more: jbc.org/article/S0021-9258(2…
ALT Cover of the Journal of Biological Chemistry
Francisco J. Enguita retweeted
Scripps Research scientists @ColleenMaillie1, Marco Mravic and @WardLab1 describe in @PNASNews an engineered small protein that binds immune receptor TLR4 within cell membranes and reduces signals that can drive inflammation, pointing to a potential drug target for inflammatory diseases. More: ow.ly/svYS50ZTLUf
Francisco J. Enguita retweeted
Cover art by @fenguita. Open-access paper 👉 jbc.org/article/S0021-9258(2…
Francisco J. Enguita retweeted
Paper 2: A cryo-EM structure of Pol λ in the short-range synaptic complex shows how Pol λ and PNKP coordinate end processing, clearing blocked ends and gaps before ligation. Led by Alex Vogt, with the Kunkel, Pedersen, Lees-Miller & Tomkinson labs.
nature.com/articles/s41467-0…
ALT Illustration by Jamie Hefley, created for Lydia Gregg's Molecular & Cellular Visualization course at JHMI: a striking look at how the repair machine holds its tools around a break. Thank you, Jamie!
Francisco J. Enguita retweeted
NHEJ doesn't act on naked DNA. Ku hits a nucleosomal barrier, and DNA-PKcs progressively unwraps nucleosomal DNA to expose the break, clarifying what DNA-PKcs does in chromatin. Led by Weifeng Lu & Alex Vogt, with Susan Lees-Miller.
nature.com/articles/s41467-0…
ALT Illustration of Ku and DNA-PKcs engaging a DNA double-strand break at a nucleosome, showing progressive unwrapping of nucleosomal DNA. Artwork by Elise Brunk, Molecular & Cellular Visualization course (Lydia Gregg), Johns Hopkins Medicine.
Francisco J. Enguita retweeted
"We want to see how far these agent teams of AI scientists can help us to really accelerate drug discovery and development”
go.nature.com/4Aml35h
CryoEM structure of bacterial antiviral defense protein PD-T7-3 in complex with single-stranded DNA and a fragment of RNA (PDB code: 9TRD) #molecularart #scivis @proteinimaging @dzine_ai
behance.net/gallery/25590060…
