@munchie37
 Auburn
paulcobine.wixsite.com/cobinelab
Joined December 2010
  • Tweets316
  • Following696
  • Followers294
4Media
Paul Cobine retweeted
Cell@CellCellPressSep 14
Now online! Copper ion-induced MYH9 polymerization executes cuproptosis dlvr.it/TVTSKL

Copper ion-induced MYH9 polymerization executes cuproptosis

Copper binding drives MYH9 polymerization, triggering cytoskeletal collapse and cuproptosis. HThPA releases intracellular copper through glutathione depletion, exposing a therapeutic vulnerability in...

cell.com
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Excited to share our new @biorxivpreprint from the @BradyLab led by Santanu Ghosh. “Mitochondrial copper stabilizes lipoylated TCA cycle proteins to sustain metabolism and proliferation” biorxiv.org/content/10.64898…
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Paul Cobine retweeted
ASBMB@ASBMB10 May 2025
"Cancer cells don’t quickly adapt or rewire this copper dependency, which creates a therapeutic window. By introducing a copper chelator, we can dampen the MAPK signaling that tumors rely on for growth." —@bradylabupenn, @jbiolchem associate editor ow.ly/hVCN50VQpfS

Meet Donita Brady

Donita Brady is an associate professor of cancer biology and an associate editor of the Journal of Biological Chemistry, who studies metalloallostery in cancer.

asbmb.org
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A study published today in @AppEnvMicro shows that calcium plays a significant role in enhancing the resistance of potato plants to bacterial wilt: asm.social/1Qg
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Our new preprint is here! A great collaboration work with Paul Cobine @munchie37 ! @marcel_m86, Gabi Mediavilla y Xinju !!
bioRxiv@biorxivpreprint13 Apr 2024
Copper trafficking in Trypanosoma cruzi: the transcriptional response of candidates to balance toxicity and recruitment biorxiv.org/cgi/content/shor… #bioRxiv
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OUT NOW!!! My latest paper with the Kornfeld lab, Lysosome-related organelles contain an expansion compartment that mediates delivery of zinc transporters to promote homeostasis. A 🧵 pnas.org/doi/10.1073/pnas.23…
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COQ4 is required for the oxidative decarboxylation of the C1 carbon of coenzyme Q in eukaryotic cells cell.com/molecular-cell/full…

COQ4 is required for the oxidative decarboxylation of the C1 carbon of coenzyme Q in eukaryotic...

Coenzyme Q, a redox lipid crucial for cellular bioenergetics and homeostasis, is synthesized by a multi-step pathway. Here, Pelosi et al. unveil the missing enzyme of the eukaryotic pathway by...

cell.com
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Paul Cobine retweeted
FrezzaLab@FrezzaLab29 Dec 2023
Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis: Molecular Cell cell.com/molecular-cell/full…
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The ARC is pleased to appoint Professor Alastair McEwan as Executive Director for Biological Sciences and Biotechnology. Professor McEwan brings a wealth of knowledge and real-world experience to promote Australian research excellence. Read more: ow.ly/vhin50Q5i9A
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Please RT and tell your biochemistry/molecular biology/chemical biology/neurobiology/neurochemistry postdocs to apply! We will also welcome applications from established investigators who are looking for a new opportunity. ⤵️⤵️⤵️
USC Chemistry & Biochemistry@UofSC_Chem26 Sep 2023
We are hiring! Come join our award-winning, collegial department located in the heart of SC. We are seeking applicants for tenure-track positions in both biochemistry and polymer chemistry. @Chemjobber #facultychemjobs uscjobs.sc.edu/postings/1539…
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Paul Cobine retweeted
FrezzaLab@FrezzaLab21 Sep 2023
... and here the paper, a milestone for the field! Manipulating mitochondrial electron flow enhances tumor immunogenicity | Science science.org/doi/10.1126/scie…

Manipulating mitochondrial electron flow enhances tumor immunogenicity

Modulating mitochondrial electron flow improves tumor immune response.

science.org
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Department of Biological Sciences at @AuburnU is hiring an Assistant Professor specializing in Physiology. Link for more information and to apply: auemployment.com/postings/40…
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Paul Cobine retweeted
FrezzaLab@FrezzaLab22 Jul 2023
"Lactate modulates iron metabolism by binding soluble adenylyl cyclase" cell.com/cell-metabolism/ful…

Lactate modulates iron metabolism by binding soluble adenylyl cyclase

Liu et al. report that intracellular LA imported by MCT1 binds to sAC to increase cAMP level and thereafter promotes PKA-Smad1/5/8 signaling to induce hepatic hepcidin expression, thereby modulating...

cell.com
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Check out our @nchembio News & Views w/@christhechang highlighting a recent @Nature study describing how copper ions drive inflammation via a mitochondrial signaling pathway that regulates epigenetic states of immune cells. nature.com/articles/s41589-0…
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Paul Cobine retweeted
Palmer Lab@AmyPalmerLab1 Jul 2023
The title says it all: Human cells experience a pulse of zinc in early G1 (doi.org/10.1016/j.celrep.202…). Using fluorescent reporters, long term imaging, and computational image analysis, @AnanyaRakshit4 and @samholtzen quantify free zinc in naturally cycling cells.
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Pathogenic forms of the ANT1 protein lead to harmful consequences in yeast and mice by clogging the channels that allow mitochondria to import proteins. elifesciences.org/digests/84…
4 mice of different colours

ALT 4 mice of different colours

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A new Science study in Trinidadian guppies shows that females that mate with males with uncommon traits have “sexy” sons who go on to sire higher numbers of offspring per month than their counterparts. Learn more: scim.ag/2pX
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Thanks to a collaboration between @BiochemMetal @unistra and the group of Prof. Silvia Morante @unitorvergata, we characterized a key redox intermediate of the Copper-Amyloidβ complex by XAS at @esrfsynchrotron. Now Open Access in @angew_chem onlinelibrary.wiley.com/doi/…

Chasing the Elusive “In‐Between” State of the Copper‐Amyloid β Complex by X‐ray Absorption through...

The combination of X-ray induced photoreduction and thermal relaxation unravels the structure of an intermediate of the CuII/CuI Aβ1–16 redox cycling. The X-ray beam promotes CuII reduction to CuI...

onlinelibrary.wiley.com
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Congratulations Vishal! It was a pleasure working with your group. FDX1-dependent and independent mechanisms of elesclomol-mediated intracellular copper delivery | Proceedings of the National Academy of Sciences pnas.org/doi/10.1073/pnas.22…

FDX1-dependent and independent mechanisms of elesclomol-mediated intracellular copper delivery |...

Recent studies have uncovered the therapeutic potential of elesclomol (ES), a copper-ionophore, for copper deficiency disorders. However, we curren...

pnas.org
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