Structural Biologist. Prof. at INRS-U. of Quebec (Montreal, QC). I study enzymes and I have 2 lovely daughters. Tweets are my own. He/Him/Il. @nicdou@mas.to
Montréal, Québec
Joined February 2009
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New in #ProteinScience! @ProteinSociety🥳 We explored allosteric pathways in galectin-7, a key protein in high-fatality cancers. We identified dynamic nodes for functional modulation in #glycobiology.
Read: doi.org/10.1002/pro.70502
@GlycoNet @NSERC_CRSNG @FRQS1 @CanLightSource
Entrevue à Point du Jour de @RadioCanada sur notre recherche à l’@inrsciences. Étude des ribonucléases, leur structure 3D et rôles biologiques.🔬👩🏻🔬 Grâce au @CanLightSource et au financement de @NSERC_CRSNG, @ProteoQuebec et @FRQS1. 🧬🧫 tinyurl.com/mvc9nxhp
#enzymes #science
Thank you to our colleagues from @UABBarcelona and @TrendsBiochem for this wonderful Spotlight article about our work published in @jbiolchem! 🧬🧑🏼🔬 #ASR #proteinengineering #biochemistry @inrsciences @Pratul_Agarwal @NSERC_CRSNG @FRQS1
Available online - the Spotlight "Ancestral #ribonucleases back in motion for evolutionary-dynamics guided #proteindesign" from Ester Boix and Jiarui Li @UABBarcelona.
#moleculardynamics #ancestralsequencereconstruction #proteinevolution
Read it here 👉 authors.elsevier.com/a/1jGPt…
Nicolas Doucet retweeted
Available online - the Spotlight "Ancestral #ribonucleases back in motion for evolutionary-dynamics guided #proteindesign" from Ester Boix and Jiarui Li @UABBarcelona.
#moleculardynamics #ancestralsequencereconstruction #proteinevolution
Read it here 👉 authors.elsevier.com/a/1jGPt…
Thank you, @CanLightSource, for highlighting our article published in @jbiolchem! 🧬🧑🏼🔬 Researchers from @inrsciences are using the CLS to study how #enzymes can be modified to our advantage. #proteinengineering #biochemistry #ASR @Pratul_Agarwal
Researchers from @inrsciences are using the CLS to study how #enzymes found in all forms of life can be modified to work to our advantage - for everything from better cancer treatments to more efficient, enviro-friendly industrial catalysts. bit.ly/3VviuKu #health #dna
Merci @CanLightSource pour la mise en valeur de notre article publié chez @jbiolchem ! 🧬🧑🏼🔬 « Des chercheurs de l'@inrsciences utilisent le CLS pour étudier comment les #enzymes peuvent être modifiées à notre avantage. » #proteinengineering #biochemistry #ASR @Pratul_Agarwal
Researchers from @inrsciences are using the CLS to study how #enzymes found in all forms of life can be modified to work to our advantage - for everything from better cancer treatments to more efficient, enviro-friendly industrial catalysts. bit.ly/3VviuKu #health #dna
Heureux et fier de participer à cette collection dédiée à l’ingénierie enzymatique éditée par @Chica_lab ! 🧬🧫🧑🏼🔬 Notre contribution est généreusement supportée par le @CRSNG_NSERC et le @FRQS1. #proteine #enzyme @inrsciences
Check out our latest special collection on #enzyme engineering! With contributions from @GreenGroupMIB, @IvanaDrienovska, @DavidKwanPhD, @ZhongyueY, Joelle Pelletier, @nicdou, Vincent Eijsink, Steve Mayo and others.
Free to read and download until September 30, 2023!
Nicolas Doucet retweeted
I’ve learned from a decade on this app to not accept the superficial way things are presented here, especially when someone’s words are being used against them. And so I watched the whole session for context. And I’m glad I did. Because in context it’s way worse.
This quoted post is unavailable.
