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Want to know how to use Ovid to search Medline & Embase, then combine and de-duplicate results? Here's a video: youtube.com/watch?v=gTyOhrtx… #CPD #LiteratureSearching #MedicinesInformation #pharmacy
Jen Smith retweeted
💬 Viewpoint: Routine exclusion of pregnant individuals from RCTs has resulted in gaps in drug safety data, which can lead to unrecognized risks, inappropriate medication avoidance, or delayed guideline recommendations.
bit.ly/4bHq6U7
Jen Smith retweeted
The MHRA is updating product information for statins to reflect the fact that less than 10% of reported muscle-related adverse events are attributable to the medication.
Read the full story on MIMS
buff.ly/mWedNBZ
Jen Smith retweeted
Your regular friendly reminder: These four datasets all have the same mean, median, and variance. Moral of the story: Always visualize your data!
[Link below.]
Jen Smith retweeted
The Shingles vaccine and reduction of dementia: a new natural experiment from Canada replicated 3 others and adds to this week's link to slowing of biological aging.
erictopol.substack.com/p/spo…
Jen Smith retweeted
Restless legs syndrome (RLS), a sleep-related movement disorder, is present in approximately 3% of adults worldwide.
📌 This Review summarizes the pathophysiology, epidemiology, risk factors, diagnosis, treatment, and prognosis of RLS: ja.ma/4jPWlCg
Jen Smith retweeted
Diagnosis made by hallucinatory voices
This is one of those medical cases that sounds unreal, but actually happened.
A middle-aged woman, previously completely healthy, suddenly began hearing voices inside her head. She had no history of mental illness, rarely visited doctors, and lived an ordinary life as a wife and mother.
One winter evening in 1984, while sitting at home reading, she heard a calm, clear voice say:
“Please don’t be afraid. We want to help you.”
The voice claimed that it and another voice had once worked at Great Ormond Street Hospital and wanted her to get medical help. The woman had never been there and had no reason to think about hospitals, which made the experience terrifying.
To convince her they were “real,” the voices told her three specific facts she didn’t know. When she checked, all three turned out to be true.
Instead of feeling reassured, she became convinced she was losing her mind.
Panicked, she went to her doctor and was urgently referred to a psychiatrist.
At the psychiatric clinic, she was diagnosed with a hallucinatory psychosis, meaning she was hearing voices without an external source. She was started on an antipsychotic medication called thioridazine.
Within two weeks, the voices stopped.
Relieved, she went on holiday, believing the problem was over.
But while abroad, still taking her medication, the voices returned.
This time, they were urgent.
They told her something was seriously wrong and that she must return to England immediately. They gave her a specific address and told her to go there.
When she arrived back in London, her husband drove her to the address, just to prove to her that it was “all in her head.”
The address turned out to be the CT scan department of a large London hospital.
The voices told her:
- She had a brain tumour
- Her brainstem was inflamed
- She needed a brain scan immediately
Because the voices had previously given correct information, she believed them, and was extremely distressed.
To reassure her, her psychiatrist requested a CT scan of the brain, clearly stating that there were no physical signs of a brain tumour and that the scan was mainly for reassurance.
The request was initially rejected as unnecessary.
Eventually, the scan was done.
The result was shocking.
It revealed a large tumour in the brain, specifically a left frontal parafalcine meningioma, a type of slow-growing brain tumour arising from the brain’s protective coverings.
Despite its size, she had:
- No headaches
- No weakness
- No speech problems
- No neurological deficits
The tumour was quietly sitting there.
Neurosurgeons discussed whether to wait or operate immediately. Surgery was chosen.
The tumour, measuring about 2.5 × 1.5 inches, was completely removed.
When the woman woke up from anesthesia, she later reported hearing the voices one last time:
“We are pleased to have helped you. Goodbye.”
The voices never returned.
Her antipsychotic medication was stopped immediately. She had no hallucinations, no delusions, and no psychiatric symptoms after surgery.
Why this case is so fascinating:
Doctors have long known that brain tumours can cause psychiatric symptoms, including personality changes, depression, or hallucinations.
But this case was extraordinary because:
- The voices were calm and reassuring
- They gave specific medical instructions
- They directed her to the right hospital
- They disappeared permanently after tumour removal
Some people believed it was something paranormal.
Others suspected fabrication.
Most clinicians agreed on a simpler explanation:
➡️ The tumour likely caused subtle brain changes that expressed themselves as hallucinations, and once the tumour was removed, the symptoms vanished.
The takeaway 👇
This case reminds us that:
- Mental symptoms can sometimes have physical causes
- Brain tumours don’t always cause pain or weakness
- The brain can send distress signals in unexpected ways
Jen Smith retweeted
Amazing stuff - a tweet by @DrLindaDykes regarding toxic healthcare workplace cultures has resulted in a published paper in Qualitative Research in Health. Many congratulations and well done to all involved! sciencedirect.com/science/ar…
Jen Smith retweeted
Three years ago, I posed a question to #MedTwitter asking what are the red flags for organisational toxicity in healthcare. We got nearly 500 replies: a heartbreaking thread oozing with anger and mental anguish.
