Biophysics postdoc at Davide Marenduzzo's lab @EdinburghUni @PhysAstroEd
Joined December 2021
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Super excited to share our latest work looking at mechanisms that contribute to local hexatic and nematic ordering in tissue monolayers!
Intercellular friction and motility drive orientational order in cell monolayers | PNAS pnas.org/doi/10.1073/pnas.23…
Michael Chiang retweeted
M. Chiang, A. Hopkins, B. Loewe, M. Cristina Marchetti, D. Marenduzzo, Intercellular Friction and Motility Drive Orientational Order in Cell Monolayers. arXiv [cond-mat.soft] (2023). arxiv.org/abs/2310.20465
Could everyone in Edinburgh please RT this to maximise the chance of finding a witness of the incident? I suffered a head injury and broke a few teeth because of it and so far there has been no luck with any CCTV footage. The exact timing was more like 8:15am on that day
We are appealing following a crash on Ratcliffe Ter, 8.45am Thurs 26 Jan, involving a blue Vauxhall Corsa and a cyclist. A man aged 27, the cyclist, was taken to ERI for treatment. If you saw what happened or have dash-cam please call us on 101 - Inc 0654 of 26/1/23
ALT graphic with blue background and red box with the words witness appeal
@IanMurrayMP Could you please RT this post to further raise awareness of the incident and increase the likelihood of finding a witness? It happened not far from your office. 🙏
Michael Chiang retweeted
So far, most DNA-loop-extrusion data were taken on naked DNA. But what happens on chromatin in cells where DNA is loaded with many proteins? Will SMC proteins (that are fast but weak motor proteins) get blocked? Or find a way to translocate the roadblock into the extruded loop?
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It's been an awesome week learning and discussing new science at the #EMBOworkshop on Nuclear Structure and Dynamics. Many thanks again to the organisers for giving me the opportunity to speak about our lab's work on HiP-HoP and 3DGene (3dgene.igc.ed.ac.uk)!
What a fantastic experience so far at the Genome Organisation by SMC Complexes conference! It's been great to present my simulation work on 3D gene structure and transcriptional noise and learn about all the exciting new science of SMC proteins. #BioChemEvent
Michael Chiang retweeted
Our work on chromosome micro-manipulation in living cells is out in @ScienceMagazine!
science.org/doi/10.1126/scie…
What if you could put your hand 🫳 inside a nucleus, grab a small portion of a chromosome 👌, and see how it reacts when you pull on it? 🤔
… 🧵 1/n
Michael Chiang retweeted
One new application of the DFCC method for studying nuclear organization. Check out our new story on how RNA Pol II movement during transcription is coordinated over long-range in the context of chromatin dynamics, tandfonline.com/doi/full/10.…
A cool web tool for browsing the simulated gene structures from our paper 'Gene structure heterogeneity drives transcription noise within human chromosomes'.
3dgene.igc.ed.ac.uk
Here is one of my favourite genes - what's yours?
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A #tweetorial of this work: @chromatinlab
Studying the link between gene structure and transcription has been a long-standing problem in chromatin biology. Here, we elucidate trends between these two aspects by simulating the structure of all genes across the human genome. 1/10
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To validate the correlation between noise and loop extrusion, we ran simulations without extrusion. In line with previous work, we saw no notable change in the average transcriptional activity of the genes, but there was a significant decrease in their transcriptional noise. 9/10
