Immunologist working on autoimmunity, memory and T cells in cancer
Joined February 2020
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Check out the N&V in @NatImmunol by Inaki Sanz about @elsner_rebecca @ShlomchikLab's recent paper on how B cell intrinsic IL-12 promotes EF and suppresses GC responses via an autocrine positive feedback loop with IFNg. nature.com/articles/s41590-0…
Mark Shlomchik retweeted
I'm thrilled that the very first paper from my lab, also my first senior author paper, is now online @CellReports.
cell.com/cell-reports/fullte…
Mark Shlomchik retweeted
2- which model are you using? what is triggering lupus in it?
Is it known WHY one of the TLRs is protective and the other pathologic? Only the intracellular signaling? Different recognition of different nucleotides (from… self? Infections?) may have a role?
THANSKS!!!
Mark Shlomchik retweeted
Check out the clip below to learn from the career advice given by last Wednesdays #globalimmuno speaker speaker Dr. Mark Shlomchik
Full talk is available in “Global Immunotalks” YouTube Channel youtu.be/zm7RVMOLk_E
Mark Shlomchik retweeted
ASCI member @mshlomchik @shlomchiklab @PittTweet in @JCI_insight: Severe lupus in TLR9- deficient mice requires B cell-specific TLR7: buff.ly/3YX65jS
#Immunology
Mark Shlomchik retweeted
@ShlomchikLab @MShlomchik Happy 30th anniversary! Thanks for hosting a phenomenal symposium. No better way to celebrate!
Mark Shlomchik retweeted
Is IL-21R signaling in GC B cells different from naive B cells? How do different combinations of BCR, IL-21R and CD40 signals impact GC B cell fate choice? Differences between IgG and IgM GC B cells?
For answers, check out our paper in Science Immunology:
science.org/doi/10.1126/scii…
Mark Shlomchik retweeted
Good things come in pairs! ✌️
Check out these two new @SciImmunology articles investigating differentiation and signaling of germinal center #Bcells.
1️⃣ bit.ly/3xxbwsX by @luoweicool, @ShlomchikLab & co.
2️⃣ bit.ly/3xyQzh6 by @YUmmunology & co.
Mark Shlomchik retweeted
Age-associated B cells are heterogeneous and dynamic drivers of autoimmunity in mice, say Kevin Nickerson @KMNickerson, Mark Shlomchik @mshlomchik @Shlomchiklab @PittTweet & colleagues. bit.ly/3ZgTxTw
See video summary by Nickerson: youtu.be/YbRb282V6ZI
#Autoimmunity
Mark Shlomchik retweeted
In our latest @JExpMed study, we characterized age-associated B cells (ABCs) in a model of lupus. We found unexpected heterogeneity among ABC subpopulations, identified precursor-product relationships, and showed that reducing ABCs improved renal disease. A 🧵! (1/12)
The Shlomchik lab, in a group effort led by Dr. Claire Leibler, former postdoctoral fellow, has published their work in Nature Immunology on how TLR9 has both negative and positive regulatory functions in lupus. The links are here: pubmed.ncbi.nlm.nih.gov/3615…
nature.com/articles/s41590-0…
Check out my Immunology Podcast, just posted by @ImmunoPodcast . Enjoyed chatting with Brenda and Jason about how basic research can lead to applications. I talk about starting the personalized cancer immunotherapy company @BlueSphereBio with my brother Warren. @ShlomchikLab
Mark Shlomchik retweeted
Germinal Center and Extrafollicular B Cell Responses in Vaccination, Immunity, and Autoimmunity cell.com/immunity/fulltext/S…
I thought this was particularly telling. Let's hope he's the only face ever that has to occupy this ignominious intersection
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Mark Shlomchik retweeted
Hot off the press: Weisel et al (2020) "Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis." Congrats to Flo and the team.
nature.com/articles/s41590-0…