Andrew Wiles worked on Fermat's Last Theorem alone in his attic for 7 years and told nobody except his wife. The problem was 358 years old. Fermat scribbled in a margin in 1637 that he had a proof and no room to write it, and every mathematician since had failed. Wiles saw the statement in a library book at 10 years old. He never let it go. He was a Princeton professor when he started in 1986. He stopped publishing new work and released old results in pieces to hide the silence. He announced it in Cambridge in June 1993, over 3 lectures, revealing the target only at the end. Newspapers ran it worldwide. Then a referee found a gap. One step in the proof did not hold, and the error was fundamental. He spent 14 months trying to close it in public view, with the whole field watching. He was ready to quit. The fix arrived in September 1994. He has said he stared at it in disbelief for 20 minutes. The BBC filmed him describing that moment. He gets a few words out, then turns away from the camera in tears. He kept the greatest result of the century secret so nobody could take it.

GPT-Rosalind surfaced a new lead for drug discovery: could restoring cholesterol transport protect neurons from degeneration? DCTN1 is a gene linked to Perry syndrome, a rare neurodegenerative disorder. In mouse-brain data, disrupting it increased expression of genes involved in making cholesterol. GPT-Rosalind suggested a possible explanation: cholesterol may not be reaching where neurons need it. That gives scientists a specific mechanism to test and, if confirmed, a direction for developing new treatments for neurodegenerative disorders. With @perturbai_tx and @scrippsresearch, a team of thousands of GPT-Rosalind agents worked in parallel, connecting gene-expression results from millions of mouse brain cells with scientific literature in just 32 minutes. We’re now expanding this collaboration to identify new drug targets. openai.com/index/scaling-ai-…

Unitree back in the robot fighting game

OpenAI models helped researchers—operating as part of our Patch the Planet initiative—discover critical security flaws in PHP, an open-source programming language used to run an estimated 70% of websites. Over the past two months, we led a coalition of maintainers, researchers, and security providers to prepare fixes and protections ahead of disclosure. This duration was necessary because the fix was quite intricate and required a major change to the PHP engine. Every site using PHP can now safely upgrade their version to stay secure, in addition to applying mitigations from various security vendors. Due to the severity of these flaws and PHP’s widespread use, we consider this bug to be one of the most impactful vulnerabilities in recent memory. It also marks a new phase, where AI can find security bugs with internet-scale impact. This is an example of the Defender’s Window in action: to our knowledge, frontier AI was able to find this vulnerability ahead of attackers, giving defenders time to prepare. openai.com/index/coordinated…

Des véhicules de police sont prises pour cible par la foule dans le secteur République à Paris. #Paris #17octobre

⚠️🔴 À REGARDER JUSQU'À LA FIN JE NE PEUX PAS DÉCRIRE CE QUE JE VIENS DE VIVRE À MARSEILLE. #17octobre

Elon is the motherfuckin’ GOAT. He takes things most people only dream about and makes them fucking real. That’s just the damn truth. I went to see a car unveil and watched a Roadster drive upside down, launch with thrusters, and do flips and rolls through the air. How do you watch that and not feel like a kid again?! Tonight was the best product unveil I’ve ever seen, literally the best unveil of ANY product. Hands down. Huge respect to Elon and everyone at Tesla and SpaceX who put in the work to make this happen. You absolutely fucking delivered. I had my @Grok Bot pull the official stream, find the best moments, and cut this video together by the end of the night. I had to watch it again to understand how unbelievable today was.