Postdoc @EvanWeberPhD @ChildrensPhila | Fellow @CancerResearch | Fellow @IDEAL_Research | #CART | #SingleCell |#InclusiveTeaching | She/Her 🏳️🌈
Philadelphia, PA
Joined November 2019
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I'm wildly proud to share our FIRST Weber Lab paper, out today in @Nature! I want to share a story about how this whirlwind of a project came together. A 🧵 on teamwork, open science, and how far we can go when we intentionally build a culture of trust in research. 1/
Memory genes are enriched in CAR T cells that persist and control tumors in patients. But which transcription factors drive beneficial memory programs?
We answer this in our lab’s first paper in @Nature led by @alexdoan96 @kpmueller1 @andy_yhchen. 1/
nature.com/articles/s41586-0…
Durable CAR T persistence is among the great unsolved challenges within our field. But what do we actually mean when we say a CAR T cell is "persistent"? @JGrenierMDPhD, @EvanWeberPhD and I attempt to answer this question in our new review @trendscancer. 1/
We start by discussing the current landscape of CAR T persistence in the clinic across both hematological and solid tumor cancers, including a range of CAR T products. 2/ authors.elsevier.com/a/1lo79…
Thrilled to see this work out - congratulations to Dan Pham on a beautiful paper!
Congratulations to Dan Pham for her paper published today! Dan showed that autofluorescence lifetime imaging can monitor single cell metabolism to improve CAR T cell metabolic fitness. @sahakris @UWCarbone @Morgridge_Inst @UWMadEngr
rdcu.be/eGExD
nature.com/articles/s41551-0…
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This is terrifying, heartbreaking, infuriating.
There are days in life that shake you.
I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at @Columbia & academic career... 1/🧵
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Thanks for the shout out, Evan! I'm so honored to work with @CancerResearch, and psyched to get started on these experiments!
Congrats to our talented postdoc @kpmueller1 on receiving this prestigious and competitive @CancerResearch award! Big things to come!
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I'm honored to share that I have been awarded an Irvington Postdoctoral Fellowship from @CancerResearch! This funding will support my ongoing CAR T cell therapy research with @EvanWeberPhD at @ChildrensPhila. 1/
I am deeply grateful for my colleagues and mentors who supported me through many iterations of this proposal. Huge thanks in particular to Suzi McClory, Alice Wang, @CarolineDiorio, @GruppSteve, and @KaiTanLab1, all incredible collaborators who have taught me so much. 2/
Let's goooooooo @EvanWeberPhD!! We are so lucky to have you as our fearless leader!
Early-stage investigators proposed #innovative high-impact research ideas for the @NIHDirector’s New Innovator Award. See the projects the awardees will pursue: commonfund.nih.gov/newinnova… #NIHHighRisk
ALT Card with text reads: 2024 NIH Director's New Innovator Awardees. NIH Common Fund logo next to headshot of awardees.
This is absolutely wild!!
Congrats to my friend and colleague Guosong Hong for his stunning and original discovery, published today in Science, on clearing tissues *in living animals* with a common food dye!
The dye is tartrazine, used in Doritos!
science.org/doi/10.1126/scie…
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CW for police brutality against a queer BIPOC professor. This is how you treat your own, @UWMadison?
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Calling all T cell aficionados, we are hiring!!!
🚨We are hiring a Research Assistant to help us supercharge CAR T cells!
Candidates of all experience levels are encouraged to apply. Some lab experience is required, mouse experience is preferred. 2-year minimum commitment.
Please retweet!
Apply here: chop.wd5.myworkdayjobs.com/C…
CAR T and metabolism folks! Check out this elegant, surprising work from the Mackall lab on enhancing CAR T stemness with a simple culture media substitution. Huge congratulations, @Dori_Na_Krzemie and team!
Our latest work out in Cancer Cell.
#CART #immunometabolism #immunosuppression
Inosine induces stemness features in CAR-T cells and enhances potency sciencedirect.com/science/ar…
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Louder for the people in the back 📢🔥
Dr. Starbird’s vision is incisive, clear, and just plain common sense. Read to the end 👇
So, I want to talk a bit about our recent article on gender equity in science. Some people have commented that the focus should just be on science in rewarding excellence.
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This is bananas ?!
Wow is this cool! Discovery in penguins: Over 10,000 daily naps, each lasting just 4 seconds, accumulate to over 11 hours of restorative sleep. This adaptation to their vigilant lifestyle in Antarctica reveals how sleep benefits can accrue incrementally. science.org/doi/10.1126/scie…
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Psyched for this!!! Come see what we've been up to in the Weber/Mackall labs, presented by the brilliant @alexdoan96!
Beyond excited to present my research on memory reprogramming of CAR T cells at @sitcancer 2023! Thank you to @EvanWeberPhD, @MackallLab, @molecular_elena, @kpmueller1, @andy_yhchen, and many others for collaboration, mentorship, and contributions to this work :)
Let's gooooooo @alexdoan96 💪🧬🔥
CONGRATS to my brilliant mentee @alexdoan96 for receiving a @sitcancer Young Investigator Award! He'll be giving a short talk on memory reprogramming in CAR T cells at the annual meeting in November. Can't wait!
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This is outstanding! I'm so excited to dig into these data, congrats to @sghorashian and team!!
Out today in Nat Med! 🎺
Defining a novel transcriptional signature in long persisting CD19CART in paed ALL patients. doi.org/10.1038/s41591-023-0…
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