Nicolas Doucet retweeted
Bravo à l'équipe de @nicdou @inrsciences pour leur avancée dans la dynamique moléculaire chez les #enzymes! Une recherche appuyée par le @CRSNG_NSERC, les @NIH, la Fondation Armand-Frappier & le @FRQS1.
#communautéFRQ
@jrjulierobert @CongresAF
bit.ly/3M71Z3G
Nicolas Doucet retweeted
Team headed by N. Doucet @inrsciences & @Pratul_Agarwal reveals functional and evolutionary divergent features that govern conformational exchange within structurally homologous eosinophil ribonucleases @nicdou @tmhmpl @NSERC_CRSNG @FRQS1
doi.org/10.1016/j.str.2022.1…
#Budget2023 unfortunately means that graduate students will continue to live below the poverty line in Canada! 🇨🇦 Sad. 🤦🏼♂️😢 @cafreeland @justintrudeau #SupportOurScience @SupportOurSci @FP_Champagne @CIHR_IRSC @NSERC_CRSNG #ISupportGradStudents #ISupportPostdocs @inrsciences
Nicolas Doucet retweeted
The 8th annual meeting of the Biophysical Society of Canada @BiophysCanada will be held at @UCalgary from May 23rd to 26th.
Abstracts are due on April 15th.
For information on a list of speakers and other details, visit
event.fourwaves.com/bsc2023/…
Please RT and spread info. – at Calgary, Alberta
Prolongation de la période de mise en candidature du poste d’agent.e de #recherche en #biophysique à @inrsciences. Soumettez votre candidature d’ici au 6 mars 2023 et/ou partagez parmi vos contacts et vos réseaux ! 🧪🧬👩🏽🔬 inrs.ca/offres-d-emploi/agen…
J’ai écrit ça sur le coup de l’émotion,💔 mais c’est un peu le ras-le-bol face à la démission de notre @GouvQc. @LeFredSavard, merci d’être l’un des seuls qui en parle encore. Désormais, la tristesse en ressort bien davantage que la colère.😢 Merci @LeDevoir d’avoir publié.🌹
Au-delà des larmes bit.ly/3JVk3gJ
Nicolas Doucet retweeted
Bunny eating strawberries.. 😋 xitter.cf/buitengebieden/status/…
Nicolas Doucet retweeted
Quand même le Journal de Montréal écrit un article sur le sous financement de la recherche... c'est qu'il y a vraiment un problème. @FP_Champagne @JustinTrudeau : il est temps de réinvestir dans le financement de la recherche au Canada.
journaldemontreal.com/2023/0…
We believe the next frontier in #enzyme engineering is to exploit their #dynamics. Always a pleasure to work with #JoellePelletier and @claudele_ from @UMontreal! 👩🏻🔬🧬👩🏽🔬🧪 Thanks to our funding partners and RIP #DanTawfik.😢 @CRSNG_NSERC @FRQS1 @inrsciences @SciChefQC @SciChefCan
With @nicdou and #JoellePelletier, we recently reviewed the state of knowledge in ‘dynamic engineering’, i.e. the rational modification of #protein dynamics to alter #enzyme function! doi.org/10.1093/protein/gzac…
#ProteinEngineering
@ProtEngDesSel @NSERC_CRSNG @inrsciences @UMontreal
Merci @claudele_ et @Bio_Lorea pour cette belle collaboration avec le groupe de #JoellePelletier ! À la mémoire de Liz Howell (R.I.P.). 😥 @UTKnoxville Bonne chance avec la suite ! 🧬👩🏻🔬🧫🧪👍🏼 @inrsciences @UMontreal @CRSNG_NSERC @FRQS1
Our first effort to decipher the origin of DfrB enzymes – which have no characterized homologues known to date – is out: doi.org/10.1098/rstb.2022.00…!
This family, identified because it provides high #AntibioticResistance, has many peculiarities 👀🧵 (1/8)
#DfrBNews #ProteinEvolution