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Agent reasoning
On the scientific rational, the agent worked through the mechanism that drives seizures in this model, then proposed a therapy that increases GABA signalling, the brain's primary inhibitory neurotransmitter, under a promoter that restricts expression to GABAergic neurons.
It decided to put it in lateral entorhinal cortex, reported to be where this kind of seizure originate before it generalises.
It also looked at substantia nigra, a standard target in epilepsy work, and wrote down that its effect depends on which sub-part you hit, it does not hold up across seizure models, and in one study it failed to stop tonic-clonic seizures. Tonic-clonic being what we asked it to reduce.
Coordinates came from three papers, averaged, each one checked to confirm it measured depth from the same reference our rig uses (i.e., surface of the brain). Coords: 3.90 mm behind bregma, 4.00 right, 4.30 down.
It injected 250 nanolitres over five minutes, a total of 5e8 viral genomes. Made decisions on motor speed, wait times... everything.
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On $20 plans, $1 of Sol costs 7x what $1 of Opus does. A task, only 1.3x
Just the API equivalent usage for a subscription isn't enough. You need to show the efficiency of the models as well.
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nigga shut yo bitch ass up. clown
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Fox: Why are you here this morning?
Trump rally attendee: Well, in the late 70s, I was a little too young to go to South America for the Jonestown Massacre. But this is as close as I'll ever get, so that's why I'm here. There's nothing like seeing a cult right up front.
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it's important that you sleep with all of your electronics as close to your head as possible
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Somebody said that Apple is in their Taco Bell era where they're just smashing together random leftover parts from other devices and naming them things like "Phonedito Supreme Crunch" and it's the perfect analogy. Here slap a touch screen on this, charge $4k and call it a Maclupa
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WordPress 7.1.4 is now available. This security release fixes multiple issues, and site owners should update immediately. Update from the WordPress Dashboard or download the release. wp.me/pZhYe-5Ha
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Utah gave Claude Code to 34 developers across 10 state agencies. 80% had a working environment within 30 minutes, 71% reported saving 20+ hours by the end of the four-week pilot.
We're expanding our partnership with @USGSA. Under a new OneGov agreement, we are bringing Claude to federal, state, local, tribal, and territorial governments at 40% off.
anthropic.com/news/expanding…
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negative thinking destroys your brain
being a silly goose and delusionally optimistic is the ultimate longevity hack
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Things are getting serious @typesafeai
Jev now handles logins in Lightpanda's agent. It picks the username field, password field and submit button from the page.
> Jev: 0.53s, 2 calls
> Claude Haiku 5.5 with browser tools: 7.83s, 8 tool calls
github.com/lightpanda-io/bro…
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Introducing 𝙻𝙵𝙼𝟹: our new generation of Liquid Foundation Models. With a new tri-hybrid architecture and new multimodal encoders, the LFM3 family is the ideal model suite for specialized intelligence.
> 6 model instances, across text, audio, vision, and omni modalities, generative and decision models.
> 𝙻𝙵𝙼𝟹-𝟷.𝟽𝙱: text, 256k context window.
> 𝙻𝙵𝙼𝟹-𝚅𝙻-𝟸𝙱: vision-language model with video-input support for spatial understanding
> 𝙻𝙵𝙼𝟹-𝙰𝚞𝚍𝚒𝚘-𝟸𝙱: tool calls, voice chat, reasoning in 18 languages.
> 𝙻𝙵𝙼𝟹-𝙾𝚖𝚗𝚒-𝟸𝙱: an omni model combines vision, audio, and language.
> 𝚍𝟷-𝟸𝙱 and 𝚍𝟷-𝙾𝚖𝚗𝚒-𝟸𝙱: decision models with typed outputs and calibrated probabilities in a single pass. Omni adds audio input.
> fine-tune on 1 GPU.
> a new tri-hybrid architecture
> architecture optimized for 14 processor classes across GPUs, CPUs, and NPUs.
> 𝙻𝙵𝙼𝟹-𝚅𝙻-𝟸𝙱 is a beast. It performs competitively with Gemma 4 12B (6x larger), and Gemini 3.5 Flash Lite, and GPT-5.6 Luna, with 1.9B parameters.
> 𝙻𝙵𝙼𝟹-𝟷.𝟽𝙱 is #1 on the Pareto frontier of device intelligence 𝚙𝚒𝚙𝚎𝚝𝚝𝚎.𝚕𝚒𝚚𝚞𝚒𝚍.𝚊𝚒
Every modality for specialized intelligence. Pick the one that fits your use case, customize it, and run it on-device.
1/ 🧵
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The coding interview is dead, at least for my team at Anthropic. I've seen enough to know that it no longer provides signal. I removed it from loops this month.
I have a spicy, optimistic take - I think there's an opportunity for junior engineers: felixrieseberg.com/hunger-be…
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Discord is about to put your public messages on Google
Discord will start making messages from Discoverable public servers searchable on Google and other search engines from mid-December.
The feature is ON by default in most regions, but you can opt out:
User Settings → Data & Privacy → turn off “Show my message content from Discoverable channels on web pages.”
In the EU, UK, Canada, Brazil, Australia and South Korea, it will be OFF by default.
Private servers, DMs and group DMs are not included. Usernames and avatars won’t appear alongside indexed messages.