Well, we made it into a paper.
sciencedirect.com/science/ar…
n/1
Jen Smith retweeted
This video is one of the first times I thought biology was “cool.”
It shows a neutrophil cell chasing a bacterium. Originally recorded in the 1950s by David Rogers at Vanderbilt University, the video gave me a deeper appreciation for life, even at the level of a single cell, because the neutrophil's movements seem so intentful, purposeful, aware.
It wasn’t until recently, though, that I actually tried to demystify the neutrophil’s movements and understand how they happen.
Here's what I learned:
1. The neutrophil's surface has thousands of protein receptors. Molecules secreted by the bacteria collide with these receptors. When that happens, the proteins change shape, slightly, and initiate a signaling cascade.
2. The neutrophil “knows” where to go because of a discrepancy in bound vs. unbound receptors. The side of the cell closest to the microbe will, probabilistically, have more "bound" receptors than the other side (because the molecules secreted by the microbe have a concentration gradient). This is how the neutrophil figures out which way to move.
3. Each bound receptor activates several G proteins located inside the cell membrane. Each G protein, in turn, switches on PI3K enzymes. In this way, the original signal is amplified; a single "activated" receptor might cause ~100 copies of PI3K to get switched on downstream.
4. The PI3K enzymes stick phosphates onto lipids in the cell membrane. The side of the neutrophil facing the bacterium now has more phosphates than the "back" side. Phosphate-binding proteins, such as GEF, accumulate and then recruit Rac, thus activating it. Rac, in turn, acts like a molecular switch, ultimately recruiting Arp2/3. (TL;DR: A bunch of proteins get activated, and the high phosphate concentration at the leading edge is the key signal for all this.)
5. At any given moment, the neutrophil has millions of actin molecules. These are the proteins used to build the cytoskeleton. Half of the actins are already “assembled” into filaments, but the other half are just floating around. Arp2/3 acts as a nucleator, grabbing onto actin and then starting a new cytoskeletal branch. More actin is assembled at the leading edge (where the Arp2/3 has accumulated), where they each push on the cell membrane with ~2 piconewtons of force. Hundreds of actin chains, pushing together, causes the cell to form protrusions.
6. The assembling actin chains push the cell at a speed of ~20 micrometers per minute (the length of about ten E. coli cells placed end-to-end.) As all of this is happening, another signaling cascade, nucleated at the back end of the cell, is dismantling actin filaments and recycling them. All this happens over a span of about 30 seconds.
Much of this process is invisible; what we see, instead, is "just" a cell chasing its prey. But that's the wonderful thing about biology: A singular observation is usually more than enough fodder for a lifetime of work. The well is deep. There is always more to learn.
Jen Smith retweeted
The different smells of spearmint and of caraway seeds are produced by mirror images of the same molecule: carvone
This ability to tell them apart shows that our olfactory receptors can sometimes detect molecular “handedness”
Jen Smith retweeted
Questions about vaccine safety or ingredients may emerge during routine pediatric visits.
Clinicians can address these concerns by explaining vaccine safety monitoring and proactively offering reliable information.
ja.ma/4aOs8RU
Jen Smith retweeted
Prenatal exposure to acid-suppressive medication, including proton pump inhibitors and histamine 2 receptor antagonists, was not associated with increased risk of #ADHD, #ASD, or other neuropsychiatric disorders in children.
ja.ma/4jrCb1t
Jen Smith retweeted
Hyperemesis gravidarum describes a severe form of nausea and vomiting in pregnancy.
A Review summarises current literature on Hyperemesis gravidarum and future directions & research priorities: hubs.li/Q03ZlsTM0
Jen Smith retweeted
There's been minimal progress in advanced pancreatic cancer for decades — that might change this year
Daraxonrasib inhibits RAS, which drives >90% of pancreatic cancers (and was previously thought undruggable!)
Early data look good; the first phase 3 data are expected in June
Retrospective data on early stage (Stage 1A/1B) #PancreaticCancer in the USA & 5-year survival rates
academic.oup.com/jnci/articl…
Jen Smith retweeted
Clinicians can enhance patient understanding by using numerical data instead of verbal probabilities, consistent denominators, absolute risk comparisons, and clear context for unfamiliar data types.
ja.ma/4aKdivK
Jen Smith retweeted
Incredible news in medicine! New treatment for one of the cruellest neurodegenerative conditions - Huntington’s Disease - has resulted in 75% slowing down of disease progression, allowing patients to go back to work and potentially gain decades of life 🙏
bbc.co.uk/news/articles/cevz…
Jen Smith retweeted
The best opening line in any physics textbook: States of Matter by David L. Goodstein ✍️
The thing is, if you read UK Supreme Court judgments, they’re very clear and readable. Yet these are judges at the top of their profession. Being an expert doesn’t mean you have to be dull or opaque.
































